A5064425370- Glioma Diagnosis and Treatment
- MicroRNA in disease regulation
- Circular RNAs in diseases
- RNA Research and Splicing
- Chromatin Remodeling and Cancer
- Meningioma and schwannoma management
- Neuroscience and Neuropharmacology Research
- Neuroblastoma Research and Treatments
- Cancer-related molecular mechanisms research
- Cancer, Hypoxia, and Metabolism
- Brain Metastases and Treatment
- Extracellular vesicles in disease
- Radiomics and Machine Learning in Medical Imaging
- RNA modifications and cancer
- Cancer Cells and Metastasis
- 3D Printing in Biomedical Research
- Genetic Neurodegenerative Diseases
- Neurogenetic and Muscular Disorders Research
- Sarcoma Diagnosis and Treatment
- Nanoparticle-Based Drug Delivery
- Hippo pathway signaling and YAP/TAZ
- Epilepsy research and treatment
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- interferon and immune responses
University of Maryland, Baltimore
2018-2022
University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center
2019-2022
Johns Hopkins Medicine
2016-2019
Johns Hopkins University
2014-2019
Johns Hopkins Hospital
2015-2019
University of Baltimore
2019
Kennedy Krieger Institute
2018
Sidney Kimmel Comprehensive Cancer Center
2017
University of Michigan
2009-2013
McLean Hospital
2007
Cellular senescence and the senescence-associated secretory phenotype (SASP) may contribute to development of radiation therapy–associated side effects in lung blood vessels by promoting chronic inflammation. In brain, inflammation contributes neurologic disease, including Alzheimer's disease. this study, we investigated roles cellular Δ133p53, an inhibitory isoform p53, radiation-induced brain injury. Senescent cell types irradiated human were identified with immunohistochemical labeling...
H3 K27 mutations, most commonly in H3F3A, are common diffuse midline glioma. The exact frequency of these mutations adults with gliomas the location is unknown. This study was conducted to define incidence K27M this and compare clinicopathological features those patients who do not harbor mutation. Consecutive glioma cases from 2007 2017 were screened for location. Immunohistochemistry performed on all available tissue K27M, IDH1, ARTX. Of 850 screened, 163 had MRI. Sufficient FFPE 123...
Loss of smell is an early and common presentation COVID-19 infection. Although it has been speculated that viral infection olfactory neurons may be the culprit, unclear whether causes injuries in bulb region.To characterize pathology associated with a postmortem study.This multicenter cohort study was conducted from April 7, 2020, to September 11, 2021. Deceased patients control individuals were included cohort. One infant congenital anomalies excluded. Olfactory tract tissue collected...
DART nanoparticles overcome critical drug delivery barriers for primary tumors and brain metastases.
Homer is a crucial postsynaptic scaffolding protein involved in both maintenance and activity-induced plasticity of the synapse. However, its quaternary structure has yet to be determined. We conducted series biophysical experiments that provide first evidence forms tetramer via coiled-coil domain, which all subunits are aligned parallel orientation. To test importance tetrameric for functionality, we engineered dimeric by deleting part domain or replacing it with artificially from yeast...
Abstract Glioblastoma multiforme (GBM) and other solid malignancies are heterogeneous contain subpopulations of tumor cells that exhibit stem-like features. Our recent findings point to a dedifferentiation mechanism by which reprogramming transcription factors Oct4 Sox2 drive the phenotype in glioblastoma, part, differentially regulating subsets miRNAs. Currently, molecular mechanisms miRNAs coordinate cancer stem cell tumor-propagating capacity unclear. In this study, we identified...
To characterize the mechanism of Zika virus (ZIKV)-associated microcephaly, we performed immunolabeling on brain tissue from a 20-week fetus with intrauterine ZIKV infection. Although demonstrated wide range neuronal and non-neuronal tropism, infection rate was highest in intermediate progenitor cells immature neurons. Apoptosis observed both infected uninfected bystander cortical neurons, suggesting role for paracrine factors induction apoptosis. Our results highlight differential...
Abstract Members of the miR-125 family are strongly expressed in several tissues, particularly brain, but may be dysregulated cancer including adult and pediatric glioma. In this study, members were downregulated pilocytic astrocytoma (PA) as a group compared to non-neoplastic brain Agilent platform. Nanostring platform, primarily pleomorphic xanthoastrocytomas gangliogliomas. Using CISH for miR-125b, highest levels expression present grade II tumors (11/33, 33% with 3+ 3/70, 4% I tumors) (p...
Tumors with a neuronal component comprise small percentage of central nervous system (CNS) neoplasms overall, but the presence differentiation has important diagnostic, prognostic, and therapeutic implications. Insulinoma-associated protein 1 (INSM1) is transcription factor strong nuclear immunostaining in neuroendocrine cells origin; however, its expression CNS normal brain neoplastic not been fully explored. Here, we present results from large number archival tissue specimens, including...
Muscleblind-like proteins (MBNL) belong to a family of tissue-specific regulators RNA metabolism that control premessenger splicing. Inactivation MBNL causes an adult-to-fetal alternative splicing transition, resulting in the development myotonic dystrophy. We have previously shown aggressive brain cancer, glioblastoma (GBM), maintains stem-like features (glioma stem cell, GSC) through hypoxia-induced responses. Accordingly, we hypothesize here responses GBM might also include MBNL-based...
The basolateral amygdaloid complex is a site of origin for zinc-containing pathways in the brain; it also known its massive innervation medial prefrontal cortex. presence, and potential neuromodulatory role, zinc within this fundamental corticolimbic circuit has not been described. For study, neurons innervating cortex were retrogradely labeled with FluoroGold, identified using autometallography to visualize selenium precipitates. Upon quantification single-labeled double-labeled cells, 35%...
Aims Neurofibromatosis 1 (NF1) is an autosomal‐dominant cancer predisposition syndrome caused by loss of function alterations involving the NF1 locus on chromosome 17. The most common brain tumours encountered in affected patients are low‐grade gliomas (pilocytic astrocytomas), although high‐grade also observed at increased frequency. While bi‐allelic characterizes these tumours, previous studies have suggested noncoding RNA molecules (microRNA, miR) may important roles dictating glioma...
Huntingtin-interacting protein 1 (HIP1) binds inositol lipids, clathrin, actin, and receptor tyrosine kinases (RTKs). HIP1 is elevated in many tumors, its expression prognostic prostate cancer. overexpression increases levels of the RTK epidermal growth factor (EGFR) transforms fibroblasts. Here we report that phosphorylated presence EGFR platelet-derived β (PDGFβR) as well oncogenic derivatives EGFRvIII, HIP1/PDGFβR (H/P), TEL/PDGFβR (T/P). We identified a four-tyrosine "HIP1...
Abstract High‐grade gliomas (HGGs) are aggressive, treatment‐resistant, and often fatal human brain cancers. The TNF‐like weak inducer of apoptosis (TWEAK)/fibroblast growth factor‐inducible 14 (Fn14) signaling axis is involved in tissue repair after injury constitutive has been implicated the pathogenesis numerous solid Fn14 gene expressed at low levels normal, uninjured but highly primary isocitrate dehydrogenase wild‐type recurrent HGGs. aspects glioma biology including invasion...