A5081262250- Adipokines, Inflammation, and Metabolic Diseases
- Adipose Tissue and Metabolism
- Liver Disease Diagnosis and Treatment
- Lipid metabolism and disorders
- Atherosclerosis and Cardiovascular Diseases
- Dietary Effects on Health
- Immune Cell Function and Interaction
- Metabolism, Diabetes, and Cancer
- CAR-T cell therapy research
- Fibroblast Growth Factor Research
- Lipoproteins and Cardiovascular Health
- Cholesterol and Lipid Metabolism
- Amino Acid Enzymes and Metabolism
- Lipid metabolism and biosynthesis
- Epigenetics and DNA Methylation
- Immune cells in cancer
- Immune Response and Inflammation
- Cancer, Hypoxia, and Metabolism
- Acute Lymphoblastic Leukemia research
- Glycosylation and Glycoproteins Research
- Diet, Metabolism, and Disease
- Diet and metabolism studies
- Single-cell and spatial transcriptomics
- Proteoglycans and glycosaminoglycans research
- Advanced Glycation End Products research
German Cancer Research Center
2014-2024
Heidelberg University
2014-2024
Goethe University Frankfurt
2021-2023
University Hospital Heidelberg
2013-2018
DKFZ-ZMBH Alliance
2013-2017
German Center for Diabetes Research
2016
Utrecht University
2003-2004
University Medical Center Utrecht
2003
The role and molecular mechanisms of intermittent fasting (IF) in non-alcoholic steatohepatitis (NASH) its transition to hepatocellular carcinoma (HCC) are unknown. Here, we identified that an IF 5:2 regimen prevents NASH development as well ameliorates established fibrosis without affecting total calorie intake. Furthermore, the blunted NASH-HCC when applied therapeutically. timing, length, number cycles type diet were critical parameters determining benefits fasting. Combined proteome,...
Atherosclerosis is a low-grade inflammatory disease involving leukocytes, lipids, and glucose leading to endothelial dysfunction. Since activation of neutrophils by triglycerides has been described in vitro, we hypothesized that the postprandial phase an state affecting possibly contributing We measured blood leukocyte counts, cytokines, hydroperoxides (HPOs), flow-mediated vasodilation (FMD) eight healthy males (age 23 ± 2 years) after FAT (50 g/m2) GLUCOSE challenge (37.5 g/m2),...
Dietary protein intake is linked to an increased incidence of type 2 diabetes (T2D). Although dietary dilution (DPD) can slow the progression some aging-related disorders, whether this strategy affects development and risk for obesity-associated metabolic disease such as T2D unclear. Here, we determined that DPD in mice humans increases serum markers health. In lean mice, promoted inefficiency by increasing carbohydrate fat oxidation. nutritional polygenic murine models obesity, prevented...
Background: Nutrients are transported through endothelial cells before being metabolized in muscle cells. However, little is known about the regulation of transport processes. Notch signaling a critical regulator metabolism and angiogenesis during development. Here, we studied how genetic pharmacological manipulation adult mice affects fatty acid transport, cardiac angiogenesis, heart function. Methods: Endothelial-specific inhibition was achieved by conditional inactivation Rbp-jκ to...
Type 2 diabetes arises from insulin resistance of peripheral tissues followed by dysfunction β-cells in the pancreas due to metabolic stress. Both depletion and supplementation neutral amino acids have been discussed as strategies improve sensitivity. Here we characterise mice lacking intestinal renal acid transporter B0AT1 (Slc6a19) a model study consequences selective acids. Metabolic tests, analysis metabolite levels signalling pathways were used (Slc6a19). Reduced uptake intestine loss...
Regulatory T (Treg) cells are critical determinants of both immune responses and metabolic control. Here we show that systemic ablation Treg compromised the adaptation whole-body energy expenditure to cold exposure, correlating with impairment in thermogenic marker gene expression massive invasion pro-inflammatory macrophages brown adipose tissue (BAT). Indeed, BAT harbored a unique sub-set characterized by signature. As these respond activation upon this study defines BAT-specific direct...
OBJECTIVE—The cholesteryl ester transfer protein (CETP) plays a key role in the remodeling of triglyceride (TG)-rich and HDL particles. Sequence variations CETP gene may interfere with effect lipid-lowering treatment type 2 diabetes. RESEARCH DESIGN AND METHODS—We performed 30-week randomized double-blind placebo-controlled trial atorvastatin 10 mg (A10) 80 (A80) 217 unrelated patients RESULTS—CETP TaqIB A-629C polymorphisms were tightly concordant (P < 0.001). At baseline, B1B1...
Mice require testicular glycosphingolipids (GSLs) for proper spermatogenesis. Mutant mice strains deficient in specific genes encoding biosynthetic enzymes of the GSL pathway including Galgt1 (encoding GM2 synthase) and Siat9 GM3 have been established lacking various overlapping subsets GSLs. Although male Galgt1-/- are infertile, Siat9-/- fertile. Interestingly, GSLs thought to be essential spermatogenesis not synthesized either these strains. Hence, cannot account different phenotypes. A...
In mammals, proper storage and distribution of lipids in between tissues is essential for the maintenance energy homeostasis. Here, we show that tumour growth triggers hepatic metabolic dysfunction as part cancer cachectic phenotype, particularly by reduced very-low-density-lipoprotein (VLDL) secretion hypobetalipoproteinemia. As a molecular cachexia output pathway, levels transcription factor transforming beta 1-stimulated clone (TSC) 22 D4 were increased cachexia. Mimicking high TSC22D4...
Significance G protein–coupled receptors (GPCRs) are important regulators of cellular and biological functions primary targets therapeutic drugs. About 100 mammalian GPCRs still considered orphan because they lack a known endogenous ligand. We report the deorphanization GPR182, which is expressed in endothelial cells microvasculature. show that GPR182 an atypical chemokine receptor, binds CXCL10, 12, 13. However, binding does not induce downstream signaling. Consistent with scavenging...
The Forkhead family of transcription factors comprises numerous members and is implicated in various cellular functions, including cell growth, apoptosis, migration, differentiation. In this study, we identified the factor FoxQ1 as increased expression during TGF-β1 induced changes epithelial differentiation, suggesting functional roles for plasticity. repression mammary cells led to a change morphology characterized by an increase size, pronounced cell-cell contacts, several junction...
Presence of thermogenically active adipose tissue in adult humans has been inversely associated with obesity and type 2 diabetes. While it had shown that insulin is crucial for the development classical brown fat, its role function inducible brown-in-white (brite) less clear. Here we show deficiency impaired differentiation brite adipocytes. However, adrenergic stimulation almost fully induced thermogenic program under these settings. Although adipocytes as well browning white entailed...
Extracellular matrix remodeling is required for adipose expansion under increased caloric intake. In turn, inhibited expandability due to aberrant collagen deposition promotes insulin resistance and progression towards the metabolic syndrome. An emerging role small leucine-rich proteoglycan Lumican in metabolically driven nonalcoholic fatty liver disease sparks an interest further understanding its diet-induced obesity complications. Whole body ablation of (Lum−/−) gene adeno-associated...
Research Article3 May 2016Open Access Transparent process Fasting-induced liver GADD45β restrains hepatic fatty acid uptake and improves metabolic health Jessica Fuhrmeister Joint Division Molecular Metabolic Control, German Cancer Center, Center for Biology, Heidelberg University Hospital, Heidelberg, Germany Search more papers by this author Annika Zota Institute Diabetes (IDC), Helmholtz Munich, Neuherberg, Heidelberg-IDC Translational Program, Inner Medicine I, Tjeerd P Sijmonsma Oksana...
Abstract Obesity-related insulin resistance represents the core component of metabolic syndrome, promoting glucose intolerance, pancreatic beta cell failure and type 2 diabetes. Efficient safe sensitization control remain critical therapeutic aims to prevent diabetic late complications Here, we identify transforming growth factor beta-like stimulated clone (TSC) 22 D4 as a molecular determinant signalling handling. Hepatic TSC22D4 inhibition both prevents reverses hyperglycaemia, intolerance...
Abstract Sulfoglycolipids are present on the surface of a variety cells. The sulfatide SM4s is increased in lung, renal, and colon cancer associated with an adverse prognosis, possibly due to low immunoreactivity tumor. As macrophages significantly contribute inflammatory infiltrate malignancies, we postulated that may modulate macrophage function. We have investigated effect uptake apoptotic tumor cells, cytokine profile, receptor expression. Using flow cytometry microscopic analyses, found...