A5064842675- Child and Adolescent Psychosocial and Emotional Development
- Birth, Development, and Health
- Cognitive Abilities and Testing
- Genetic Associations and Epidemiology
- Maternal Mental Health During Pregnancy and Postpartum
- Genetics and Neurodevelopmental Disorders
- Autism Spectrum Disorder Research
- Attention Deficit Hyperactivity Disorder
- Health Systems, Economic Evaluations, Quality of Life
- Early Childhood Education and Development
- Chronic Disease Management Strategies
- Adolescent and Pediatric Healthcare
- Health disparities and outcomes
- Health, Environment, Cognitive Aging
- Family Dynamics and Relationships
- Infant Development and Preterm Care
- COVID-19 and Mental Health
- Genetic and phenotypic traits in livestock
- Bipolar Disorder and Treatment
- Family Support in Illness
- Child Nutrition and Feeding Issues
- Nutrition, Genetics, and Disease
- Homelessness and Social Issues
- Eating Disorders and Behaviors
- Statistical Methods in Clinical Trials
University of Bristol
2019-2025
Lovisenberg Diakonale Høgskole
2019-2025
Norwegian Institute of Public Health
2020-2025
University of Oslo
2023-2025
Lovisenberg Diakonale Sykehus
2020-2024
MRC Epidemiology Unit
2020-2024
Medical Research Council
2016-2023
University College London
2023
Oslo University Hospital
2023
Diacon (Canada)
2023
Little is known about the etiology of developmental change and continuity in educational achievement. Here, we study achievement from primary school to end compulsory education for 6000 twin pairs UK-representative Twins Early Development Study sample. Results showed that highly heritable across years subjects studied at (twin heritability ~60%; SNP ~30%); stable (phenotypic correlations ~0.70 ages 7 16). Twin analyses, applying simplex common pathway models, genetic factors accounted most...
Abstract Assortative mating on heritable traits can have implications for the genetic resemblance between siblings and in-laws in succeeding generations. We studied polygenic scores phenotypic data from pairs of partners ( n = 26,681), 2,170), siblings-in-law 3,905), co-siblings-in-law 1,763) Norwegian Mother, Father Child Cohort Study. Using structural equation models, we estimated associations measurement error-free latent variables. found evidence similarity educational attainment r g...
Abstract Background The Norwegian Mother, Father, and Child Cohort Study (MoBa) is a population-based pregnancy cohort, which includes approximately 114,500 children, 95,200 mothers, 75,200 fathers. Genotyping of MoBa has been conducted through multiple research projects, spanning several years; using varying selection criteria, genotyping arrays, centres. contains numerous interrelated families, necessitated the implementation family-based quality control (QC) pipeline that verifies...
Several maternal exposures during pregnancy are considered predisposing factors for offspring neurodevelopmental conditions. However, many of these may be noncausal and biased by genetic liability.
Early in life, behavioral and cognitive traits associated with risk for developing a psychiatric condition are broad undifferentiated. As children develop, these differentiate into characteristic clusters of symptoms behaviors that ultimately form the basis diagnostic categories. Understanding this differentiation process - context genetic conditions, which is highly generalized can improve early detection intervention. We modeled emotional problems from age 1.5-5 years (behavioral = score)...
Abstract Background The prevalence of youth anxiety and depression has increased globally, with limited causal explanations. Long-term physical health conditions (LTCs) affect 20–40% youth, rates also rising. LTCs are associated higher anxiety; however, it is uncertain whether observed associations or explained by unmeasured confounding reverse causation. Methods Using data from the Norwegian Mother, Father, Child Cohort Study (MoBa) National Patient Registry, we investigated phenotypic...
Summary The health of carers and others close to the patient will often be relevant economic evaluation, but it is very rarely considered in practice. This may reflect a lack understanding how spillover effect illness can appropriately quantified. In this study we used three different approaches quantify spillovers resulting from meningitis. We conducted survey 1218 family networks affected by meningitis regression modelling estimate effects. findings show that had long‐term effects on...
Although gene-environment correlation is recognized and investigated by family studies recently SNP-heritability studies, the possibility that genetic effects on traits capture environmental risk factors or protective has been neglected polygenic prediction models. We covariation between trait-associated variation identified genome-wide association (GWASs) specific exposures, controlling for overall relatedness using a genomic matrix restricted maximum-likelihood model. In UK-representative...
Abstract Background Clinicians are less likely to prescribe guideline-recommended treatments people with multimorbidity than a single condition. Doubts as the applicability of clinical trials drug (the gold standard for evidence-based medicine) when have co-existing diseases (comorbidity) may underlie this apparent reluctance. Therefore, range index conditions, we measured comorbidity among participants in novel therapies and compared patients community. Methods Data from industry-sponsored...
Abstract Identifying mechanisms underlying the intergenerational transmission of risk for attention-deficit/hyperactivity disorder (ADHD) traits can inform interventions and provide insights into role parents in shaping their children’s outcomes. We investigated whether genetic nurture (environmentally mediated effects) underlie associations between polygenic scores indexing parental protective factors offspring’s ADHD traits. This birth cohort study included 19,506 genotyped...
The aetiology of conduct problems involves a combination genetic and environmental factors, many which are inherently linked to parental characteristics given parents' central role in children's lives across development. It is important disentangle what extent links between heritable behaviour due transmission risk or indirect influences via the environment (i.e., nurture). We used 31,290 genotyped mother-father-child trios from Norwegian Mother, Father Child Cohort Study (MoBa), testing...
Abstract Background The timing of puberty may have an important impact on adolescent mental health. In particular, earlier age at menarche has been associated with elevated rates depression in adolescents. Previous research suggests that this relationship be causal, but replication and investigation whether effect extends to other health domains is warranted. Methods Registered Report, we triangulated evidence from different causal inference methods using a new wave data ( N = 13,398) the...
Abstract The major anxiety disorders (ANX; including generalized disorder, panic and phobias ) are highly prevalent, often onset early, persist throughout life, cause substantial global disability. Although distinct in their clinical presentations, they likely represent differential expressions of a dysregulated threat-response system. Here we present genome-wide association meta-analysis comprising 122,341 European ancestry ANX cases 729,881 controls. We identified 58 independent...
Datasets comprising twins and their children can be a useful tool for understanding the nature of intergenerational associations between parent offspring phenotypes. In present article we explore structural equation models previously used to analyse Children-of-Twins data, highlighting some limitations considerations. We then new variants these models, showing that extending include multiple per addresses several discussed. Accompanying updated provide power calculations demonstrate with...
Many studies detect associations between parent behaviour and child symptoms of anxiety depression. Despite knowledge that depression are influenced by a complex interplay genetic environmental risk factors, most do not account for shared familial risk. Quantitative designs provide means controlling genetics, but rely on observed putative exposure variables, require data from highly specific family structures.
Background Children in the UK go through rigorous teacher assessments and standardized exams throughout compulsory (elementary secondary) education, culminating with GCSE (General Certificate of Secondary Education) at age 16 A‐level (Advanced 18. These are a major tipping point directing young individuals towards different lifelong trajectories. However, little is known about associations between exam performance or how well these two measurement approaches predict educational outcomes end...
Background Neurodevelopmental conditions are highly heritable. Recent studies have shown that genomic heritability estimates can be confounded by genetic effects mediated via the environment (indirect effects). However, relative importance of direct versus indirect on early variability in traits related to neurodevelopmental is unknown. Methods The sample included up 24,692 parent‐offspring trios from Norwegian MoBa cohort. We use Trio‐GCTA estimate latent and mother‐reported at age 3 years...
Importance: The associations between eating disorder polygenic scores and disorders areunclear. Furthermore, while both genetic environmental factors contribute to thedevelopment of disorders, their interplay is poorly understood.Objective: This study extends prior research by examining whether childhood maltreatment andpolygenic for anorexia nervosa binge-eating are associated with disorders. Wealso examine the interactions geneticliability in predicting disorders.Design, Setting...
Abstract Childhood emotional and behavioural difficulties tend to co-occur often precede diagnosed neuropsychiatric conditions. Identifying shared specific risk factors for early-life mental health is therefore essential prevention strategies. Here, we examine how parental shape their offspring’s symptoms (e.g. feelings of anxiety, restlessness) using data from 14,959 genotyped family trios the Norwegian Mother, Father Child Cohort Study (MoBa). We model maternal reports symptoms, organizing...
It has been proposed that early risk constellations link differentially to later developmental outcomes. However, existing studies often use a limited set of indicators, excluding genetic and child-based risks. is also unclear if the protective effects potential moderators, such as kindergarten experiences, differ across groups. Using data from Norwegian Mother, Father Child (MoBa) cohort study (n = 7,478), we established latent classes based on family, child, factors measured up 3 years...