A5062071325- Parkinson's Disease Mechanisms and Treatments
- Nerve injury and regeneration
- Nuclear Receptors and Signaling
- Neurogenesis and neuroplasticity mechanisms
- Pluripotent Stem Cells Research
- Autism Spectrum Disorder Research
- Histone Deacetylase Inhibitors Research
- Neurological disorders and treatments
- GDF15 and Related Biomarkers
- Neurological diseases and metabolism
- TGF-β signaling in diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- Axon Guidance and Neuronal Signaling
- Genetics and Neurodevelopmental Disorders
- Neuroblastoma Research and Treatments
- Muscle Physiology and Disorders
- Signaling Pathways in Disease
- Macrophage Migration Inhibitory Factor
- Mitochondrial Function and Pathology
- Mechanisms of cancer metastasis
- Writing and Handwriting Education
- Gut microbiota and health
- Neuroscience and Neuropharmacology Research
- Botulinum Toxin and Related Neurological Disorders
- Tissue Engineering and Regenerative Medicine
APC Microbiome Institute
2016-2025
University College Cork
2015-2024
Union County College
2023
Altius Institute for Biomedical Sciences
2017
National University of Ireland
2003-2008
Sullivan University
2005
Hammersmith Hospital
1996-1999
Royal London Hospital
1997
University College London
1997
University of Cambridge
1996
Abstract Background A hallmark feature of Parkinson's disease (PD) is the build‐up α‐synuclein protein aggregates throughout brain; however also expressed in enteric neurons. Gastrointestinal (GI) symptoms and pathology are frequently reported PD, including constipation, increased intestinal permeability, glial pathology, alterations to gut microbiota composition. can propagate through neuronal systems but site origin whether it be or brain, still unknown. Physical exercise associated with...
Transforming growth factor-βs (TGF-βs) constitute an expanding family of multifunctional cytokines with prominent roles in development, cell proliferation, differentiation, and repair. We have cloned, expressed, raised antibodies against a distant member the TGF-βs, growth/differentiation factor-15 (GDF-15). GDF-15 is identical to macrophage inhibitory cytokine-1 (MIC-1). GDF-15/MIC-1 mRNA protein are widely distributed developing adult CNS peripheral nervous systems, including choroid...
One of the greatest unmet needs in treatment Parkinson's disease (PD) is a disease-modifying therapy, which can halt ongoing degeneration dopaminergic neurons that characteristic this disorder. Current therapies focus on managing symptoms, rather than addressing their cause. Promising candidates for are neurotrophic factors (NTFs). NTFs secreted proteins play critical roles developing nervous system, directing and supporting specification, maturation survival specific neuronal populations....
Parkinson's disease (PD) is a neurodegenerative disorder characterised by nigrostriatal dopaminergic (DA) neurodegeneration. There critical need for neuroprotective therapies, particularly those that do not require direct intracranial administration. Small molecule inhibitors of histone deacetylases (HDIs) are in vitro and vivo models PD, however it unknown whether Class IIa-specific HDIs when administered peripherally. Here we show 6-hydroxydopamine (6-OHDA) treatment induces protein kinase...
Glial cell-line-derived neurotrophic factor (GDNF) has been shown to enhance the survival of dopaminergic neurones both in vitro and vivo, protect rodent system from neurotoxic damage. However, most previous studies have only examined short-term protective effects GDNF. We investigated long-term GDNF on a 6-hydroxydopamine (6-OHDA)-induced lesion rat medial forebrain bundle (MFB), which results complete irreversible destruction nigrostriatal pathway, is robust model Parkinson's disease. was...
Abstract Growth/differentiation factor 5 is a member of the transforming growth β superfamily, which has neurotrophic and neuroprotective effects on dopaminergic neurons both in vitro vivo. Here we investigate growth/differentiation foetal mesencephalic grafts transplanted into rat model Parkinson's disease, compare them with those glial cell line‐derived factor. Mesencephalic tissue was suspended solutions containing either or prior to transplantation left striatum rats 6‐hydroxydopamine...