A5052366730- Health, Environment, Cognitive Aging
- Attention Deficit Hyperactivity Disorder
- Epilepsy research and treatment
- Child and Adolescent Psychosocial and Emotional Development
- Autism Spectrum Disorder Research
- Functional Brain Connectivity Studies
- Adolescent and Pediatric Healthcare
- Genomic variations and chromosomal abnormalities
- Genetics and Neurodevelopmental Disorders
- Genetic Associations and Epidemiology
- Pharmacological Effects and Toxicity Studies
- Cognitive Abilities and Testing
- Bipolar Disorder and Treatment
- Congenital heart defects research
- EEG and Brain-Computer Interfaces
- Ion Transport and Channel Regulation
- Health disparities and outcomes
- Early Childhood Education and Development
- Child Nutrition and Feeding Issues
- Veterinary Equine Medical Research
- Musculoskeletal pain and rehabilitation
- COVID-19 and Mental Health
- Infant Development and Preterm Care
- Genomics and Rare Diseases
- Veterinary Orthopedics and Neurology
Cardiff University
2023-2025
Genomics (United Kingdom)
2024
University of Connecticut
2024
University of Vermont
2024
University College London
2024
King's College London
2020-2023
Hartpury University
2020
Abstract Background The prevalence of youth anxiety and depression has increased globally, with limited causal explanations. Long-term physical health conditions (LTCs) affect 20–40% youth, rates also rising. LTCs are associated higher anxiety; however, it is uncertain whether observed associations or explained by unmeasured confounding reverse causation. Methods Using data from the Norwegian Mother, Father, Child Cohort Study (MoBa) National Patient Registry, we investigated phenotypic...
Abstract Juvenile myoclonic epilepsy (JME) is a common idiopathic generalised with variable seizure prognosis and sex differences in disease presentation. Here, we investigate the combined epidemiology of sex, types precipitants, their influence on JME, through cross-sectional data collected by The Biology Myoclonic Epilepsy (BIOJUME) consortium. 765 individuals met strict inclusion criteria for JME (female:male, 1.8:1). 59% females 50% males reported triggered seizures, only, this was...
Abstract Objective Impulsivity is a multidimensional construct that can predispose to psychopathology. Meta‐analysis demonstrates an association between response impulsivity and Juvenile Myoclonic Epilepsy (JME), common genetic generalized epilepsy. Here, we test the hypotheses trait (i) elevated in JME compared controls; (ii) moderated by specific seizure characteristics; (iii) associated with psychiatric adverse effects of antiepileptic drugs (AEDs). Methods 322 participants 126 age...
Attention Deficit Hyperactivity Disorder (ADHD) is associated with a range of adverse outcomes in adult life. However it unclear whether the risk pathways to are established during childhood or associations driven by concurrent ADHD symptoms that have persisted adulthood.
The COVID-19 pandemic negatively impacted mental health globally. Individuals with neurodevelopmental disorders (NDDs), including autism spectrum disorder (ASD) and attention deficit hyperactivity (ADHD), are at elevated risk of difficulties. We investigated the impact on anxiety, depression wellbeing in adults NDDs using data from Avon Longitudinal Study Parents Children (n = 3058). Mental were collected pre-pandemic (age 21-25) three timepoints during (ages 27-28) Short Mood Feelings...
Abstract Elevated impulsivity is a key component of attention-deficit hyperactivity disorder (ADHD), bipolar and juvenile myoclonic epilepsy (JME). We performed genome-wide association, colocalization, polygenic risk score, pathway analysis in JME ( n = 381). Results were followed up with functional characterisation using drosophila model. identified associated SNPs at 8q13.3 P 7.5 × 10 −9 ) 10p11.21 3.6 −8 ). The locus colocalizes SLCO5A1 expression quantitative trait loci cerebral cortex...
Background Attention deficit hyperactivity disorder (ADHD) and autism, defined as traits or disorders, commonly co‐occur. Developmental trajectories of ADHD autistic both show heterogeneity in onset course, but little is known about how symptom co‐develop into adulthood. Methods Using data from a population cohort, the Avon Longitudinal Study Parents Children, we examined correlations between across development, using Social Communication Disorders Checklist subscale Strengths Difficulties...
Abstract Emotional problems (anxiety, depression) are prevalent in children, adolescents and young adults with varying ages at onset. Studying developmental changes emotional requires repeated assessments using the same or equivalent measures. The parent-rated Strengths Difficulties Questionnaire is commonly used to assess childhood adolescence, but there limited research about whether it captures a similar construct across these periods. Our study addressed this by investigating measurement...
Anxiety and depression (emotional disorders) are familial heritable, especially when onset is early. However, other cross-generational studies suggest transmission of youth emotional problems explained by mainly environmental risks. We set out to test the contribution parental non-transmitted genetic liability, as indexed psychiatric/neurodevelopmental common polygenic using a UK population-based cohort: Millennium Cohort Study. European (N = 6328) South Asian 814) ancestries were included,...
Background Depression and anxiety are the most common mental health problems in young people. Currently, clinicians advised to wait before initiating treatment for people with these disorders as many spontaneously remit. However, others develop recurrent disorder but this subgroup cannot be identified at outset. We examined whether psychiatric polygenic scores (PGS) could help inform stratification efforts predict those higher risk of recurrence. Methods Probable emotional was two UK...
Irritability, defined as proneness to anger that may reach an impairing extent, is common in youth. There has been a recent upsurge relevant research. We combine systematic and narrative review approaches integrate the latest clinical translational findings provide suggestions address research gaps. Clinicians researchers should assess irritability routinely; specific assessment tools are now available. Informant effects prominent, stable, vary by age gender. The prevalence of particularly...
Dynamic mobilisation exercises (DME) are often used as part of a physiotherapy rehabilitation programme. Whilst immediate kinematic effects have been measured, the change in posture is anecdotally reported to longer duration. This study aimed test reliability simple objective measurement method, suitable for use clinical practice, and objectively measure equine thoracolumbar posture, before after DME. A single investigator took triplicate measurements sagittal shape using flexicurve ruler...
Abstract Anxiety and depression (emotional disorders) are familial heritable, especially when onset is early. However, other cross-generational studies suggest transmission of youth emotional problems explained by mainly environmental risks. We set out to test the contribution parental non-transmitted genetic liability, as indexed psychiatric/neurodevelopmental common polygenic using a UK population-based cohort: Millennium Cohort Study. European (N=6,328) South Asian (N=814) ancestries were...
Objective: Neurocognitive impairments are associated with child and adult ADHD in clinical settings. However, it is unknown whether symptoms the general population same pattern of cognitive impairment. We examined this using a prospective, population-based cohort spanning birth to age 25 years. Methods: associations between self-reported task performance (attention response inhibition) adulthood childhood. Results: Self-rated at were poorer tasks capturing ADHD-related functioning B = −0.03,...
Abnormal EEG features are a hallmark of epilepsy, and abnormal frequency network apparent in EEGs from people with idiopathic generalized epilepsy both ictal interictal states. Here, we characterize differences the resting-state individuals juvenile myoclonic assess factors influencing heterogeneity features. We collected data 147 participants through Biology Juvenile Myoclonic Epilepsy study. Ninety-five control were acquired two independent studies [Chowdhury et al. (2014) EU-AIMS...
Abstract Abnormal EEG features are a hallmark of epilepsy, and abnormal frequency network apparent in EEGs from people with idiopathic generalised epilepsy both ictal interictal states. Here, we characterise differences the resting-state individuals juvenile myoclonic (JME) assess factors influencing heterogeneity these features. We collected data 147 participants JME through Biology Juvenile Myoclonic Epilepsy (BIOJUME) study. 95 control were acquired two independent studies (Chowdhury et...
Abstract The COVID-19 pandemic negatively impacted mental health globally. Individuals with neurodevelopmental disorders (NDDs), including autism spectrum disorder (ASD) and attention deficit hyperactivity (ADHD), are at elevated risk of difficulties. Therefore, we investigated the impact on anxiety, depression wellbeing in adults NDDs using longitudinal data from Avon Longitudinal Study Parents Children study (n=3,058). Mental were collected pre-pandemic (age 21-25) three timepoints during...
Introductory Paragraph Elevated impulsivity is a key component of attention-deficit hyperactivity disorder (ADHD), bipolar and epilepsy 1-5 . We performed genome-wide association, colocalization pathway analysis in juvenile myoclonic (JME). identify associated SNPs at 8q13.3 (p=7.5 × 10 −9 ) 10p11.21 (p=3.6 −8 ). The locus colocalizes with SLCO5A1 expression quantitative trait loci cerebral cortex (p=9.5 −3 codes for membrane-bound organic anion transporter 6 upregulates synapse...