A5042126243- Neuroscience and Neuropharmacology Research
- Fungal Infections and Studies
- Parkinson's Disease Mechanisms and Treatments
- Antifungal resistance and susceptibility
- Cellular transport and secretion
- Neurogenetic and Muscular Disorders Research
- Pneumocystis jirovecii pneumonia detection and treatment
- Alzheimer's disease research and treatments
- Autophagy in Disease and Therapy
- Neurotransmitter Receptor Influence on Behavior
- Biomedical Ethics and Regulation
- Lysosomal Storage Disorders Research
- Mitochondrial Function and Pathology
- Genetic Neurodegenerative Diseases
- Amyotrophic Lateral Sclerosis Research
- Receptor Mechanisms and Signaling
- Neutropenia and Cancer Infections
University of Sheffield
2019-2024
Memorial Sloan Kettering Cancer Center
2017-2020
The Ohio State University
2007-2008
It is important to understand how the disease process affects metabolic pathways in amyotrophic lateral sclerosis and whether these can be manipulated ameliorate progression. To analyse basis of defect we used a phenotypic profiling approach. Using fibroblasts reprogrammed induced astrocytes from C9orf72 sporadic cases measured production rate reduced nicotinamide adenine dinucleotides (NADH) 91 potential energy substrates simultaneously. Our screening approach identified that have distinct...
We sought to describe the clinical experience of voriconazole as primary antifungal prophylaxis (AFP) in allogeneic hematopoietic cell transplant recipients (allo-HCTr). This was a single-center retrospective study adult allo-HCTr (1 January 2014 31 December 2016) who received ≥two doses voriconazole-AFP. Voriconazole-AFP started on day +7 post-HCT and continued at least through +60 post-HCT, or longer clinically indicated. reviewed rate, reasons, risk factors voriconazole-AFP...
Abstract Results from several experiments monitoring extracellular dopamine (DA) after stimulating axons at high frequencies have been interpreted as evidence for release two populations of vesicles in dopaminergic varicosities. In addition, these suggested that cocaine and other transporter (DAT) inhibitors promote transfer or itself a reserve pool to readily available pool. We developed computer model simulation with the goal determining set mathematical formulas describe movement between...
Abstract Background High rates of discontinuation voriconazole (VCZ) antifungal prophylaxis (AFP) due to toxicities have been reported from single centers in allogeneic hematopoietic (allo-HCT) recipients. We sought describe (i) adherence AFP guidelines and (ii) reasons for premature VCZ (D/C). Methods Retrospective review 215 adult allo-HCT recipients September 1, 2014–December 31, 2015 at our center. Per standards care (SOC), patients received micafungin Day 2 post-allo-HCT, then switched...
Results from several different experimental paradigms have been interpreted as supporting the concept that two populations of dopamine storage vesicles exist in nerve terminals dopaminergic neurons. The goal this work is to develop a computer simulation model varicosity provides plausible quantitative description these and possible set rules for movement between vesicles. We first looked at how well one compartment accurate simulations published data. allocates among three compartments:...