A5045545614- Neurogenesis and neuroplasticity mechanisms
- Alzheimer's disease research and treatments
- Diet and metabolism studies
- Cancer-related cognitive impairment studies
- Genetics, Aging, and Longevity in Model Organisms
- Tryptophan and brain disorders
- Neuroscience and Neuropharmacology Research
- Sirtuins and Resveratrol in Medicine
- MicroRNA in disease regulation
- Spaceflight effects on biology
- Stress Responses and Cortisol
- Neuroinflammation and Neurodegeneration Mechanisms
- FOXO transcription factor regulation
- Planarian Biology and Electrostimulation
- Bioinformatics and Genomic Networks
- Anesthesia and Neurotoxicity Research
- Dietary Effects on Health
- Adipose Tissue and Metabolism
- Polyamine Metabolism and Applications
- Biochemical effects in animals
- Amino Acid Enzymes and Metabolism
- Nuclear Receptors and Signaling
- Axon Guidance and Neuronal Signaling
King's College London
2013-2023
Hammersmith Hospital
2013
Imperial College London
2013
Abstract Daily calorie restriction (CR) and intermittent fasting (IF) enhance longevity cognition but the effects mechanisms that differentiate these two paradigms are unknown. We examined whether IF in form of every-other-day feeding enhances adult hippocampal neurogenesis (AHN) when compared to a matched 10% daily CR intake ad libitum conditions. After 3 months under IF, female C57BL6 mice exhibited improved long-term memory retention. increased number BrdU-labeled cells neuroblasts...
Abstract Adult hippocampal neurogenesis is important for learning and memory altered early in Alzheimer’s disease. As modulated by the circulatory systemic environment, evaluating a proxy of how affected milieu could serve as an biomarker disease progression. Here, we used vitro assay to model impact environment on neurogenesis. A human progenitor cell line was treated with longitudinal serum samples from individuals mild cognitive impairment, who either progressed or remained cognitively...
Abstract Aging induces cellular and molecular changes including modification of stem cell pools. In particular, alterations in aging neural cells (NSCs) are linked to age-related cognitive decline which can be modulated by lifestyle. Nutrient-sensing pathways provide a basis for the link between lifestyle decline. Adopting back-translation strategy using biology inform epidemiological analyses, here we show associations readouts NSC maintenance expression levels nutrient-sensing genes...
Age-related alteration in neural stem cell function is linked to neurodegenerative conditions and cognitive decline. In rodents, this can be reversed by exposure a young systemic milieu conversely, the old inhibit rodents. study, we investigated
Antidepressant‐induced hippocampal neurogenesis (AHN) is hypothesized to contribute increases in volume among major depressive disorder patients after long‐term treatment. Furthermore, rodent studies suggest AHN may be the cellular mechanism mediating therapeutic benefits of antidepressants. Here, we perform first investigation genome‐wide expression changes associated with human cells. We identify gene networks significantly activated during AHN, and set analyses probe molecular...
Hippocampal volumes are smaller in psychiatric disorder patients and lower levels of hippocampal neurogenesis the hypothesized cause. Understanding which molecular processes regulate progenitor differentiation might aid identification novel drug targets that can promote larger volumes. Here we use a unique human cell line to assay genome-wide expression changes when cells differentiate. RNA was extracted from proliferating versus differentiated neural applied Illumina Human HT-12 v4...
Current pharmacological treatments for major depressive disorder (MDD) are ineffective in a significant proportion of patients, and the identification new antidepressant compounds has been difficult. ‘Connectivity mapping’ is method that can be used to identify drugs elicit similar downstream effects on mRNA levels when compared current treatments, thus may point towards possible repositioning opportunities. We investigated genome-wide transcriptomic changes human hippocampal progenitor...
Abstract The generation of new neurons persists into adulthood in the human hippocampus and can be modulated by circulatory systemic environment. Hippocampal neurogenesis is important for learning memory altered Alzheimer’s Disease (AD). Evaluating hippocampal neurogenic process during disease progression could therefore identify as an target AD prevention intervention well a biomarker early detection. In this study, we used progenitor cell line to design vitro assay evaluating over time...
The generation of neurons persists into adulthood in the human hippocampus and is modulated by circulatory systemic environment. Hippocampal neurogenesis important for learning memory altered early Alzheimer’s Disease (AD). Evaluating hippocampal neurogenic processes during AD progression could therefore be a biomarker disease detection. Here, we used progenitor cell line to evaluate vitro over time impact milieu (i.e. serum) individuals with mild cognitive impairment (MCI) as they either...