A5103038451- Bacterial Infections and Vaccines
- Intensive Care Unit Cognitive Disorders
- Vector-borne infectious diseases
- Vitamin D Research Studies
- Health and Medical Studies
- Frailty in Older Adults
- Viral Infections and Vectors
- Immune Response and Inflammation
- Venous Thromboembolism Diagnosis and Management
- Cerebrospinal fluid and hydrocephalus
- Neuroinflammation and Neurodegeneration Mechanisms
- Long-Term Effects of COVID-19
- Intracerebral and Subarachnoid Hemorrhage Research
- Atrial Fibrillation Management and Outcomes
- Antiplatelet Therapy and Cardiovascular Diseases
- Antibiotics Pharmacokinetics and Efficacy
- Stress Responses and Cortisol
- Nutrition and Health in Aging
- Bartonella species infections research
- Infectious Encephalopathies and Encephalitis
- Alcoholism and Thiamine Deficiency
- Traumatic Brain Injury and Neurovascular Disturbances
- Social and Demographic Issues in Germany
- T-cell and B-cell Immunology
- Dementia and Cognitive Impairment Research
Universitätsmedizin Göttingen
2014-2024
Evangelisches Krankenhaus Göttingen-Weende
2014-2024
University of Göttingen
2006-2023
Deutsche Gesellschaft für Gefäßchirurgie und Gefäßmedizin
2021
The chemokine receptor CCR2 plays a vital role for the induction of autoimmunity in central nervous system. However, it remains unclear how pathogenic response is mediated by CCR2-bearing cells. By combining bone marrow chimerism with gene targeting we detected mild disease-modulating during experimental autoimmune encephalomyelitis, model system autoimmunity, on radio-resistant cells that was independent from targeted expression endothelia. Interestingly, absence lymphocytes did not...
Previous studies have demonstrated a potential role of brain endogenous microglia and meningeal macrophages in inflammation injury during bacterial meningitis. However, the contribution previously engrafted monocytes to this process is still unknown. We therefore used genetically labelled bone marrow-derived cells from transgenic mice expressing green fluorescent protein (GFP) under chicken beta-actin promoter deliver fluorescently diseased brain. Approximately 24 hours after Streptococcus...
Presence of BB-specific antibodies in the cerebrospinal fluid (CSF) with evidence their intrathecal production conjunction white cell count CSF and typical clinical symptoms is traditional diagnostic gold standard Lyme neuroborreliosis (LNB). Few data are available on lactate concentration European adults diagnosis acute LNB. The objective study was to investigate changes during Routine parameters [leukocyte count, protein, albumin concentrations, CSF/serum quotients (Q(Alb)), IgG, IgA IgM,...
Poor vitamin D status is associated with a higher relapse rate and earlier disability in multiple sclerosis. Based on these associations, patients sclerosis are frequently supplemented the precursor cholecalciferol, although it unclear whether this regimen of therapeutic benefit. To model consequences common practice, mice were fed for more than 3 months low, medium or high dose representative deficiency, modest disproportionally supplementation, respectively, Compared to D-deprived mice,...
Meningitis and meningoencephalitis caused by Escherichia coli are associated with high rates of mortality neurological sequelae. A prevalence disorders has been observed in geriatric populations at risk hypovitaminosis D. Vitamin D potent effects on human immunity, including induction antimicrobial peptides (AMPs) suppression T-cell proliferation, but its influence microglial cells is unknown. The purpose the present study was to determine vitamin deficiency phagocytosis rate, intracellular...
Abstract Myeloid cell recruitment is a characteristic feature of bacterial meningitis. However, the cellular mechanisms important for control Streptococcus pneumoniae infection remain largely undefined. Previous pharmacological or genetic studies broadly depleted many myeloid types within meninges, which did not allow defining function specific subsets. Herein we show that besides CD11b+Ly-6G+CCR2− granulocytes, also CD11b+Ly-6ChighCCR2+ but Ly-6ClowCCR2− monocytes were recruited in high...
Background and purpose: Studies addressing the diagnostic relevance of anti-Borrelia burgdorferi (BB) serum antibodies in patients with non-specific symptoms suspected chronic Lyme neuroborreliosis (LNB) are scarce. Methods: In this study, we enrolled within 1 year 122 LNB. One hundred fourteen had previously tested positive for BB. All received antibiotic treatment. Each patient a clinical examination measurement BB-specific antibodies. The diagnosis was made according to national...
Abstract Purpose Elderly patients with impaired vision, cognitive decline or motor/sensory disturbances of their fingers suffering from chronic-obstructive pulmonary disease (COPD) encounter difficulties in handling inhaler devices used as the cornerstones treatment obstruction. Many elderly make severe mistakes which impede adequate drug delivery to bronchioles. This multimodal training program was designed reduce number devices. Methods From October 1, 2016 September 30, 2017, a...
Meningeosis neoplastica is a diffuse metastatic spread of tumor cells in the subarachnoid space. Although first recognized 1870, systematic investigations regarding cerebrospinal fluid (CSF) constituents this condition are scarce.Routine CSF samples analyzed from 2001 to 2012 at Laboratory Clinical Neurochemistry, University Göttingen, were re-evaluated. Patients, whose contained malignant included study.Patients (n = 132, age 59.1 ± 29.1, 58% women) identified, cells. The most frequent...
The composition of the cerebrospinal fluid (CSF) is not homogeneous, and concentrations proteins from different origins diverge among ventricular, cisternal lumbar CSF fractions. Concentrations blood-derived increase brain-derived decrease ventricular to We studied whether origin portion analysed may affect results in analysis for dementia. In 16 geriatric patients with suspected normal pressure hydrocephalus [age 82.5 (76/87) years; median (25th/75th percentile)] a spinal tap 40 ml was...
In 1900, Ernst Overton found that the entry of anilin dyes through cell membranes living cells depended on lipophilicity dyes. The brain is surrounded by barriers consisting lipid layers possess several inward and outward active transport systems. absence meningeal inflammation, cerebrospinal fluid (CSF) penetration anti-infectives in humans estimated ratio area under concentration-time curve (AUC) CSF (AUC(CSF)) to serum (AUC(CSF)/AUC(S)) correlated positively with lipid-water partition...
Meningoencephalitis caused by Escherichia coli is associated with high rates of mortality and risk neurological sequelae in newborns infants older or immunocompromised adults. A prevalence disorders has been observed geriatric populations at hypovitaminosis D. In vivo, we studied the effects vitamin D3 on survival host's immune response experimental bacterial meningoencephalitis mice after intracerebral E. infection. To produce different systemic concentrations, received a low, standard,...
Among a variety of more common differential diagnoses, the aetiology acute respiratory failure includes Lyme neuroborreliosis.We report an 87-years old huntsman with unilateral phrenic nerve palsy as consequence neuroborreliosis.Although neuroborreliosis is rare cause diaphragmatic weakness, it should be considered in workup because its potentially treatable nature.
Abstract Background In the 19th century, neurosyphilis was most frequent cause of dementia in Western Europe. Now caused by syphilis has become rare Germany. We studied whether routine testing patients with cognitive abnormalities or neuropathy for antibodies against Treponema pallidum therapeutic consequences geriatric patients. Methods A electrochemiluminescence immunoassay (TP-ECLIA) is routinely performed all in-patients treated at our institution cognitve decline and no insufficient...