A5058205777- Memory and Neural Mechanisms
- Dementia and Cognitive Impairment Research
- Sleep and related disorders
- Attention Deficit Hyperactivity Disorder
- Multiple Sclerosis Research Studies
- Sleep and Wakefulness Research
- Health Systems, Economic Evaluations, Quality of Life
- Voice and Speech Disorders
- Neural and Behavioral Psychology Studies
- Posttraumatic Stress Disorder Research
- Parkinson's Disease Mechanisms and Treatments
- Stuttering Research and Treatment
- Cancer-related cognitive impairment studies
- Treatment of Major Depression
- Emotion and Mood Recognition
- Schizophrenia research and treatment
- Childhood Cancer Survivors' Quality of Life
- Glioma Diagnosis and Treatment
- Functional Brain Connectivity Studies
- Psychosomatic Disorders and Their Treatments
- Traumatic Brain Injury Research
- Dysphagia Assessment and Management
- Delphi Technique in Research
- Liver Disease and Transplantation
- Mental Health Research Topics
Takeda (United States)
2018-2025
Takeda (France)
2021
Pfizer (United States)
2004-2020
Yale University
2013-2017
Connecticut Sea Grant
2011-2017
RMIT University
2017
Imperial College London
2017
University of Iowa Hospitals and Clinics
2006
University of Connecticut
2001-2004
Jewish Community Centre Association of North America
1978
Objective: To determine whether subjective memory complaints (SMCs) are associated with performance on objective cognitive measures and psychological factors in healthy, community-dwelling older adults. Method: The cohort was composed of adults, 65 years no clinical evidence impairment (n = 125). Participants were administered: CogState computerized neurocognitive battery, Prospective Retrospective Memory Questionnaire, personality meaning-in-life measures. Results: SMCs poorer executive...
Fall risk and cognitive impairment are prevalent burdensome in Parkinson disease (PD), requiring efficacious, well-tolerated treatment.
Posttraumatic stress disorder (PTSD) has been linked to cognitive decline, but research in women is generally lacking. We examined whether trauma and elevated PTSD symptoms were associated with worse function middle-aged civilian women. A secondary objective was investigate the possible role of depression relation function.The sample comprised 14,029 Nurses' Health Study II. Lifetime exposure, lifetime symptoms, past-week depressive measured 2008. Cognitive 2014-2016 using Cogstate Brief...
Abstract Introduction The purpose of this study is to compare online neuropsychological test performance older adults across self‐reported diagnoses being cognitively normal, mild cognitive impairment, and dementia due Alzheimer's disease determine the association memory concerns family history on performance. Methods Participants completed Cogstate Brief Battery unsupervised at home. Results Data from 6463 participants over age 55 years were analyzed. Adults with diagnosis impairment...
Objective: Repeat cognitive assessment comparing post-injury performance to a pre-injury baseline is common in concussion management. Although tests are typically administered clinical settings, may be conducted individually with one-on-one supervision, group or without supervision. The extent which these different test settings affect not well understood. To assess if on the Cogstate Brief Battery (CBB) differs across completed supervision were compared those taken either but Method: A...
Treating patient populations with significant psychiatric and neurocognitive symptomatology can present a unique clinical dilemma: progress in psychotherapy be significantly fettered by cognitive deficits, whereas rehabilitation efforts ineffective because of overlay. Application mindfulness-based interventions to address either or symptoms isolation appears efficacious many contexts; however, it remains unclear whether this type intervention might help simultaneous symptomatology. In...
To better understand the nature and rate of cognitive change across adolescence, Cogstate Brief Battery (CBB) was utilized to assess psychomotor function, attention, working memory, visual learning in individuals aged 10-18 years old. Since all CBB tasks have equivalent perceptual, motor, linguistic demands as well being appropriate for both children adults, this approach allowed direct across-age comparison multiple domains. Exponential decreases reaction time linear increases accuracy were...
Background: Moderately vigorous physical activity (MVPA) provides a protective affect against cognitive decline and cardiovascular risk factors. Less is known about sedentary pastimes or non exercise (NEPA) performance. Method: 125 healthy adults 65 older with no clinical evidence of impairment were enrolled. The CogState computerized neurocognitive battery was administered. Leisure activities measured using the Community Health Activity Program for Seniors (CHAMPS). Results: Sedentary...
Neurosciences clinical trials continue to have notoriously high failure rates. Appropriate outcomes selection in early is key maximizing the likelihood of identifying new treatments psychiatry and neurology. The field lacks good standards for designing outcome strategies, therefore Outcomes Research Group was formed develop promote practices selection. This article describes first published guidance on standardization process neuroscience. A minimal step defined starting as possible,...
Visual spatial learning is impaired in mild cognitive impairment (MCI) although the nature of this not clear. This study investigated and magnitude errors made by adults with amnestic MCI (aMCI) when pattern-location paired associations a continuous manner.Visual associate was measured using Continuous Paired Associate Learning (CPAL) task which 30 who met clinical criteria for aMCI matched controls were required to learn set between patterns locations across increasing memory loads (two,...
Abstract Cognitive decline is a major health concern and identification of genes that may serve as drug targets to slow important adequately support an aging population. Whilst genetic studies cross-sectional cognition have been carried out, cognitive change less well-understood. Here, using data from the TOMMORROW trial, we investigate associations with in cognitively normal older cohort. We conducted genome-wide association study trajectories repeated measures (using generalised estimating...
Abstract People with narcolepsy type 1 (NT1), 2 (NT2), and idiopathic hypersomnia (IH) often report cognitive impairment which can be quite burdensome but is rarely evaluated in routine clinical practice. In this systematic review meta-analysis, we assessed the nature magnitude of NT1, NT2, IH studies conducted from January 2000 to October 2022. We classified tests assessing memory, executive function, attention by domain. Between-group differences were analyzed as standardized mean (Cohen’s...
Background: PF-06412562 is an orally bioavailable, selective dopamine D1/D5 receptor partial agonist with a non-catechol structure under evaluation for treatment of cognitive impairment in schizophrenia. Aims: This randomized, double-blind, placebo-controlled, parallel-group, Phase 1b study examined the pharmacokinetics and pharmacodynamics three doses (3 mg, 9 45 mg twice daily) over 15 days patients schizophrenia receiving antipsychotics. Methods: Primary endpoints included adjunctive...
Morale and Life Satisfaction measures were used as independent variables to compare elderly subjects' degrees of participation in an organized leisure program. In examining the first 6 months membership a community center 109 non-institutionalized aged, it was found that 42% became regular users age-segregated older adult program, 36% erratic users, 21% non-users. Upon comparing their morale life satisfaction ratings, low scores on these two be significantly related use services, while high...