A5060110410- Particle physics theoretical and experimental studies
- High-Energy Particle Collisions Research
- Quantum Chromodynamics and Particle Interactions
- Particle Detector Development and Performance
- Dementia and Cognitive Impairment Research
- Dark Matter and Cosmic Phenomena
- Functional Brain Connectivity Studies
- EEG and Brain-Computer Interfaces
- Cosmology and Gravitation Theories
- Neurobiology of Language and Bilingualism
- Neural dynamics and brain function
- Alzheimer's disease research and treatments
- Labor Movements and Unions
- Emotion and Mood Recognition
- Acute Ischemic Stroke Management
- Computational Physics and Python Applications
- Amyotrophic Lateral Sclerosis Research
- Interpreting and Communication in Healthcare
- Neutrino Physics Research
- Language Development and Disorders
- Language, Discourse, Communication Strategies
- Black Holes and Theoretical Physics
- Psychosomatic Disorders and Their Treatments
- Speech Recognition and Synthesis
- Mitochondrial Function and Pathology
University of Sheffield
2016-2025
Royal Hallamshire Hospital
2014-2025
Sheffield Teaching Hospitals NHS Foundation Trust
2014-2024
Saskatoon Medical Imaging
2024
United Kingdom Atomic Energy Authority
2023
Culham Science Centre
2023
University of Washington
2013-2022
Seattle University
2013-2022
Brunel University of London
2022
Devices for Dignity
2022
Dissociative seizures are paroxysmal events resembling epilepsy or syncope with characteristic features that allow them to be distinguished from other medical conditions. We aimed compare the effectiveness of cognitive behavioural therapy (CBT) plus standardised care alone for reduction dissociative seizure frequency.In this pragmatic, parallel-arm, multicentre randomised controlled trial, we initially recruited participants at 27 neurology services in England, Scotland, and Wales. Adults...
Tau plays a key role in Alzheimer's disease (AD) pathophysiology, and accumulating evidence suggests that lowering tau may reduce this pathology. We sought to inhibit MAPT expression with tau-targeting antisense oligonucleotide (MAPT
Objectives: In the UK dementia is under-diagnosed, there limited access to specialist memory clinics, and many of patients referred such clinics are ultimately found have functional (non-progressive) disorders (FMD), rather than a neurodegenerative disorder. Government initiatives on 'timely diagnosis' aim improve rate quality diagnosis for those with dementia. This study seeks screening diagnostic process by analysing communication between clinicians during initial clinic visits....
Alzheimer's disease (AD) accounts for 60%-70% of all dementia cases, and clinical diagnosis at its early stage is extremely difficult. As several new drugs aiming to modify progression or alleviate symptoms are being developed, assess their efficacy, novel robust biomarkers brain function urgently required. This paper aims explore a routine gain such using the quantitative analysis electroencephalography (QEEG). proposes supervised classification framework that uses EEG signals classify...
Alzheimer's disease (AD) is the leading form of dementia worldwide. AD disrupts neuronal pathways and thus commonly viewed as a network disorder. Many studies demonstrate power functional connectivity (FC) graph-based biomarkers for automated diagnosis using electroencephalography (EEG). However, various FC measures are utilised, each aims to quantify unique aspect brain coupling. Graph neural networks (GNN) provide powerful framework learning on graphs. While growing number use GNN classify...
Background: current literature suggests that two-thirds of patients will have cognitive impairment at 3 months post-stroke. Post-stroke is associated with impaired function and increased mortality. UK guidelines recommend all stroke a assessment within 6 weeks. There no ‘gold standard’ screening tool. The Montreal (MoCA) more sensitive than the Mini-Mental State Examination (MMSE) in mild for non-acute post-stroke setting Chinese-speaking acute setting. Methods: convenience sample 50...
Background Stroke is associated with the development of cognitive impairment and dementia. We assessed effect intensive blood pressure (BP) and/or lipid lowering on outcomes in patients recent stroke a pilot trial. Methods In multicentre, partial-factorial trial, stroke, absence dementia, systolic BP (SBP) 125–170 mmHg were assigned randomly to at least 6 months (target SBP <125 mmHg) or guideline <140 lowering. The subset ischaemic total cholesterol 3.0–8.0 mmol/l also LDL-cholesterol <1.3...
Alzheimer's disease (AD) is the leading cause of dementia worldwide. Mitochondrial abnormalities have been identified in many cell types AD, with deficits preceding development classical pathological aggregations. Ursodeoxycholic acid (UDCA), a treatment for primary biliary cirrhosis, improves mitochondrial function fibroblasts derived from Parkinson's patients as well several animal models AD and disease. In this paper, we investigated both morphology sporadic familial AD. We show that...
Background: The early diagnosis of dementia is great clinical and social importance. A recent study using the qualitative methodology conversation analysis (CA) demonstrated that language communication problems are evident during interactions between patients neurologists, interactional observations can be used to differentiate cognitive difficulties due neurodegenerative disorders (ND) or functional memory (FMD). Objective: This explores whether differential diagnostic doctor-patient in a...
The early signs of cognitive decline are often noticeable in conversational speech, and identifying those is crucial dealing with later more serious stages neurodegenerative diseases. Clinical detection costly time-consuming although there has been recent progress the automatic speech-based cues, systems trained on relatively small databases, lacking detailed metadata demographic information. This paper presents CognoSpeak its associated data collection efforts. asks memory-probing long...
Background: The incidence of Alzheimer disease (AD) is increasing with the ageing population. development low cost non-invasive diagnostic aids for AD a research priority. This pilot study investigated whether an approach based on novel dynamic quantitative parametric EEG method could detect abnormalities in people AD. Methods: 20 patients probable AD, matched healthy controls (HC) and 4 fronto temporal dementia (FTD) were included. All had detailed neuropsychology along structural, resting...