A5059172875- Pancreatic and Hepatic Oncology Research
- Cancer Cells and Metastasis
- PI3K/AKT/mTOR signaling in cancer
- Cancer Research and Treatments
- Protease and Inhibitor Mechanisms
- Curcumin's Biomedical Applications
- Immunotherapy and Immune Responses
- Immune cells in cancer
- Cell death mechanisms and regulation
- Pancreatic function and diabetes
- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Peptidase Inhibition and Analysis
- Nanoplatforms for cancer theranostics
- Single-cell and spatial transcriptomics
- Cell Adhesion Molecules Research
- Cancer-related Molecular Pathways
- CAR-T cell therapy research
- TGF-β signaling in diseases
- Cancer, Stress, Anesthesia, and Immune Response
- RNA Interference and Gene Delivery
- Growth Hormone and Insulin-like Growth Factors
- Cancer-related gene regulation
- Garlic and Onion Studies
- Wnt/β-catenin signaling in development and cancer
The University of Texas MD Anderson Cancer Center
2024
Uniformed Services University of the Health Sciences
2023
Henry M. Jackson Foundation
2023
Jackson Foundation
2023
Albert Einstein College of Medicine
2017-2022
Montefiore Medical Center
2022
Rutgers, The State University of New Jersey
2019
Skåne University Hospital
2015-2018
Lund University
2015-2018
University of Madras
2009-2014
The inflammatory milieu plays an important role in colon cancer development and progression. Previously, we have shown that tumor-associated macrophages (TAMs), component of the tumor microenvironment, are enriched tumors compared with normal tissue confer a poorer prognosis. In present study, found matrix metallopeptidase-9 (MMP-9), which degrades extracellular proteins, was increased biopsies from patients mouse xenografts SW480 cell-derived tumors. cells exposed to M2-like...
Pancreatic ductal adenocarcinoma (PDAC) is a highly metastatic disease. Tumors are poorly immunogenic and immunosuppressive, preventing T cell activation in the tumor microenvironment. Here, we present microbial-based immunotherapeutic treatment for selective delivery of an tetanus toxoid protein (TT 856-1313 ) into PDAC cells by attenuated Listeria monocytogenes . This reactivated preexisting TT-specific memory to kill infected mice. Treatment KrasG12D,p53R172H, Pdx1-Cre (KPC) mice with -TT...
Abstract Urokinase‐type plasminogen activator (uPA) is a serine protease that involved in cancer progression, especially invasion and metastasis including prostate cancer. uPA activation mediated by transactivation of uPAR epidermal growth factor receptor (EGF‐R) progression. Prostate (PC‐3) cells have highly invasive capacity they express gene. PC‐3 are treated with quercetin, which inhibits migration cells. Quercetin downregulates uPA, EGF, EGF‐R mRNA expressions. cell survival β‐catenin,...
BACKGROUND: Breast cancer is the most common affecting women in world today. Matrix metalloproteinases (MMPs) are a family of endopeptidases that can degrade extracellular matrix proteins and promote cell invasion metastasis. MMPs differentially expressed their expressions often associated with poor prognosis for patients. OBJECTIVE: The aim this study to investigate compare expression different grades human breast tissues normal tissues. PATIENTS AND METHODS: We collected 39 samples (24...
// Dinesh Chandra 1 , Benson Chellakkan Selvanesan Ziqiang Yuan 2 Steven K Libutti Wade Koba 3 Amanda Beck 4 Kun Zhu Arturo Casadevall 5 Ekaterina Dadachova 6 Claudia Gravekamp Albert Einstein College of Medicine, Department Microbiology and Immunology, Bronx, NY 10461, USA Montefiore Medical Center, Arts Pavilion, MMC-MAP, 10467, Radiology, MRRC, Pathology, Michael F. Price Johns Hopkins Bloomberg School Public Health, Molecular Baltimore, MD 21205, Radiology/Department Correspondence to:...
Breast cancer is the most common affecting women in world today. Matrix metalloproteinases (MMPs) are a family of endopeptidases that can degrade extracellular matrix proteins and promote cell invasion metastasis. MMPs differentially expressed their expressions often associated with poor prognosis for patients.The aim this study to investigate compare expression different grades human breast tissues normal tissues.We collected 39 samples (24 grade II 15 III) along 16 from outside tumor...
Colorectal cancer is one of the most common types cancers worldwide. Recent studies have identified cancer-initiating cells (CICs) as a subgroup replication-competent in development colorectal cancer. Although it understood that an inflammation-rich tumor microenvironment presumably supports CIC functions, contributory factors are not very well defined. The present study advances our understanding role eicosanoids leukotriene D4 (LTD4) and prostaglandin E2 (PGE2) tumorigenic ability CICs...
The insulin‐like growth factor I (IGF‐I) signalling pathway contributes a major role on various cancer cell proliferation, survival and cycle. present study was aimed to investigate the effect of nimbolide IGF cycle arrest in MCF‐7 MDA‐MB‐231 breast lines. protein expression molecules levels assessed by western blot analysis. In order interaction IGF‐1 pathway, IGF‐I phosphoinositide 3‐kinase (PI3K) inhibitor (LY294002) were used treat cells. Further, analysed flow cytometry. significantly...
Curcumin, the major active principle of Curcuma longa, is one promising, plant-derived, chemopreventive agents being studied for its anticarcinogenic and antioxidant properties. Hence, in our study, we aimed at testing antiproliferative efficacy an o-hydroxyl substituted analog curcumin, bis demethoxy curcumin (BDMC-A), comparing with that curcumin. BDMC-A was synthesised a yield 78% 98% purity. Hep-2 cells MTT cell viability assay were used to examine proliferation. LDH counts performed...
Cancer immunotherapy is one of the most promising and benign therapies against metastatic cancer. However, cancer patients are old elderly react less efficient to vaccines than young adults, due T cell unresponsiveness. Here we present data vaccination in mice with breast (4T1 model). We tested adaptive innate immune responses foreign antigens (Listeria-derived) self-antigens (tumor-associated (TAA)) their contribution elimination metastases at age. Three different protocols were Listeria: a...
Abstract Transforming growth factor‐β1 (TGF‐β1) is a crucial molecule for stimulation of breast cancer invasion and formation bone metastases. The molecular mechanisms how TGF‐β1 mediates these effects have yet to be completely determined. We found that activating transcription factor‐3 (ATF‐3) strongly stimulated its level sustained by in highly invasive metastatic human (MDA‐MB231) mouse mammary pad tumor cells (r3T). ATF‐3 also overexpressed primary tissue. Overexpression increased normal...
Treatments for pancreatic ductal adenocarcinoma are poorly effective, at least partly due to the tumor's immune-suppressive stromal compartment. New evidence of positive effects on immune responses in tumor microenvironment (TME), compelled us test combination gemcitabine (GEM), a standard chemotherapeutic cancer, with nicotinamide (NAM), amide form niacin (vitamin B3), mice cancer. Various mouse models that is, orthotopic Panc-02 and KPC (KrasG12D, p53R172H, Pdx1-Cre) grafts, were treated...
Lymphocyte antigen 6K (LY6K) is a small GPI-linked protein that normally expressed in testes. Increased expression of LY6K significantly associated with poor survival outcomes many solid cancers, including cancers the breast, ovary, gastrointestinal tract, head and neck, brain, bladder, lung. required for ERK-AKT TGF-β pathways cancer cells vivo tumor growth. In this report, we describe novel role mitosis cytokinesis through aurora B kinase its substrate histone H3 signaling axis. Further,...
Pancreatitis and pancreatic ductal adenocarcinoma (PDAC) are grave illnesses with high levels of morbidity mortality. Intravital imaging (IVI) is a powerful technique for visualizing physiological processes in both health disease. However, the application IVI to murine pancreas presents significant challenges, as it deep, compliant, visceral organ that difficult access, easily damaged susceptible motion artefacts. Existing windows stabilizing during have unfortunately shown poor stability...
NSC243928 induces cell death in triple-negative breast cancer cells a LY6K-dependent manner. has been reported as an anti-cancer agent the NCI small molecule library. The molecular mechanism of treatment tumor growth syngeneic mouse model not established. With success immunotherapies, novel drugs that may elicit anti-tumor immune response are high interest development to treat solid cancer. Thus, we focused on studying whether vivo mammary models 4T1 and E0771. We observed induced...