A5049534732- Advanced Radiotherapy Techniques
- Glioma Diagnosis and Treatment
- Dementia and Cognitive Impairment Research
- Radiation Therapy and Dosimetry
- Brain Metastases and Treatment
- Lung Cancer Diagnosis and Treatment
- Alzheimer's disease research and treatments
- Radiomics and Machine Learning in Medical Imaging
- Effects of Radiation Exposure
- Spinal Fractures and Fixation Techniques
- Radiation Dose and Imaging
- Cholinesterase and Neurodegenerative Diseases
- Ultrasound and Hyperthermia Applications
- Venous Thromboembolism Diagnosis and Management
- Advances in Oncology and Radiotherapy
- Health, Environment, Cognitive Aging
- Lung Cancer Research Studies
- Medical Imaging Techniques and Applications
- Lung Cancer Treatments and Mutations
- Management of metastatic bone disease
- Blood Pressure and Hypertension Studies
- Meningioma and schwannoma management
- Spine and Intervertebral Disc Pathology
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Trauma and Emergency Care Studies
Johns Hopkins University
2016-2025
Johns Hopkins Hospital
2019-2024
Sidney Kimmel Comprehensive Cancer Center
2023
Biogen (United States)
2017-2023
Johns Hopkins Medicine
2016-2022
St. George's University
2022
Rangsit University
2022
Aga Khan University Hospital
2022
Indus Hospital
2022
Walailak University
2022
Tau plays a key role in Alzheimer's disease (AD) pathophysiology, and accumulating evidence suggests that lowering tau may reduce this pathology. We sought to inhibit MAPT expression with tau-targeting antisense oligonucleotide (MAPT
Purpose. To investigate the potential role of incidental heart irradiation on risk radiation pneumonitis (RP) for patients receiving definitive therapy non-small-cell lung cancer (NSCLC). Material and methods. Two hundred nine patient datasets were available this study. Heart dose-volume parameters extracted modeling, based Monte Carlo-based heterogeneity corrected dose distributions. Clinical variables tested included age, gender, chemotherapy, pre-treatment weight-loss, performance status,...
Background. Tumor control probability (TCP) to radiotherapy is determined by complex interactions between tumor biology, microenvironment, radiation dosimetry, and patient-related variables. The complexity of these heterogeneous variable constitutes a challenge for building predictive models routine clinical practice. We describe datamining framework that can unravel the higher order relationships among dosimetric dose-volume prognostic variables, interrogate various radiobiological...
Abstract Background The optimal regimen, normal tissue tolerances, and appropriate indications for reirradiation recurrent high-grade glioma (HGG) are uncertain. aim of this study was to determine whether higher dose associated with toxicity or survival. Methods Patients HGG treated fractionated at a single institution from 2007 2022 were retrospectively reviewed. Metrics evaluated included overall survival (OS), prognostic factors survival, treatment-related toxicity. Results Two hundred...
Improvements in systemic therapy continue to increase survival for patients with brain metastases. Updated dosimetric models are required optimize long-term safety of stereotactic radiosurgery (SRS) this indication.Patients at a single institution receiving SRS from December 2011 2014 were retrospectively reviewed. Patients radiographic progression least one lesion, and 6 months follow-up the start included. Grade 3 necrosis was defined as requiring surgical intervention. This data combined...
Abstract Purpose A single treatment planning system (TPS) model for matched linacs provides flexible clinical workflows from patient to intensity‐modulated radiation therapy (IMRT) quality assurance (QA) measurement. Since general guidelines building a TPS and its validation are not well established, we present our RayStation photon modeling strategy Elekta VersaHD linacs. Method The four installed 2013 2020 were in terms of Percent Depth Dose (PDD), profile, output factor wedge factors...
To inform development of procedures for using tumor-treating field arrays (TTFields) during glioblastoma radiation therapy by determining whether the placement and repositioning affects target volume coverage cranial skin dose.Radiation plans from 10 consecutive patients treated were copied to a phantom reoptimized anatomy. Dose distributions then recalculated on 3 additional computed tomographic scans with TTFields electrode placed over distinct locations scalp compare planning (PTV) dose...
Treatment planning factors are known to affect the risk of severe acute esophagitis during thoracic radiation therapy. We tested a previously published model predict on an independent data set.The set consists from patients who had recoverable treatment plans and received definitive therapy for non-small cell carcinoma lung at single institution between November 2004 January 2010. Complete esophagus dose-volume available clinical information was extracted using our in-house software. The...
The purpose of this study was to evaluate the utility routine anti-Xa peak monitoring for trauma patients initiated on weight-based enoxaparin venous thromboembolism (VTE) prophylaxis and identify patient populations where is necessary.Retrospective study.Augusta University (AU) Medical Center in Augusta, Georgia, a level 1 center.Adult admitted surgery service requiring chemical VTE prophylaxis.At least three consecutive doses 0.5 mg/kg subcutaneously every 12 hour prior an as initial...
Abstract Background ISIS 814907 (BIIB080) is an antisense oligonucleotide (ASO) that hybridizes to a complementary nucleotide sequence of mRNA the human microtubule‐associated protein tau ( MAPT ) gene, preventing production protein. Accumulation hyperphosphorylated associated with cognitive decline and brain atrophy in Alzheimer’s Disease (AD). The placebo controlled period Phase 1b multiple ascending dose (MAD) study patients mild AD complete open‐label long term extension (LTE) ongoing...
One of the most persistent health disparities is underutilization mental services by people color. Neither evidence-based treatments (universal focus), nor culturally-adapted (group have reduced these disparities. We propose Personal Relevance Psychotherapy (PROP) model that integrates universal, group, and individual dimensions to determine personal relevance interventions. A cultural example among East Asian ancestry involves “face” (i.e., one’s prestige position in society) which may...