A5006572593- Schizophrenia research and treatment
- Dementia and Cognitive Impairment Research
- Bipolar Disorder and Treatment
- Functional Brain Connectivity Studies
- Treatment of Major Depression
- Mental Health Treatment and Access
- Attention Deficit Hyperactivity Disorder
- Alzheimer's disease research and treatments
- Neuroscience and Neuropharmacology Research
- Health Systems, Economic Evaluations, Quality of Life
- Neural and Behavioral Psychology Studies
- Tryptophan and brain disorders
- Personality Disorders and Psychopathology
- Diet and metabolism studies
- Medical Imaging Techniques and Applications
- Obstructive Sleep Apnea Research
- Nicotinic Acetylcholine Receptors Study
- Advanced MRI Techniques and Applications
- Receptor Mechanisms and Signaling
- Mental Health Research Topics
- Neuroscience and Music Perception
- Child and Adolescent Psychosocial and Emotional Development
- Neural dynamics and brain function
- Down syndrome and intellectual disability research
- Genetic Syndromes and Imprinting
Albert Einstein College of Medicine
2016-2025
AstraZeneca (Brazil)
2011-2025
Alzheimer's Drug Discovery Foundation
2021
Global Alzheimer's Platform Foundation
2021
Creative Commons
2018
AstraZeneca (United States)
2010-2016
Connecticut Sea Grant
2013-2014
Wilmington University
2013
Zucker Hillside Hospital
1992-2010
Northwell Health
2003-2008
Apathy is common in neurocognitive disorders (NCD) but NCD-specific diagnostic criteria are needed.The International Society for CNS Clinical Trials Methodology Work Group convened an expert group and sought input from academia, health-care, industry, regulatory bodies. A modified Delphi methodology was followed, included extensive literature review, two surveys, meetings at international conferences, culminating a consensus meeting 2019.The final reached with more than 80% agreement on all...
Local cerebral metabolic rates were determined by positron emission tomography and the deoxyglucose method in a group of 10 chronic schizophrenic subjects before after somatic treatment eight normal subjects. Before treatment, had markedly lower absolute activity than did controls both frontal temporal regions trend toward relative hyperactivity basal ganglia area. After their approached those seen nearly all except frontal. Persistence diminished metabolism was manifested as significant...
Objective: Bipolar disorder (BPD) is associated with significant functional morbidity at a rate which particularly elevated among patients discharged from hospital. The aim of this study was to examine the degree neurocognitive test performance, measured following hospitalization for an acute affective episode, predictive recovery 1 year later. Methods: Seventy‐eight Zucker Hillside Hospital aged 18–59 years and having Structured Clinical Interview DSM‐IV diagnosis bipolar I (BPD I), II II)...
Auditory steady-state response (ASSR) abnormalities in the 40-Hz (gamma band) frequency have been observed schizophrenia and rodent studies of N-methyl D-aspartate glutamate receptor (NMDAR) hypofunction. However, extent to which ASSR resemble deficits induced by acute administration ketamine, an NMDAR antagonist, is not yet known. To address this knowledge gap, we conducted parallel EEG studies: a crossover, placebo-controlled ketamine drug challenge study healthy subjects (Study 1)...
The Multidimensional Scale of Independent Functioning (MSIF) is a new instrument for rating functional disability in psychiatric outpatients. MSIF differs from other scales by providing discrete ratings (1) role responsibility, (2) presence and level support, (3) performance quality. MSIF, which consists semistructured interview detailed anchors, was validated 114 had good criterion, discriminative, interrater, construct validity. Correlations between comparable on the Social Adjustment II...
Software that has been developed to automate and standardize comparison of 3D images is discussed. The major approaches image registration are examined. authors' reconstruction software described. Studies carried out determine the relative accuracy present methods reported. main goal authors improve on commercial SPECT algorithms provide quantification sufficient for numerical assessment tracer distribution.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML"...
A sample of 87 psychiatric inpatients known to have been assaultive while in the hospital was contrasted with a matched group nonviolent patients identify personal risk factors that distinguished two groups. Data were collected using history interview, neurological examination, and an electroencephalogram. The four identified--neurological abnormality, violent crime, suicide attempts, deviant family environment childhood--were used develop statistical model predicting which subjects newly...
Objectives: Bipolar disorder (BPD) is an affective characterized by episodes of depression and mania. Cognitive impairment in patients with BPD common recent data suggest that it may represent a trait‐like feature the illness, as persists during periods wellness co‐segregates families bipolar patients. This suggests underlying genetic predisposition towards cognitive BPD; however, there have been few studies investigating effects candidate genes on this symptom domain. The catechol‐O‐methyl...
High levels of amyloid-β (Aβ) have been associated with greater rates decline in episodic memory over 18 months healthy older adults. Serial assessments shorter time intervals may facilitate earlier detection Aβ-related i
Mismatch negativity (MMN) and P300 event-related potential (ERP) reductions in schizophrenia (SZ) reflect preattentive attention-mediated auditory processing deficits, respectively. Although both have been linked to cognitive deficits SZ, their relative contributions real-world functioning are unclear. We sought determine the functional significance of disrupted SZ by examining MMN typically disabled low-functioning patients with high levels independent role functioning. deviants infrequent...
Neurosciences clinical trials continue to have notoriously high failure rates. Appropriate outcomes selection in early is key maximizing the likelihood of identifying new treatments psychiatry and neurology. The field lacks good standards for designing outcome strategies, therefore Outcomes Research Group was formed develop promote practices selection. This article describes first published guidance on standardization process neuroscience. A minimal step defined starting as possible,...
This paper discusses a two year study on the effectiveness of learning concepts in an introductory fluid dynamics course, by teaching through video.The intention this activity was to take concept professor discussed during class, and articulate it video media using everyday examples that other students can relate to.The goals were 1) generate scenario where better learn course material requiring them teach their peers, 2) create repository videos be used subsequent iterations course.Surveys...