A5006028337- Genomics and Phylogenetic Studies
- Pharmacogenetics and Drug Metabolism
- Bioinformatics and Genomic Networks
- Bone and Dental Protein Studies
- Ferroptosis and cancer prognosis
- Computational Drug Discovery Methods
- Gene expression and cancer classification
- Glioma Diagnosis and Treatment
- Acute Lymphoblastic Leukemia research
- Dental Trauma and Treatments
- Genetic diversity and population structure
- Chronic Myeloid Leukemia Treatments
- Renal cell carcinoma treatment
- Bone Tissue Engineering Materials
- Single-cell and spatial transcriptomics
- Advanced Proteomics Techniques and Applications
- CRISPR and Genetic Engineering
- RNA and protein synthesis mechanisms
- Cancer Genomics and Diagnostics
- Acute Myeloid Leukemia Research
- Mitochondrial Function and Pathology
- Prostate Cancer Treatment and Research
- Analytical Chemistry and Chromatography
- Tissue Engineering and Regenerative Medicine
- Periodontal Regeneration and Treatments
Chongqing Medical University
2022-2024
Johns Hopkins University
2018-2021
Johns Hopkins Medicine
2021
UNSW Sydney
2016-2017
To elucidate the deregulated functional modules that drive clear cell renal carcinoma (ccRCC), we performed comprehensive genomic, epigenomic, transcriptomic, proteomic, and phosphoproteomic characterization of treatment-naive ccRCC paired normal adjacent tissue samples. Genomic analyses identified a distinct molecular subgroup associated with genomic instability. Integration proteogenomic measurements uniquely protein dysregulation cellular mechanisms impacted by alterations, including...
We developed OmicsMapNet approach to take advantage of existing deep leaning frameworks analyze high-dimensional omics data as 2-dimensional images. The individual samples were first rearranged into 2D images in which molecular features related functions, ontologies, or other relationships organized spatially adjacent and patterned locations. Deep learning neural networks trained classify the Molecular informative classes different phenotypes subsequently identified. As an example, we used...
Aberrant stem cell-like gene regulatory networks are a feature of leukaemogenesis. The ETS-related (ERG), an important regulator normal haematopoiesis, is also highly expressed in T-ALL and acute myeloid leukaemia (AML). However, the transcriptional regulation ERG leukaemic cells remains poorly understood. In order to discover regulators ERG, we employed quantitative mass spectrometry-based method identify factors binding 321 bp +85 cell enhancer region MOLT-4 KG-1 AML cells. Using this...
Current PSA-based tests used to detect prostate cancer (PCa) lack sufficient specificity, leading significant overdetection and overtreatment. Our previous studies showed that serum fucosylated PSA (Fuc-PSA) soluble TEK receptor tyrosine kinase (Tie-2) had the ability predict aggressive (AG) PCa. Additional biomarkers are needed address this clinical problem.
Human-treated dentin matrix (hTDM) has recently been studied as a natural extracellular matrix-based biomaterial for pulp regeneration. However, porcine-treated (pTDM) is potential alternative scaffold due to limited availability. there dearth of information regarding the protein composition and underlying molecular mechanisms pTDM.Methods: hTDM pTDM were fabricated using human porcine teeth, respectively, their morphological characteristics examined scanning electron microscopy. Stem cells...
// Shiyong Ma 1 , Ranjeeta Menon 1, 2 Rebecca C. Poulos and Jason W.H. Wong Prince of Wales Clinical School, Faculty Medicine, UNSW Sydney, Australia Present address: Centre for Research Excellence in Tuberculosis the Marie Bashir Institute Infectious Diseases Biosecurity, The University Sydney Microbiology – Public Health, Westmead Hospital, NSW, Correspondence to: Wong, email: jason.wong@unsw.edu.au Keywords: Proteogenomics; phosphoproteomics; RNA-seq; Jurkat; splicing factor mutation...
Drug-likeness is a vital consideration when selecting compounds in the early stage of drug discovery. A series drug-like properties are needed to predict drug-likeness given compound and provide useful guidelines increase likelihood converting lead into drugs. Experimental physicochemical properties, pharmacokinetic/toxicokinetic maximum dosages approved small-molecule drugs from multiple text-based unstructured data resources have been manually assembled, curated, further digitized...
Genetically modified organisms (GMOs) can be generated to model human genetic disease or plant resistance, and they have contributed the exploration understanding of gene function, physiology, onset drug target discovery. Here, PertOrg (http://www.inbirg.com/pertorg/) was introduced provide multilevel alterations in GMOs. Raw data 58 707 transcriptome profiles associated information, such as phenotypic alterations, were collected curated from studies involving vivo perturbation (e.g....
BackgroundMost studies used animal serum-containing medium for bioengineered-root regeneration, but ethical and safety issues raised by serum are a potentially significant risk clinical use. Thus, this study aimed to find safer method regeneration.MethodsThe biological properties of human dental pulp stem cells (hDPSCs) cultured in component-free (ACF) or (5%, 10% medium, SCM) were compared vitro. hDPSCs three-dimensional (3D) environment with human-treated dentin matrix (hTDM). The capacity...
Abstract Background Diffuse intrinsic pontine gliomas (DIPGs) and other H3K27M-mutated diffuse midline (DMGs) are brain tumors that primarily affect children. Radiotherapy is the standard of care but only provides temporary symptomatic relief due to radioresistance. Although hypoxia a major driver radioresistance in tumors, there no definitive evidence DIPGs hypoxic. often contain histone mutations, which alter tumor metabolism also associated with Our objective was identify metabolic...