A5018558266- Disaster Response and Management
- Peroxisome Proliferator-Activated Receptors
- Sepsis Diagnosis and Treatment
- Hip disorders and treatments
- Inflammatory mediators and NSAID effects
- Immune Response and Inflammation
- Pelvic and Acetabular Injuries
- Abdominal Trauma and Injuries
- Nitric Oxide and Endothelin Effects
- Orthopaedic implants and arthroplasty
- Trauma and Emergency Care Studies
- Cardiac Arrest and Resuscitation
- Trauma Management and Diagnosis
- Ovarian cancer diagnosis and treatment
- Cancer, Lipids, and Metabolism
- Respiratory Support and Mechanisms
- Blood Coagulation and Thrombosis Mechanisms
- Venous Thromboembolism Diagnosis and Management
- Neuroscience and Neuropharmacology Research
- Gastrointestinal Tumor Research and Treatment
- Abdominal Surgery and Complications
- Intraperitoneal and Appendiceal Malignancies
- Anesthesia and Neurotoxicity Research
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- S100 Proteins and Annexins
Himeji Dokkyo University
2012-2023
The University of Tokyo
2022
Tokyo Metropolitan Hiroo Hospital
2021
Hokkaido University
1992-2020
Aichi Medical University
1995-2019
Kumamoto University
2007-2018
National Medical Research Center of Dentistry and Maxillofacial Surgery
2017
Nippon Medical School Hospital
1998-2016
Juntendo University Shizuoka Hospital
2016
Toho University
2002-2015
Background Understanding the mechanisms of non-T cell inflamed tumor microenvironment (TME) and their modulation are important to improve cancer immunotherapies such as immune checkpoint inhibitors. The involvement various immunometabolisms has recently been indicated in formation immunosuppressive TME. In this study, we investigated immunological roles stearoyl-CoA desaturase 1 (SCD1), which is essential for fatty acid metabolism, response. Methods We SCD1 by inhibition with chemical...
The types of medical care required during a disaster are determined by variables such as the cycle and nature disaster. Following flood, there exists potential for transmission water-borne diseases increased levels endemic illnesses vector-borne diseases. Therefore, consideration situation infectious must be addressed when providing relief. Japan Disaster Relief (JDR) Medical Team was sent to Mozambique where flood occurred January March 2000. team operated in Hokwe area State Gaza,...
Cardiomyocyte apoptosis contributes to cell death during myocardial infarction. One of the factors that regulate degree ischemia is amino acid taurine. To study mechanism underlying beneficial effect taurine, we examined interaction between taurine and mitochondria-mediated using a simulated model with cultured rat neonatal cardiomyocytes sealed in closed flasks. Exposure medium containing 20 mM reduced following periods varying from 24 72 h. In untreated group, for h led mitochondrial...
To investigate treatment effects of thrombomodulin alfa (TM-α) in patients with disseminated intravascular coagulation (DIC) having infection as the underlying disease, retrospective subanalysis a double-blind, randomized controlled phase 3 trial was conducted. In trial, 227 DIC (full-analysis set) and/or hematologic malignancy disease received either TM-α (0.06 mg·kg for 30 min once daily) or heparin (8 U·kg·h 24 h) 6 days using double-dummy method. Among these patients, 147 noninfectious...
AimsDoxorubicin (DOX) is one of the most effective anti-neoplastic agents; however, its clinical use limited by drug-induced cardiomyopathy. The molecular mechanisms responsible for this toxicity remain to be fully addressed. In present study, we investigated involvement atrogin-1, muscle-specific ubiquitin ligases, in DOX-induced cardiotoxicity.
Peripheral neurotoxicity is the major limiting factor for oxaliplatin therapy. Goshajinkigan (GJG), a traditional Japanese herbal medicine, was recently shown to be effective in protecting against of taxanes Japan. We retrospectively investigated effect GJG on peripheral associated with Ninety patients metastatic colorectal cancer that received FOLFOX4 or modified FOLFOX6 therapy were assigned receive one following adjuncts: oral at 7.5 g day(-1) (Group A, n = 11), intravenous...
Currently in Japan, the preferred method for blood purification patients with acute renal failure is continuous hemodiafiltration (CHDF). However, CHDF filters out various antifungal drugs such as fluconazole through large pores membrane used. Systemic fungal infection still one of main causes death and complications critically ill intensive care units (ICUs). Therefore it important to determine appropriate use agents. This study was designed evaluate influence on pharmacokinetics agent...
Abstract Introduction: The large number casualties caused by the 1995 Great Hanshin and Awaji Earthquake created a massive demand for medical care. However, as area hospitals also were damaged earthquake, they unable to perform their usual functions. Therefore, care capacity was reduced greatly. Thus, needs to: (1) transport of injured ill people out disaster-affected area; (2) dispatch teams such wide-area transfers clear. need trained provide assistance made clear after Niigata-ken Chuetsu...
350-keV He+ backscattering analysis was applied to the investigation of Ag photoinduced diffusion into As2S3 glass and proved be suitable for present purposes. Silver atoms diffuse by photoirradiation (termed ’’photodoping’’). Photodoped concentration is nearly uniform falls abruptly beyond a certain depth. The S in photodoped region equivalent that As2S3. Preirradiation before deposition enhances diffusion, which results tailing concentration. preirradiation effect disappears after long...
In mammals, germ cells undergo striking dynamic changes in DNA methylation during their development. However, the dynamics and mode of are poorly understood for short interspersed elements (SINEs) dispersed throughout genome. We investigated status mouse B1 SINEs male at different developmental stages. showed a large locus-to-locus variation methylation; loci close to RNA polymerase II promoters were hypomethylated, while most others hypermethylated. Interestingly, mutation that eliminates...
Abstract Activation of NMDA receptors has been shown to induce either neuronal cell death or neuroprotection against excitotoxicity in cultured cerebellar granule neurons vitro . We have investigated the effects pretreatment with on kainate‐induced mouse hippocampus vivo The systemic administration kainate (30 mg/kg), but not (100 induced severe damage pyramidal hippocampal CA1 and CA3 subfields 3–7 days later, without affecting dentate gyrus. An immunohistochemical study using an...