A5007888182- Single-cell and spatial transcriptomics
- Hematopoietic Stem Cell Transplantation
- Cancer Genomics and Diagnostics
- Immune Cell Function and Interaction
- Blood properties and coagulation
- CAR-T cell therapy research
- Epigenetics and DNA Methylation
- T-cell and B-cell Immunology
- MicroRNA in disease regulation
- Platelet Disorders and Treatments
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Receptor Mechanisms and Signaling
- Chemokine receptors and signaling
- Acute Lymphoblastic Leukemia research
- Immune cells in cancer
- Histone Deacetylase Inhibitors Research
- Acute Myeloid Leukemia Research
- Erythrocyte Function and Pathophysiology
Goethe University Frankfurt
2021-2025
University Hospital Frankfurt
2021-2023
Frankfurt Cancer Institute
2023
German Cancer Research Center
2021
Heidelberg University
2021
Significance G protein–coupled receptors (GPCRs) are important regulators of cellular and biological functions primary targets therapeutic drugs. About 100 mammalian GPCRs still considered orphan because they lack a known endogenous ligand. We report the deorphanization GPR182, which is expressed in endothelial cells microvasculature. show that GPR182 an atypical chemokine receptor, binds CXCL10, 12, 13. However, binding does not induce downstream signaling. Consistent with scavenging...
Despite a high clinical need for the treatment of colorectal carcinoma (CRC) as second leading cause cancer-related deaths, targeted therapies are still limited. The multifunctional enzyme Transglutaminase 2 (TGM2), which harbors transamidation and GTPase activity, has been implicated in development progression different types human cancers. However, mechanism role TGM2 cancer poorly understood. Here, we present promising drug target.In primary patient material CRC patients, detected an...
Abstract Uncovering early gene network changes of human hematopoietic stem cells (HSCs) leading to differentiation induction is utmost importance for therapeutic manipulation. We employed single cell proteo-transcriptomic sequencing FACS-enriched bone marrow and progenitor (HSPCs) from 15 healthy donors. Pseudotime analysis reveals four major trajectories, which remain consistent upon aging, with an branching point into megakaryocyte-erythroid progenitors. However, young donors suggest a...
Patients with multiple myeloma (MM) routinely receive mRNA-based vaccines to reduce COVID-19-related mortality. However, whether disease- and therapy-related alterations in immune cells cytokine-responsiveness contribute the observed heterogeneous vaccination responses is unclear. Thus, we analyzed peripheral blood mononuclear from patients MM during after SARS-CoV-2 breakthrough infection (BTI) using combined whole-transcriptome surface proteome single-cell profiling functional serological...
Topic: 1. Acute lymphoblastic leukemia - Biology & Translational Research Background: While remission rates are >90% after first-line therapy in adult B-cell precursor acute (BCP-ALL), the prognosis relapse is dismal with survival under 10%. Relapse may arise from remaining therapy-resistant leukemia-initiating cells (LICs) exhibiting specific gene expression pattern. Aims: Consequently, identification of cellular architecture and phenotypical plasticity BCP-ALL vivo key importance...