A5082205914- Renal cell carcinoma treatment
- MRI in cancer diagnosis
- Childhood Cancer Survivors' Quality of Life
- Radiomics and Machine Learning in Medical Imaging
- Renal and related cancers
- Advanced X-ray and CT Imaging
- Advanced MRI Techniques and Applications
- Atomic and Subatomic Physics Research
- Cardiac Imaging and Diagnostics
- Medical Imaging Techniques and Applications
- Radiation Dose and Imaging
- Histiocytic Disorders and Treatments
- Bladder and Urothelial Cancer Treatments
- Epigenetics and DNA Methylation
- Cancer Genomics and Diagnostics
- Vasculitis and related conditions
- Eosinophilic Disorders and Syndromes
- Urinary and Genital Oncology Studies
- COVID-19 Clinical Research Studies
- Glioma Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Neuroblastoma Research and Treatments
- COVID-19 diagnosis using AI
- Genetic and Kidney Cyst Diseases
- Neuroendocrine Tumor Research Advances
National Institutes of Health Clinical Center
2016-2025
National Institutes of Health
2015-2024
Georgetown University
2024
University of Maryland, Baltimore
2024
University of Maryland, College Park
2024
MedStar Georgetown University Hospital
2024
National Cancer Institute
2018-2024
Center for Cancer Research
2020-2024
Office of the Director
2024
Leidos (United States)
2024
Chest CT is emerging as a valuable diagnostic tool for clinical management of COVID-19 associated lung disease. Artificial intelligence (AI) has the potential to aid in rapid evaluation scans differentiation findings from other entities. Here we show that series deep learning algorithms, trained diverse multinational cohort 1280 patients localize parietal pleura/lung parenchyma followed by classification pneumonia, can achieve up 90.8% accuracy, with 84% sensitivity and 93% specificity,...
Background Commercial low-field-strength MRI systems are generally not equipped with state-of-the-art hardware, and suitable for demanding imaging techniques. An system was developed that combines low field strength (0.55 T) high-performance technology. Purpose To evaluate applications of a system, specifically MRI-guided cardiovascular catheterizations metallic devices, diagnostic in high-susceptibility regions, efficient image acquisition strategies. Materials Methods A commercial 1.5-T...
Objective To assess the clinical value of 18 F‐fluorodeoxyglucose ( FDG ) positron emission tomography PET in a prospective cohort patients with large vessel vasculitis LVV and comparator subjects. Methods Patients Takayasu arteritis giant cell were studied, along group consisting hyperlipidemia, diseases that mimic , healthy controls. Participants underwent evaluation ‐ imaging, serial imaging at 6‐month intervals. We calculated sensitivity specificity interpretation for distinguishing...
Erdheim-Chester Disease (ECD) is a rare, potentially fatal, multi-organ myeloid neoplasm occurring mainly in adults. The diagnosis established by clinical, radiologic, and histologic findings; ECD tumors contain foamy macrophages that are CD68+, CD163+, CD1a-, frequently S100-. purpose of this report to describe the clinical molecular variability ECD. Sixty consecutive patients (45 males, 15 females) were prospectively evaluated at NIH Clinical Center between 2011 2015. Comprehensive imaging...
Purpose To evaluate the performance of a prototype photon-counting detector (PCD) computed tomography (CT) system for abdominal CT in humans and to compare results with conventional energy-integrating (EID). Materials Methods The study was HIPAA-compliant institutional review board–approved informed consent. Fifteen asymptomatic volunteers (seven men; mean age, 58.2 years ± 9.8 [standard deviation]) were prospectively enrolled between September 2 November 13, 2015. Radiation dose–matched...
Purpose To investigate whether photon-counting detector (PCD) technology can improve dose-reduced chest computed tomography (CT) image quality compared with that attained conventional energy-integrating (EID) in vivo. Materials and Methods This was a HIPAA-compliant institutional review board-approved study, informed consent from patients. Dose-reduced spiral unenhanced lung EID PCD CT examinations were performed 30 asymptomatic volunteers accordance manufacturer-recommended guidelines for...
Objectives To assess agreement between interpretation of magnetic resonance angiography (MRA) and 18 F-fluorodeoxyglucose positron emission tomography (PET) for disease extent activity in large-vessel vasculitis (LVV) determine associations imaging clinical assessments. Methods Patients with giant cell arteritis (GCA), Takayasu’s (TAK) comparators were recruited into a prospective, observational cohort. Imaging assessments performed concurrently, blinded to each other. Agreement was assessed...
Kidney tumors lacking fumarate hydratase become aggressive due to a metabolic shift arising from altered mitochondrial DNA.
5004 Background: HLRCC is a familial cancer syndrome associated with type 2 papillary RCC (pRCC) variant. caused by germline mutations in the gene for Krebs cycle enzyme fumarate hydratase (FH). FH inactivation results VHL-independent upregulation of hypoxia inducible factor, reliance on aerobic glycolysis, and activation NRF2 pathway, features also shared some sporadic pRCC tumors. We hypothesized that metabolic alterations underlying these tumors would be susceptible to targeted therapy...
Abstract Objective Heart failure is a major contributor to cardiovascular morbidity and mortality in patients with rheumatoid arthritis (RA), but little known about myocardial structure function this population. This study was undertaken assess the factors associated progression heart RA. Methods With use of cardiac magnetic resonance imaging, measures were assessed men women RA enrolled Evaluation Subclinical Cardiovascular Disease Predictors Events Rheumatoid Arthritis study, cohort...
To compare the performance of energy-integrating detector (EID) CT, photon-counting CT (PCCT), and high-resolution PCCT (HR-PCCT) for visualization coronary plaques reduction stent artifacts in a phantom model.An investigational scanner with EID subsystems was used to image artery containing cylindrical probes simulating different plaque compositions. The imaged without stents using both subsystems. Images were reconstructed clinical cardiac kernel an additional HR-PCCT kernel. Regions...
Published series of growth rates renal tumors on active surveillance largely consist without pathologic or genetic data. Growth kinetics genetically defined are not well known. Here, we evaluate the and their association with patient clinical characteristics.
The optic nerve is part of the central nervous system, and a rise in intracranial pressure (ICP) can directly affect perioptic space, leading to an increase diameter. Transorbital sonography safe easy-to-perform method measure diameter for rapid diagnosis increased ICP.The was measured 3 individual occasions by transorbital transverse view, mm posterior papilla both eyes, mean calculated. Two groups were examined: control group children with normal ICP ophthalmologic examination results case...
To determine the correlation function between steady-state free precession (SSFP) and fast gradient echo (FGRE) cine MRI pulse sequences for measuring myocardial mass volumes.Cardiac examinations were acquired in 50 individuals (female: 35, male: 15, mean age 64.1 +/- 9.1 years, range 48-83) using SSFP FGRE cardiac sequences.The (standard deviation [SD]) left ventricular end diastolic volume measured by was significantly larger (4.5%) than (P < 0.001); this also case systolic (15.0%, P...
<h3>Importance</h3> Establishment of an optimal cancer surveillance program is important to reduce cancer-related morbidity and mortality in individuals with Li-Fraumeni syndrome, a rare, highly penetrant predisposition syndrome. <h3>Objective</h3> To determine the feasibility efficacy comprehensive screening regimen using multiple radiologic techniques, including rapid whole-body magnetic resonance imaging (MRI) laboratory measurements. <h3>Design, Setting, Participants</h3> Baseline...
The purpose of this study was to evaluate in a multicenter dataset the performance an artificial intelligence (AI) detection system with attention mapping compared multiparametric MRI (mpMRI) interpretation prostate cancer.