A5030724805- Mitochondrial Function and Pathology
- Nematode management and characterization studies
- ATP Synthase and ATPases Research
- Entomopathogenic Microorganisms in Pest Control
- Parasite Biology and Host Interactions
- Alzheimer's disease research and treatments
- Cassava research and cyanide
- Coenzyme Q10 studies and effects
- RNA modifications and cancer
- Viral Infectious Diseases and Gene Expression in Insects
- RNA regulation and disease
- Redox biology and oxidative stress
- Neuroscience and Neuropharmacology Research
- Legume Nitrogen Fixing Symbiosis
- Endoplasmic Reticulum Stress and Disease
- Biochemical Acid Research Studies
- Insect Resistance and Genetics
University of Sheffield
2023-2024
University of Bari Aldo Moro
2021-2023
Institute for Sustainable Plant Protection
2017-2018
In mammalian mitochondria, the processing of primary RNA transcripts involves a coordinated series cleavage and modification events, leading to formation intermediates mature mt-RNAs. RNA19 is an unusually stable unprocessed precursor, physiologically polyadenylated, which includes 16S mt-rRNA, mt-tRNALeuUUR mt-ND1 mRNA. These peculiarities, together with alteration its steady-state levels in cellular models defects mitochondrial function, make potentially important molecule for...
The m.3243A>G mutation within the mitochondrial mt-tRNALeu(UUR) gene is most prevalent variant linked to encephalopathy with lactic acidosis and stroke-like episodes (MELAS) syndrome. This pathogenic causes severe impairment of protein synthesis due alterations mutated tRNA, such as reduced aminoacylation a lack post-transcriptional modification. In transmitochondrial cybrids, overexpression human leucyl-tRNA synthetase (LARS2) has proven effective in rescuing phenotype associated...
Mitochondria are involved in many dynamic processes, including their role the production of cell's energy currency, adenosine triphosphate (ATP).This is carried out through a complex chain chemical reactions, followed by transition electrons four protein clusters on mitochondrial membrane called respiratory complexes.This transfer drives protons across creating high concentration one side membrane.The difference concentration, known as potential (MMP), allows flow Complex V to combine...