A5027708417- Chronic Myeloid Leukemia Treatments
- Acute Myeloid Leukemia Research
- RNA Interference and Gene Delivery
- Curcumin's Biomedical Applications
- Microbial infections and disease research
- Synthesis and biological activity
- RNA modifications and cancer
- Click Chemistry and Applications
- RNA Research and Splicing
- Cancer therapeutics and mechanisms
- Epigenetics and DNA Methylation
- Biochemical and Molecular Research
- Tuberculosis Research and Epidemiology
- Developmental Biology and Gene Regulation
- Plant Genetic and Mutation Studies
- Microtubule and mitosis dynamics
- Histone Deacetylase Inhibitors Research
- Bacterial Infections and Vaccines
- CRISPR and Genetic Engineering
- RNA regulation and disease
- Immune Cell Function and Interaction
- Nutrition, Genetics, and Disease
- Fungal Plant Pathogen Control
- PI3K/AKT/mTOR signaling in cancer
- Single-cell and spatial transcriptomics
Institute of Life Sciences
2021-2022
All India Institute of Medical Sciences
2021-2022
Sharda University
2019
Pondicherry University
2013-2018
Moffitt Cancer Center
2017
National Research Centre on Plant Biotechnology
2014
Jawaharlal Nehru University
2013
AstraZeneca (United Kingdom)
2012
Savitribai Phule Pune University
2006
Abstract The inhibition of FMS-like tyrosine kinase 3 (FLT3) activity using small-molecule inhibitors has emerged as a target-based alternative to traditional chemotherapy for the treatment acute myeloid leukemia (AML). In this study, we report use structure-based virtual screening (SBVS), computer-aided drug design technique identification new chemotypes FLT3 inhibition. For purpose, homology modeling (HM) DFG-in structure was carried two template structures, including PDB ID: 1RJB (DFG-out...
Targeting persistent tubercule bacilli has become an important challenge in the development of anti-tuberculous drugs. As glyoxylate bypass is essential for bacilli, interference with it holds potential designing new antibacterial We have developed kinetic models tricarboxylic acid cycle and Escherichia coli Mycobacterium tuberculosis, studied effects inhibition various enzymes M. tuberculosis model. used E. to validate pathway-modeling protocol showed that changes metabolic flux can be...
Chronic myeloid leukemia (CML) is caused by chromosomal rearrangement resulting in the expression of Bcr-Abl fusion protein with deregulated Abl tyrosine kinase activity. Approved drugs - imatinib, dasatinib, nilotinib, and ponatinib target ATP-binding site kinase. Even though these are initially effective, long-term usefulness limited development resistance. To overcome this problem, targeting allosteric kinase, which remote from found to be a useful strategy. In study, structure-based...
The methylerythritol phosphate (MEP) pathway of Plasmodium falciparum (P. falciparum) has become an attractive target for anti-malarial drug discovery. This study describes a kinetic model this pathway, its use in validating 1-deoxy-d-xylulose 5-phosphate reductoisomerase (DXR) as from the systemic perspective, and additional identification, using metabolic control analysis silico inhibition studies. In addition to DXR, synthase (DXS) can be targeted because it is first enzyme highest flux...
HIV-1 evades host defence through mutations and recombination events, generating numerous variants in an infected patient. These with undiminished virulence can multiply rapidly order to progress AIDS. One of the targets intervene replication is trans-activator transcription (Tat), a major regulatory protein that transactivates long terminal repeat (LTR) promoter its interaction trans-activation response (TAR) RNA. In this study, patients (n=120) from North India revealed Ser46Phe (20%)...
Mycobacterium tuberculosis(Mtu), a successful pathogen, has developed resistance against the existing anti-tubercular drugs necessitating discovery of with novel action. Enzymes involved in peptidoglycan biosynthesis are attractive targets for antibacterial drug discovery. The bifunctional enzyme mycobacterial GlmU (Glucosamine 1-phosphate N-acetyltransferase/ N-acetylglucosamine-1-phosphate uridyltransferase) been target Its C- and N- terminal domains catalyze acetyltransferase (rxn-1)...
A major cause of morbidity and mortality in patients with cancer is infection. Since the introduction Haemophilus influenzae type b (Hib) vaccine United States 1990s, invasive H infection has become less common. We report on 5 literature review was also performed dominant subtype clinical features associated concomitant cancer. Of 17 cases found literature, had hematological malignancies 1 case each thymoma, schwannoma, teratoma, pancreatic, Merkel cell, pharyngeal, laryngeal, rectal...
Thrombotic microangiopathy syndromes consist of a collection disorders with varied etiology that share common clinical and pathological features. Although thrombotic is rare, it associated significant morbidity mortality. Without early recognition intervention, the prognosis disease poor. This report illustrates case 56-year-old man advanced-stage metastatic pancreatic cancer who presented hemolytic uremic syndrome gemcitabine use. His condition was managed eculizumab, monoclonal antibody,...