A5074129051- Appendicitis Diagnosis and Management
- Intestinal Malrotation and Obstruction Disorders
- Employment and Welfare Studies
- Breast Cancer Treatment Studies
- Epigenetics and DNA Methylation
- Cervical Cancer and HPV Research
- Cancer-related molecular mechanisms research
- Intraperitoneal and Appendiceal Malignancies
- Diverticular Disease and Complications
- Colorectal Cancer Surgical Treatments
- Medical Imaging Techniques and Applications
- Breast Lesions and Carcinomas
- Workplace Health and Well-being
- Global Health Workforce Issues
- Gastric Cancer Management and Outcomes
- Cancer-related gene regulation
- Neurological disorders and treatments
- Gastrointestinal Tumor Research and Treatment
- Retirement, Disability, and Employment
- Hereditary Neurological Disorders
- Genital Health and Disease
- Stress and Burnout Research
- Migration, Health and Trauma
- RNA modifications and cancer
- Hepatocellular Carcinoma Treatment and Prognosis
Agència de Salut Pública de Catalunya
2012-2025
Hospital de Sant Pau
2025
University of Southern California
2022-2023
Southern California University for Professional Studies
2022
Secretaria de Salud
2019
Pompeu Fabra University
2019
Consortium for Health and Social Catalonia
2013-2016
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
2011-2012
Agencia de Salud Pública de Barcelona
2012
Universitat Autònoma de Barcelona
2007-2009
ABSTRACT Integration of human papillomavirus type 16 (HPV-16) into the host DNA has been proposed as a potential marker cervical neoplastic progression. In this study, quantitative real-time PCR (qRT-PCR) was used to examine physical status HPV-16 in 126 carcinoma situ and 92 invasive cancers. Based on criteria applied results from qRT-PCR assay, characterized cases episomal (61.9%), mixed (i.e., integrated; 29.4%), integrated (8.7%) forms. cancer samples, similarly (39.1%), (45.7%), (15.2%)...
Cervical cancer (CC), a leading cause of cancer-related deaths in women worldwide, has been causally linked to genital human papillomavirus (HPV) infection. Although host genetic alterations have identified, molecular basis CC development is still poorly understood. We examined the role promoter hypermethylation, an epigenetic alteration that associated with silencing tumor suppressor genes cancer, by studying 16 gene promoters 90 cases. found high frequency methylation CDH1, DAPK, RARB, and...
Abstract Patients with advanced stage invasive cervical cancer (CC) exhibit highly complex genomic alterations and respond poorly to conventional treatment protocols. In our efforts understand the molecular genetic basis of CC, we examined role Fanconi Anemia (FA)-BRCA pathway. Here, show that FANCF gene is disrupted by either promoter hypermethylation and/or deregulated expression in a majority CC. Inhibition DNA methylation histone deacetylases induces re-expression CC cell lines....
PURPOSE: Our goal was to compare initial operative and nonoperative management for periappendiceal abscess complicating appendicitis. METHODS: This study is a retrospective review of 155 consecutive patients with appendicitis complicated by treated between 1992 1998. Eighty-eight were initially nonoperatively, 67 operatively. All had localized abdominal tenderness either computed tomography or intraoperative documentation an abscess. RESULTS: patient population consisted 107 males 48...
Carcinoma of uterine cervix is the second most common cancers among women worldwide. Combined radiation and chemotherapy choice treatment for advanced stages disease. The prognosis poor, with a five-year survival rate ranging from about 20–65%, depending on stage Therefore, genetic characterization essential understanding biology clinical heterogeneity in cervical cancer (CC). We used genome-wide screening method – comparative genomic hybridization (CGH) to identify DNA copy number changes...
In 2002 the Breast Health Global Initiative (BHGI) convened a panel of breast cancer experts and patient advocates to develop consensus recommendations for diagnosing in countries with limited resources. The agreed on need pathologic diagnosis, based microscopic evaluation tissue specimens, before initiating treatment. discussed options diagnosis (fine-needle aspiration biopsy, core needle surgical biopsy) concluded that choice among these methods should be available tools expertise....
Following a legionnaire's disease outbreak in Barcelona 2022, sport fields' sprinklers were identified as potential sources of Legionella infection. The Agency Public Health inspected all 40 urban municipal sports fields the city. was found 55% them, including pneumophila serotype 1 11 samples. There no statistically significant differences for detection according to installation characteristics.These findings prompted implementation set preventive measures risk mitigation and specific...
Laparoscopic sigmoid colectomy (LSC) for diverticular disease accounts a limited number of laparoscopic colon cases performed nationally because the technical challenge it presents. Our objective was to determine feasibility and impact approach in elective compare these results with those open approach. Twenty colectomies (LSCs) were diverticulitis between April 1992 July 1999 at university-affiliated urban hospital. A case-control study comparing LCS matched control group conventional...
Context Interstitial cells of Cajal (ICCs), also known as pacemaker cells, are in the gastrointestinal tract that play a role control gut motility. The ICCs express c-kit proto-oncogene encoding type III tyrosine kinase (KIT) receptor, ligand is stem cell factor (SCF). maturation dependent on SCF-KIT interaction. cellular origin, differentiation, nomenclature, and prognosis stromal tumors (GISTs) controversial. Objective To test hypothesis GISTs originate from CD34-positive differentiate...
From the beginning of 2007 until end 2011, 146 cases lymphogranuloma venereum (LGV) were notified to Barcelona Public Health Agency. Some 49% them diagnosed and reported in mainly men who have sex with men. Almost half them, 32 cases, between July September. This cluster represents largest since 2004. article presents ongoing outbreak LGV Barcelona.
Abstract Context.—Interstitial cells of Cajal (ICCs), also known as pacemaker cells, are in the gastrointestinal tract that play a role control gut motility. The ICCs express c-kit proto-oncogene encoding type III tyrosine kinase (KIT) receptor, ligand is stem cell factor (SCF). maturation dependent on SCF-KIT interaction. cellular origin, differentiation, nomenclature, and prognosis stromal tumors (GISTs) controversial. Objective.—To test hypothesis GISTs originate from CD34-positive...
The purpose of this study was to review and characterize the indications early outcomes abdominoperineal resection (APR) when used in a colorectal practice an academic setting. Data collected from charts all patients undergoing APR retrospective manner. included demographic information details regarding clinical presentation. Operative factors, postoperative course, morbidity mortality were evaluated. Forty-four treated with between years 1992 2004. for operation primary rectal cancer (n =...
Botulism is a severe neuroparalytic disorder that can be potentially life-threatening. In Barcelona, Spain, no outbreaks had been reported in the past 25 years. However, September 2011, two occurred involving different families. A rare case of Clostridium baratii which produced neurotoxin F outbreak was detected five family members who shared lunch, and several days before another affected by C. botulinum toxin probably present homemade pâté.