A5036231973- Epilepsy research and treatment
- Pharmacological Effects and Toxicity Studies
- Neuroscience and Neuropharmacology Research
- Psychosomatic Disorders and Their Treatments
- Schizophrenia research and treatment
- EEG and Brain-Computer Interfaces
- Mental Health and Psychiatry
- Neurological disorders and treatments
- Neural dynamics and brain function
- Genetics and Neurodevelopmental Disorders
- Neurological and metabolic disorders
- Electroconvulsive Therapy Studies
- Neurology and Historical Studies
- Bipolar Disorder and Treatment
- Neuroscience and Music Perception
- Neurobiology of Language and Bilingualism
- Autism Spectrum Disorder Research
- Treatment of Major Depression
- Spatial Neglect and Hemispheric Dysfunction
- Glycogen Storage Diseases and Myoclonus
- Vestibular and auditory disorders
- Diet and metabolism studies
- Meningioma and schwannoma management
- Anesthesia and Sedative Agents
- Ophthalmology and Eye Disorders
Aichi Medical University
2015-2024
The University of Tokyo
2021
Seirei Hamamatsu General Hospital
2021
Aichi University
2017
Aichi Medical University Hospital
2010-2017
Utano Hospital
1994-2007
Kyushu University
2002
National Institute of Mental Health
2001
Meitetsu Hospital
2000
Epilepsy Foundation
1991
In order to address the major impact on quality of life and epilepsy management caused by associated neuropsychiatric conditions, an international consensus group epileptologists met with aim developing clear evidence-based practice-based statements provide guidance these conditions. Using a Delphi process, this prioritized list key areas. These included: depression, anxiety, psychotic disorders, nonepileptic seizures, cognitive dysfunction, antiepileptic drug (AED)–related neurobehavioral...
Proinflammatory cytokines, including interleukin (IL)-1beta, are known to modulate effects of neurotoxic neurotransmitters discharged during excitation or inflammation in the central nervous system (CNS). They also regulate development glial scars at sites CNS injury. To elucidate a genetic predisposition temporal lobe epilepsy with hippocampal sclerosis (TLE-HS+), we studied polymorphisms IL-1beta, IL-1alpha, and IL-1 receptor antagonist (IL-1RA) genes 50 patients TLE-HS+ 112 controls....
We studied 30 patients with postictal psychosis and compared them 33 acute interictal 25 chronic psychosis. All had either complex partial seizures (CPS) or EEG temporal epileptogenic foci. Patients a high incidence of psychic auras nocturnal secondarily generalized seizures. The most striking feature that distinguished from both psychoses was phenomenological: the relatively frequent occurrence grandiose delusions as well religious in setting markedly elevated moods feeling mystic fusion...
An international consensus clinical practice statement issued in 2011 ranked psychogenic nonepileptic seizures (PNES) among the top three neuropsychiatric problems. ILAE PNES Task Force was founded and initially charged with summarizing current state of art terms diagnosis treatment, resulting two publications. The first described different levels diagnostic certainty. second summarized knowledge management approaches. present paper summarizes an workshop that focused on understanding around...
Studies from a small number of countries suggest that patients with psychogenic nonepileptic seizures (PNES) have limited access to diagnostic and treatment services. The PNES Task Force the International League Against Epilepsy (ILAE) carried out 2 surveys explore diagnosis around world.A short survey (8 questions) was sent all 114 chapters ILAE. A longer (36 completed by healthcare professionals who see seizures. Questions were separated into 5 sections: professional role, methods,...
Summary: Purpose: To confirm the high frequency of interleukin (IL)‐1β‐511T allele occurrence in patients with temporal lobe epilepsy (TLE) and hippocampal sclerosis (HS), special attention given to impact prolonged febrile convulsions (PFCs) on IL‐1β genotype distribution. Methods: Patients evidence unilateral HS magnetic resonance (MR) images were chosen as study subjects (TLE+HS; n = 66) . Other essentially normal MRI findings or only foreign tissue (TLE without HS; TLE‐HS; 64 ), those...
Carbamazepine, a commonly used antiepileptic drug, is one of the most common causes cutaneous adverse drug reactions (cADRs) worldwide. The allele HLA-A*31:01 reportedly associated with carbamazepine-induced cADRs in Japanese and European populations; however, clinical utility has not been evaluated.To assess use genetic screening to identify individuals at risk cADRs.This cohort study was conducted across 36 hospitals Japan from January 2012 November 2014 among 1202 patients who had deemed...
Migraine-like features sometimes characterize the headache that follows epileptic seizure (postictal headache, PIH). We compared patients with different types of epilepsy to investigate association between migraine-like PIH and type. Subjects comprised 364 partial epilepsy. Epilepsy were temporal lobe (TLE, n = 177), frontal (FLE, 116), occipital (OLE, 71). Patients participated in a structured interview pertaining as well interictal family history migraine. Headaches classified according...
We sought to examine interictal psychoses based on the international epilepsy classification and DSM IV criteria, with special attention paid types as well subcategories of psychoses. One hundred thirty-two outpatients were studied, each definite evidence both psychosis clearly demarcated from postictal psychosis. compared them 2,773 other a control. Risk factors for examined within temporal lobe (TLE) group more extended symptomatic localization-related epilepsy. Further, nuclear...
We investigated the incidence of well-directed violent behavior and suicide attempts in patients with temporal lobe epilepsy, special attention to postictal psychosis.We compared 57 episodes psychosis 62 acute interictal (or alternative) 134 complex partial seizures. All were matched for age at onset seizures.The against human beings was significantly higher (23%) during psychotic than (5%) confusion (1%). Suicide also more frequent (7%) either (2%) or (0%).Our study showed that...
Summary: Purpose: Status epilepticus (SE) appears to cause cognitive dysfunction as well other serious neurologic sequelae. To confirm whether SE produces a subsequent intellectual decline, we evaluated function prospectively in adult epilepsy patients with and without SE. Methods: Of 1,685 who underwent comprehensive neuropsychological testing two national hospitals Japan, 15 experienced an episode of afterward the second examination after episode. Forty clinically matched epilepsy, but...
Summary In patients with epilepsy, coexisting psychoses, either interictal ( IIP ) or postictal PIP ), are associated serious disturbance in psychosocial function and well‐being, often require the care of a specialist. Unfortunately, evidence‐based treatment systems for psychosis epilepsy have not yet been established. This article aims to propose concise practical procedures based on currently available data international consensus statements, primarily targeting nonpsychiatrist...
Apart from the rather rare ictal psychotic events, such as non-convulsive status epilepticus, modern epileptic psychoses have been categorized into three main types; chronic and acute interictal (IIPs) postictal psychosis (PIP). Together, they comprise 95% of in patients with epilepsy (PWE). Four major questions, that is, “Is PWE a direct consequence or schizophrenia induced by epilepsy?”, homogeneous heterogeneous?”, “Does symptomatological differences related disorders?”, uniquely...
This study investigates the histories and clinical course of 111 patients who had nonlesional temporal lobe epilepsy. We compared 61 with unilateral hippocampal sclerosis (UHS group) 50 minimal change (MRI negative assessed on basis MRI. In agreement previous reports, we confirmed statistically that in UHS group strongly tended to have febrile convulsive status during early childhood or infancy habitual seizures begin at a younger age than other subset Strikingly, episodes psychoses,...
To prospectively investigate the incidence of interictal psychoses epilepsy patients, and make a comparison between those with patients schizophrenia in respect to their responses antipsychotic drugs, as well psychotic states.We undertook two-part prospective investigation. In Part I, episodes 619 were investigated, while 182 syndromes followed II, whom 59 diagnosed 13 psychoses. The Positive Negative Syndrome Scale was used for efficacy assessment.The average annual psychosis 0.42% during...