A5028606825- Glioma Diagnosis and Treatment
- Brain Metastases and Treatment
- Advanced Radiotherapy Techniques
- Immune cells in cancer
- Management of metastatic bone disease
- Visual perception and processing mechanisms
- Head and Neck Cancer Studies
- Sympathectomy and Hyperhidrosis Treatments
- Radiation Therapy and Dosimetry
- Cancer Immunotherapy and Biomarkers
- Neuroinflammation and Neurodegeneration Mechanisms
- Breast Cancer Treatment Studies
- Neurofibromatosis and Schwannoma Cases
- Cancer Diagnosis and Treatment
- Diabetes Treatment and Management
- Cancer Cells and Metastasis
- Lung Cancer Research Studies
- Meningioma and schwannoma management
- Color perception and design
- Head and Neck Surgical Oncology
- Glaucoma and retinal disorders
- Radiation Effects and Dosimetry
- Inflammatory Biomarkers in Disease Prognosis
- Monoclonal and Polyclonal Antibodies Research
- Tracheal and airway disorders
University of Minnesota Medical Center
2022-2025
Johns Hopkins Medicine
2017-2024
Johns Hopkins University
1934-2024
Sidney Kimmel Comprehensive Cancer Center
2019-2024
Bloomberg (United States)
2019-2024
University of Minnesota
2021-2024
University of Oxford
2023
North Memorial Health Care
2021
Johns Hopkins Hospital
2018
University of Pennsylvania
2016
In a former paper two of the present writers described methods for increasing diagnostic sensitivity perimetry with form field stimulus. It was pointed out that should be especially effective and feasible in branch study is commonly called scotometry. our purpose to show what success may used early detection Bjerrum other scotomas. practice scotometry stimulus, means are comparatively obvious. order pick up faint or incipient scotomas, it necessary only decrease by sufficient amount...
Glioblastoma (GB) is a primary brain tumor that lethal and challenging to treat. The 3-year overall survival (OS) of patients with this diagnosis has stayed the same since 2005. patient 75-year-old woman who presented progressive aphasia was diagnosed GB (WHO grade 4, IDH1/IDH2 wild type, ATRX intact, p53 PTEN mutant, BRAF non-mutated, O 6 -methylguanine-DNA methyltransferase promoter methylated) underwent surgical resection, hypofractionated radiotherapy (HFRT) using intensity-modulated...
INTRODUCTION: Determining true recurrence versus necrosis alone after previous radiotherapy (RT) for brain metastasis based on imaging is challenging. Accurate diagnosis critical to patient management, as further RT contraindicated in the setting of radiation without tumor (TUM-). METHODS: Rates intraoperative frozen section pathology reporting +/- (TUM+) or (TUM-) were examined patients undergoing resection presumed RBM prior same-site RT. All cases prospectively enrolled a...
Since the classical work of Wertheim<sup>1</sup>there have been many studies peripheral visual acuity. Those published prior to 1951 were thoroughly reviewed by Low.<sup>2</sup>Data from representative investigations are shown in Fig 1. Only two provide any information as variability normal acuity at each eccentric location. Low's paper<sup>3</sup>on 100 subjects gives data only for far periphery, 30°, 60°, and 90° fixation. Weymouth<sup>4</sup>published values mean threshold angle its...
A study of syphilitic optic neuropathies was undertaken in 1931 jointly by the division syphilology medical clinic and department ophthalmology Johns Hopkins Hospital University. This investigation included repeated special clinical ophthalmologic studies on a large group patients over period years, perimetric determinations light sense, comparison effects various types treatment primary atrophy nerve. There are available for correlation, therefore, accurate records data visual fields number...
An apparatus for testing both the light minimum and difference in dark adaptation use of this early diagnosis glaucoma have been described previous publications by Bovie;<sup>1</sup>by Waite, one us (G. S. D.) Kirk,<sup>2</sup>and two D. P. A. C.) O'Brien.<sup>3</sup>In last series papers, it was shown that a test is greater value than difference. Since, therefore, only need be tested, becomes possible to devise an instrument simpler construction previously described, which may used ordinary...
SEVERAL previous investigations * have compared tests purporting to measure the efficiency of binocular depth perception and attempted by statistical procedures, i.e., techniques correlation and, in some cases, factor analysis, determine extent which scores agree with one another measuring individual differences perception. In general these studies shown poor agreement measures provided different tests, especially when subjects subnormal visual acuity were excluded. From a consideration many...
In pigmentary degeneration of the retina, first symptom noticed by patient is as a rule disturbance vision in dim light. This suggests that some form test light sense could be used to detect incipient stages disease, prior appearance changes fundus, diminution visual acuity or alterations fields. A definite diagnosis its might help determining efficacy possible therapeutic measures. Many remedies have been tried, with reports moderate success investigators and complete failure...
One cannot fully test the soundness of ice on a skating pond or river by applying pressure at one spot. Similarly we know fundamental condition retina and sensorium as whole our tests only very few points in visual field. In preliminary studies, least, broad survey must be made for various types disease to find characteristic localities disturbance. When these are known, procedure used routine examination can, it is hoped, greatly simplified. determination limits sensitivity, example, ways...
Click to increase image sizeClick decrease size Résumé Dans cette étude on a fait une détermination de l'effet la grandeur prunelle sur les champs forme et couleur. On deux divisions l'étude,—l'une yeux non pathologiques, l'autre pathologiques. cet article ne donne que Les stimuli employés ont été d'un degré 0,17 blanc noir couleur rouge bleu des fonds gris clarté couleurs. obtenu résultats pour huit observateurs pathologiques: 3 myopes, hyperopes 2 emmetropes. décrit possibilités présentées...
This paper presents data on the scotomas found to be typical of incipient glaucoma. A study characteristics first perimetric symptoms glaucoma should furnish information value in making an early diagnosis. In this investigation it was that stages its development, arcuate scotoma known as Bjerrum sign frequently occurs isolated blind area not connected with normal spot. When no absolute could detected, often possible map which test object visible but appeared dimmer or darker than surrounding...
Calcitonin gene-related peptide (CGRP) is a neuropeptide that released at the neuromuscular junction in response to nerve excitation. To examine relationship between plasma CGRP concentration and intracellular glucose metabolism conscious rats, we performed insulin (22 pmol.kg-1.min-1) clamp studies combined with infusion of 0, 20, 50, 100, 200, 500 pmol.kg-1.min-1 (plasma concentrations ranging from 2 x 10(-11) 5 10(-9) M). antagonized insulin's suppression hepatic production (approximately...
Improvements in systemic therapy continue to increase survival for patients with brain metastases. Updated dosimetric models are required optimize long-term safety of stereotactic radiosurgery (SRS) this indication.Patients at a single institution receiving SRS from December 2011 2014 were retrospectively reviewed. Patients radiographic progression least one lesion, and 6 months follow-up the start included. Grade 3 necrosis was defined as requiring surgical intervention. This data combined...
Operative intervention by resection of the cervical sympathetic chain has been advocated as a therapeutic procedure for pigmentary degeneration retina. However, it regarded ophthalmologists with great deal skepticism. It is impossible to evaluate finality worth such procedures until more case reports are available. remarkable that there relatively so few in literature after brilliant successes recorded Royle.<sup>1</sup>Royle introduced his operation ramisection belief vascular disease...
The perimeter is designed especially for the determination of limits sensitivity in peripheral field vision ; tangent screen, more detailed studies needed central and paracentral portions field. two instruments are supplementary or less mutually exclusive. cannot be determined on a search conveniently made perimeter. Obviously both to complete diagnostic picture. To get consistent results with both, however, they should used under same set test conditions. That is, objects employed must have...
Glioblastoma recurrence between initial resection and standard-of-care adjuvant chemoradiotherapy (CRT) is a negative prognostic factor in an already highly aggressive disease. Re-resection with GammaTileⓇ(GT Medical Technologies Inc., Tempe, AZ) placement affords expedited radiation to mitigate the likelihood of such growth. Here, we report glioblastoma patient who underwent re-resection GammaTileⓇ (GT) within two months gross total due regrowth that reached size original presenting tumor....
The Bone Metastases Ensemble Trees for Survival Decision Support Platform (BMETS-DSP) provides patient-specific survival predictions and evidence-based recommendations to guide multidisciplinary management symptomatic bone metastases. We assessed the clinical utility of BMETS-DSP through a pilot prepost design in simulated environment.
Abstract PURPOSE/OBJECTIVE(S) Determining true recurrence versus necrosis alone after previous radiation therapy (RT) for brain metastasis based on imaging is difficult. Proper diagnosis essential, as further contraindicated in the setting of without tumor (TUM-). To better understand rate pathologic positivity (TUM+) vs TUM-, we examined frozen section results from a cohort patients with prior same-site RT undergoing resection presumed recurrent (RBM). MATERIALS/METHODS Rates intraoperative...