A5014400451- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Drug-Induced Hepatotoxicity and Protection
- Liver physiology and pathology
- Organ Transplantation Techniques and Outcomes
- Data Mining Algorithms and Applications
- Platelet Disorders and Treatments
- Hepatitis C virus research
- Mycobacterium research and diagnosis
- Recommender Systems and Techniques
- Tuberculosis Research and Epidemiology
- Web Data Mining and Analysis
- Chronic Lymphocytic Leukemia Research
- Health and Medical Research Impacts
- Cardiac Arrest and Resuscitation
- Ultrasound in Clinical Applications
- Acute Myocardial Infarction Research
- Network Security and Intrusion Detection
- Digital Marketing and Social Media
- Autoimmune Bullous Skin Diseases
- Neurofibromatosis and Schwannoma Cases
- Media Influence and Health
- Alcohol Consumption and Health Effects
- Geriatric Care and Nursing Homes
- Scheduling and Timetabling Solutions
University of Birmingham
2012-2024
University Hospitals Birmingham NHS Foundation Trust
2019-2024
Queen Elizabeth Hospital Birmingham
2019-2024
All India Institute of Medical Sciences
2023
NIHR Birmingham Biomedical Research Centre
2017-2023
Indo Soviet Friendship College of Pharmacy
2023
NIHR Birmingham Liver Biomedical Research Unit
2016-2022
National Institute for Health Research
2018-2022
Jawaharlal Institute of Post Graduate Medical Education and Research
2021
Panjab University
2021
The role of the endothelium in protecting from chronic liver disease and TGFβ-mediated fibrosis remains unclear. Here we describe how endothelial transcription factor ETS-related gene (ERG) promotes homoeostasis by controlling canonical TGFβ-SMAD signalling, driving SMAD1 pathway while repressing SMAD3 activity. Molecular analysis shows that ERG binds to SMAD3, restricting its access DNA. Ablation expression results endothelial-to-mesenchymal transition (EndMT) spontaneous fibrogenesis...
Wireless technology is one of the main areas research in world communication systems today and a study incomplete without an understanding operation fabrication antennas. The aim this paper explain basic introduction antenna brief explanation YAGI-UDA .YAGI-UDA mostly use field system YAGI –UDA antenna.
Abstract Acetaminophen (APAP) is the main cause of acute liver failure in West. Specific efficacious therapies for (ALF) are limited and time-dependent. The mechanisms that drive irreversible remain poorly characterized. Here we report recently discovered platelet receptor CLEC-2 (C-type lectin-like receptor) perpetuates worsens damage after toxic injury. Our data demonstrate blocking signalling enhances recovery from injuries (APAP carbon tetrachloride) by increasing tumour necrosis...
Over the past decade, endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) has become an indispensable tool in diagnostic armamentarium of pulmonologist. As expertise with EBUS-TBNA evolved and several innovations have occurred, indications for its use expanded. However, aspects are still not standardized. Hence, evidence-based guidelines needed to optimize yield safety EBUS-TBNA. For this purpose, a working group experts from India was constituted. A detailed...
In the United States, distance from liver transplant center correlates with worsened outcomes; effects of geography elsewhere are unassessed. We performed a national registry analysis Kingdom listings for transplantation (1995-2014) and assessed whether travel time to outcome. There were 11 188 (8490 transplanted), median 60 minutes (range 36-86). Of population, 3.38 × 107 (55.1%) reside ≥60 center, 7.65 106 (12.5%) >119 minutes. After competing risk analysis, increasing was associated an...
As a result of the increasing incidence cirrhosis in UK, more patients with chronic liver disease are being considered for elective non-hepatic surgery. A historical reluctance to offer surgery such stems from general perceptions poor postoperative outcomes. While this is true those decompensated cirrhosis, selected compensated early-stage can have good outcomes after careful risk assessment. Well-recognised risks include anaesthesia, bleeding, infections, impaired wound healing, acute...
Background Metabolic Syndrome (MS) and chronic oral condition (periodontitis [PD]) are state of inflammation. The study was conducted to determine alterations in serum salivary cytokines level MS and/or PD the North Indian population. Materials Methods This cross‐sectional carried out northern part India. subjects similar ethnicity were recruited according International Diabetes Federation (IDF) criteria for MS, while diagnosed on basis packet depth clinical attachment level. ELISA method...
Abstract Platelet C-type lectin-like receptor 2 (CLEC-2) is a hem-immunoreceptor tyrosine–based activation motif-containing that has critical role in venous thrombosis but minimal involvement hemostasis. CLEC-2 can be blocked by Btk inhibitors. Treatment with ibrutinib associated increased bleeding due to off-target inhibition of Src family kinases (SFKs). Patients X-linked agammaglobulinemia (XLA) who lack Btk, however, do not bleed, suggesting selective as viable antithrombotic strategy....
Purpose The purpose of this paper is to examine the effect interactivity and game-product congruence on players’ feelings presence their brand attitude in context in-game advertising. Specifically, research illustrates conditions under which placements digital games create attention, engagement, subsequent by drawing insights from “limited capacity model attention,” “vividness effects theory” “transportation theory.” Design/methodology/approach A 2 (interactivity: high or low)×2...
Isolated posterior ST-elevation myocardial infarction (STEMI) accounts for up to 7% of STEMIs. The diagnosis is suggested by indirect anterior-lead ECG changes. Confirmation requires presence in posterior-leads (V7-V9). We investigated the ability hospital doctors and paramedics diagnose STEMI (PMI).Doctors emergency department acute medical unit at two teaching hospitals West Midlands Ambulance Service Paramedics were asked interpret a 12-lead illustrating ST-depression dominant R-wave...
Developing new treatments that improve outcomes for patients with decompensated cirrhosis remains an unmet area of clinical need. The UK has a rich history being on the forefront trials this patient group. However, there have been challenges in achieving goal past decade, several negative studies as well struggling to achieve recruitment. This further exacerbated by changed landscape following COVID-19 pandemic. In response this, O’Shaughnessy report was commissioned identify potential...
A patient with Churg-Strauss vasculitis presenting mononeuritis multiplex, who developed obstructive jaundice, is described. On investigation the jaundice proved to be due ascaris infestation. As immune abnormalities associated infection are also typical of those seen in syndrome it speculated that occurred because a failure regulate anti-ascaris response.