A5033732510- Histiocytic Disorders and Treatments
- Reconstructive Surgery and Microvascular Techniques
- Breast Implant and Reconstruction
- Extracellular vesicles in disease
- Eosinophilic Disorders and Syndromes
- interferon and immune responses
- Mobile Health and mHealth Applications
- Nerve injury and regeneration
- Knee injuries and reconstruction techniques
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Multisensory perception and integration
- 14-3-3 protein interactions
- Facial Trauma and Fracture Management
- Diversity and Career in Medicine
- LGBTQ Health, Identity, and Policy
- Cognitive Science and Education Research
- Bone fractures and treatments
- Body Contouring and Surgery
- Parvovirus B19 Infection Studies
- Cutaneous lymphoproliferative disorders research
- Tumors and Oncological Cases
- Rabies epidemiology and control
- Venomous Animal Envenomation and Studies
- Facial Nerve Paralysis Treatment and Research
- Muscle activation and electromyography studies
Saint Louis University
2021-2025
October 6 University
2023
Conference Board
2023
University Medical Center
2021
National Human Genome Research Institute
2016-2020
National Institutes of Health
2016-2020
University of Tennessee Health Science Center
2018-2019
University of Tennessee at Knoxville
2019
University of Virginia
1926-2015
California University of Pennsylvania
1926
Erdheim-Chester Disease (ECD) is a rare, potentially fatal, multi-organ myeloid neoplasm occurring mainly in adults. The diagnosis established by clinical, radiologic, and histologic findings; ECD tumors contain foamy macrophages that are CD68+, CD163+, CD1a-, frequently S100-. purpose of this report to describe the clinical molecular variability ECD. Sixty consecutive patients (45 males, 15 females) were prospectively evaluated at NIH Clinical Center between 2011 2015. Comprehensive imaging...
Little consensus exists regarding the proper timing of mandibular fracture fixation. Given proximity oral flora to mandible, many surgeons advocate for early fixation mitigate infection risk. This retrospective study evaluates safety treating mandible fractures in a subacute period. After institutional review board approval, analysis was performed all presented single center from 2013 2023. Patient, injury, medical, and operative details were reviewed. Area deprivation index (ADI) used...
To characterize the spectrum of neurologic involvement in Erdheim-Chester Disease (ECD), a treatable inflammatory neoplasm histiocytes.Sixty-two patients with ECD were prospectively enrolled natural history study that facilitated collection clinical, imaging, laboratory, neurophysiologic, and pathologic data.Ninety-four percent had abnormalities on examination or 22% symptoms as initial presentation ECD. The most common findings cognitive impairment, peripheral neuropathy, pyramidal tract...
Insurance coverage of postmastectomy breast reconstruction is mandated in America, regardless reconstructive modality. Despite enhanced patient-reported outcomes, autologous utilized less than nonautologous nationally. Lower reimbursement from Medicare and Medicaid may disincentivize autologous-based reconstruction. This study examines the impact insurance sociodemographic factors on reconstruction.A retrospective analysis Healthcare Cost Utilization Project National Inpatient Sample...
Limited information is available regarding interstitial lung disease (ILD) in Erdheim–Chester (ECD), a rare multisystemic non-Langerhans cell histiocytosis. Sixty-two biopsy-confirmed ECD patients were divided into those with no ILD (19.5%), minimal (32%), mild (29%), and moderate/severe based on computed tomography (CT) findings. Dyspnea affected at least half of the or ILD. Diffusion capacity was significantly reduced Disease severity inversely correlated pulmonary function measurements;...
Objectives In October 2021, the US Food and Drug Administration mandated patient decision checklists new labeling for breast implants with goal of improving informed decision-making process patients considering implantation. Given growing concerns over implant–associated anaplastic large cell lymphoma, squamous carcinoma, implant illness, should be able to easily review these resources make a fully when surgery. This study seeks elucidate accessibility, therefore utility newly literature...
A man who had undergone forebrain commissurotomy (L.B.) and a with agenesis of the corpus callosum (R.B.) judged whether pairs spatially separated lights were successive or simultaneous. Stimulus onset asynchronies (SOAs) 0, 17, 33, 50, 67, 83, 117, 150 ms. When in opposite visual fields, SOA at which discrimination first reached level significantly above chance was ms for L.B., 67 R.B., 33 "normal" participants. Results parallel evidence from reaction time studies estimates interhemispheric...
Erdheim-Chester disease (ECD) is a rare non-Langerhans cell histiocytosis characterized by uncontrolled inflammation resulting in fibro-inflammatory damage of multiple organs, including the hypothalamic-pituitary-adrenal (HPA) axis. Glucocorticoid insufficiency may occur and associated with an increased burden risk adrenal crisis. Sixty-one ECD subjects (46 males, age 54.3 ± 10.8 years) were evaluated; 56.1% (32/57) harbored somatic activating BRAF V600E variant. Adrenal gland sellar or...
AMERICAN ASSOCIATION OF ANATOMISTSof the cystic duct, to end in lymph nodes at head of pancreas.Lymph channels from liver empty into these draining ducts but contrary prevailing opinion, no direct connections between lymphatics and plexuses gall bladder were obtained. DEMONSTRATIONS1. Tracings, graphs, tables illwtrating form, position, involution median fontanelles living human infant.F.
Abstract Recently, mandated FDA patient decision checklists were developed with the goal of improving informed decision-making process for patients considering breast implants. However, these are written at reading levels far higher than recommended by National Institutes Health and American Medical Association. This study aims to improve accessibility, therefore, utility literature average implant using assistance artificial intelligence (AI). Patient obtained from 3 most utilized...
The management of breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) has been well established. However, there is minimal data and significant variability in the asymptomatic textured implant (ATI) patients.The purpose this study was to survey members Aesthetic Society on ATI patients order understand trends practice patterns.Members were queried via an electronic regarding patients. Anonymous responses collected by QualtricsXM (SAP, Walldorf, Germany) software. Descriptive...
Diacylglycerol kinases (DGKs) are a family of highly conserved enzymes that promiscuously responsive to growth factors and other mitogenic signaling cascades. DGKs activated by binding Ca2+ phosphoserine, catalyze conversion diacylglycerol (DAG) phosphatidic acid (PA). PA has multiple effects on downstream cellular signaling, while can associate with scaffolding proteins, or undergo degradation translocation the nucleus through atypical localization signals thereby promote cell division...
OBJECTIVE: To characterize the neurologic features of Erdheim-Chester Disease (ECD). BACKGROUND: ECD is a non-langerhans histiocytosis characterized by macrophage accumulation in bone, kidneys, retroperitoneum, orbits, pituitary stalk, and nervous system. It distinguished from Rosai-Dorfman Juvenile Xanthogranuloma presence CD68+, CD163+, CD1a-, CD207-, S100+/-, anti-factor XIIIa+ foamy macrophages on biopsy. Treatments include immunomodulators BRAF/MAP kinase inhibitors. A retrospective...
BACKGROUND: Diacylglycerol Kinase Alpha (DGKa) inhibition with the known inhibitor R59022 results in strong cytotoxicity against glioblastoma cells vitro.The use of vivo orthotopic xenografts was less successful due to limited solubility, short serum half-life, and possible low penetration blood-brain barrier.In addition, pro-immune effect on DGKa T-cells is unlikely occur immunocompromised mice.We show combined oral treatment related compound ritanserin temozolomide markedly prolonged...
OBJECTIVE: To describe the intracranial pathology found in neurologic Erdheim Chester Disease (ECD). BACKGROUND: ECD is a rare non-Langerhans cell histiocytosis involving multiple organs including CNS, where presentation can resemble primary malignancy, lymphoma or inflammatory demyelination. Diagnosis requires finding CD68+, CD163+, CD1a-, CD207-, S100+/-, Factor XIIIa+ foamy macrophages. BRAF and other RAS genes mutations are associated with this disease. CNS histology rarely poorly...