A5048278412- Amyotrophic Lateral Sclerosis Research
- Genetic Neurodegenerative Diseases
- Parkinson's Disease Mechanisms and Treatments
- Alzheimer's disease research and treatments
- MicroRNA in disease regulation
- Endoplasmic Reticulum Stress and Disease
- Mitochondrial Function and Pathology
- Anesthesia and Neurotoxicity Research
- Mental Health and Patient Involvement
- Advanced Neuroimaging Techniques and Applications
- Biomedical Ethics and Regulation
- Dementia and Cognitive Impairment Research
- Community Health and Development
- Homelessness and Social Issues
- Neurogenetic and Muscular Disorders Research
- Neurogenesis and neuroplasticity mechanisms
- Signaling Pathways in Disease
- ATP Synthase and ATPases Research
- Memory and Neural Mechanisms
University of Sheffield
2023
King's College London
2018-2022
Eisai (United Kingdom)
2016
Signaling between the endoplasmic reticulum (ER) and mitochondria regulates a number of key neuronal functions, many which are perturbed in Alzheimer's disease. Moreover, damage to ER-mitochondria signaling is seen cell transgenic models However, as yet there little evidence that altered human disease brains. mediated by interactions integral ER protein VAPB outer mitochondrial membrane PTPIP51 act recruit "tether" regions surface. The VAPB-PTPIP51 tethers now known regulate functions...
Signaling between the endoplasmic reticulum (ER) and mitochondria regulates many neuronal functions that are perturbed in amyotrophic lateral sclerosis (ALS) perturbation to ER-mitochondria signaling is seen cell transgenic models of ALS. However, there currently little evidence altered human mediated by interactions integral ER protein VAPB outer mitochondrial membrane PTPIP51 which act recruit “tether” regions surface. The VAPB-PTPI51 tethers now known regulate a number functions. These...
Individual differences in memory during ageing are associated with the microstructure of fornix, a bidirectional tract connecting hippocampus diencephalon, basal forebrain and cortex. To investigate origin alterations fornix microstructure, measurement hippocampal subfield volumes was combined diffusion MRI cognitive evaluation new sample 31 healthy human participants aged 50-89 years. The uncinate parahippocampal cingulum were reconstructed using tractography. Episodic assessed free cued...
Abstract Growing evidence suggests persistent mitochondrial permeability transition pore (mPTP) opening is a key pathophysiological event in cell death underlying variety of diseases. While it has long been clear the mPTP druggable target, current agents are limited by off-target effects and low therapeutic efficacy. Therefore identification development novel inhibitors necessary. To rapidly screen large compound libraries for modulators, method was exploited to cryopreserve batches...
Age-related alteration in neural stem cell function is linked to neurodegenerative conditions and cognitive decline. In rodents, this can be reversed by exposure a young systemic milieu conversely, the old inhibit rodents. study, we investigated
This exploratory study sought to understand the role of Mutual Aid groups during Covid-19 crisis. Group members were approached through convenience sampling across London and Leicester. Fifteen interviews took place from June August 2020. Data analysed using Thematic Analysis. Groups based on solidarity not charity. Most delimited by geographic ward provided rapid support neighbours with urgent material health needs, primarily food support, collecting medical prescriptions providing...