A5051638599- Thyroid Cancer Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
- Thyroid and Parathyroid Surgery
- Lung Cancer Research Studies
- Adrenal and Paraganglionic Tumors
- Pituitary Gland Disorders and Treatments
- Sepsis Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Hormonal Regulation and Hypertension
- Pancreatic and Hepatic Oncology Research
- Cardiac, Anesthesia and Surgical Outcomes
- Brucella: diagnosis, epidemiology, treatment
- Intestinal and Peritoneal Adhesions
- Parathyroid Disorders and Treatments
- Immune Response and Inflammation
- Salmonella and Campylobacter epidemiology
- Neurofibromatosis and Schwannoma Cases
- Vitamin D Research Studies
- Colorectal Cancer Screening and Detection
- Thyroid Disorders and Treatments
- Adrenal Hormones and Disorders
- Respiratory Support and Mechanisms
- Burkholderia infections and melioidosis
- Genetic Syndromes and Imprinting
- Airway Management and Intubation Techniques
Philipps University of Marburg
2018-2025
Universitätsklinikum Gießen und Marburg
2018-2025
University of Hohenheim
2021-2025
Klinikum Magdeburg
2018-2023
University Hospital Frankfurt
2009-2021
Goethe University Frankfurt
2011-2021
Martin Luther University Halle-Wittenberg
2021
Hanusch Hospital
2019
University of Stuttgart
2018-2019
Frankfurt Cancer Institute
2018
Background Acoustic Radiation Force Impulse (ARFI)-Imaging is an ultrasound-based elastography method enabling quantitative measurement of tissue stiffness. The aim the present study was to evaluate sensitivity and specificity ARFI-imaging for differentiation thyroid nodules compare it well evaluated qualitative real-time (RTE). Methods involves mechanical excitation using acoustic pulses generate localized displacements resulting in shear-wave propagation which tracked correlation-based...
Aminophosphonates, like glyphosate (GS) or metal chelators such as ethylenediaminetetra(methylenephosphonic acid) (EDTMP), are released on a large scale worldwide. Here, we have characterized bacterial strain capable of degrading synthetic aminophosphonates. The was isolated from LC/MS standard solution. Genome sequencing indicated that the belongs to genus Ochrobactrum. Whole-genome classification using pyANI software compute pairwise ANI and other metrics between Brucella assemblies...
Objective: Work-up of thyroid nodules remains challenging. Recent technologies enable determination tissue elasticity and perfusion using ultrasound devices. The aim the present study was to evaluate real-time elastography (RTE) contrast-enhanced with Sonovue (CEUS) for differentiation benign malignant nodules.
To assess anxiety and depression symptoms, suicidal ideation, health-related quality of life (HRQOL) in a large series consecutive patients with primary hyperparathyroidism (pHPT) before after parathyroidectomy.This prospective multicenter study investigated preoperative postoperative depression, anxiety, HRQOL pHPT compared these variables control group nontoxic thyroid nodules.The included 194 186 subjects.Depression was evaluated the Hospital Anxiety Depression Scale (HADS) Patient Health...
Pluripotent stem cells must strictly maintain genomic integrity to prevent transmission of mutations. In human induced pluripotent (iPSCs), we found that genome surveillance is achieved via two ways, namely, a hypersensitivity apoptosis and very low accumulation DNA lesions. The threshold was mediated by constitutive p53 expression marked upregulation proapoptotic target genes the BCL-2 family, ensuring efficient iPSC removal upon genotoxic insults. Intriguingly, despite elevated...
Few available data indicate that a mutation-based "neoadjuvant" therapy in advanced anaplastic thyroid carcinoma (ATC) might convert an initially unresectable primary tumor to resectable and optimize local control. We evaluated preoperative short-term with BRAF-directed or, case of BRAF non-mutated tumors, mKI/checkpoint inhibitor combination three patients ATC stage IVB C.
Vitamin D receptor (VDR) expression has been shown to be upregulated in several tumors and is supposed represent an important endogenous response tumor progression. To investigate the role of VDR gene its influence on 25(OH)D(3) 1,25(OH)(2)D(3) plasma levels thyroid carcinoma, we analyzed four polymorphisms patients healthy controls (HC).Patients with carcinoma (n = 172) 132 for papillary n 40 follicular) HC 321) were genotyped ApaI (rs7975232), TaqI (rs731236), BsmI (rs1544410), FokI...
Brucellosis is a highly contagious and incapacitating disease of humans, livestock wildlife species globally. Treatment brucellosis in animals not recommended, combinations antibiotics recommended by the World Health Organization are used. However, sporadic antimicrobial-resistant (AMR) isolates relapse cases have been reported from different endemic regions. In current study, molecular characterization antibiotic susceptibility testing using microdilution method for 35
The presence of fetal cells in a maternal compartment is defined as fetal-maternal microchimerism, which has been detected thyroids mothers suffering from autoimmunity. We analyzed the immunohistology paraffin-embedded thyroid specimen taken at surgery 49 women with Hashimoto's thyroiditis (n = 25), Graves' disease 15), or nodular diffuse follicular adenomas 9), whose childbirth history was positive for sons. By fluorescence situ hybridization we screened X-chromosome- and...
Common polymorphisms of the vitamin D receptor gene have been reported to affect risk breast, colon, prostate, and differentiated thyroid cancer (DTC), but within genes metabolizing enzymes not studied in DTC. The aim present study was investigate for patients with DTC healthy controls (HC) as well (25-hydroxyvitamin D(3), 1,25-hydroxyvitamin) status.German (n=253) (papillary carcinoma [PTC] follicular [FTC]) HC (n=302) were genotyped such 25-hydroxylase (CYP2R1[rs12794714, rs10741657]),...
Single nucleotide polymorphisms (SNPs) near thyroid transcription factor genes (FOXE1 rs965513/NKX2-1 rs944289) have been shown to be associated with differentiated cancer (DTC) in Caucasoid populations. We investigated the role of those SNPs German patients DTC and also extended our analysis tumor stages lymphocytic infiltration tumors (ITL).Patients (n=243; papillary, PTC; follicular, FTC) healthy controls (HC; n=270) were analyzed for rs965513 rs944289 SNPs.The case-control SNP showed...
Data on intratumoral heterogeneity of small intestine neuroendocrine tumors (SI-NETs) and related liver metastasis are limited. The aim this study was to characterize genetic 5 patients with SI-NETs. Therefore, formalin-fixed, paraffin-embedded tissue samples primary metastatic lesions as well benign five synchronously metastasized, differentiated SI-NETs were analyzed whole exome sequencing. For one patient, chip based 850k DNA methylome analysis performed tumor control tissue. Thereby, 156...
Despite a high clinical need for the treatment of colorectal carcinoma (CRC) as second leading cause cancer-related deaths, targeted therapies are still limited. The multifunctional enzyme Transglutaminase 2 (TGM2), which harbors transamidation and GTPase activity, has been implicated in development progression different types human cancers. However, mechanism role TGM2 cancer poorly understood. Here, we present promising drug target.In primary patient material CRC patients, detected an...
Ziel: Nebennierenraumforderungen können sonografisch mit guter Sensitivität und Spezifität detektiert werden. Ziel der vorliegenden Studie war es, die Wertigkeit Kontrastmittel-Sonografie (CEUS) unter Verwendung von Zeit-Intensitäts-Kurven für Charakterisierung zu evaluieren. Material Methoden: 108 Patienten 116 Raumforderungen Nebennieren erhielten einen Ultraschall Nebenniere, inklusive einer dem Kontrastmittel Sonovue. Die Kontrastmitteldynamik wurde mittels Zeit-Intensitätskurven...
Abstract Purpose In patients with pheochromocytoma current guidelines recommend preoperative alpha-adrenoceptor blockade selective or nonselective antagonists for at least 7–14 days. To date, no information exists about orally administered urapidil retard, a short-acting antagonist. Methods The medical records of consecutive between 2010 and 2023 were reviewed. Patients received phenoxybenzamine 2017, intravenous was given 2017 2019. Orally retard has been used from 2019 until present....
European and German consensus guidelines advocate preoperative therapy with α-adrenoreceptor antagonists in symptomatic patients catecholamine-producing pheochromocytomas paragangliomas (PPGLs) to avoid hypertensive crisis during adrenalectomy. This practice has been questioned recently. work aimed assess current management of PPGLs across disciplines. The study was conducted from November 2023 February 2024 using the Delphi technique. Two consecutive surveys were conceived by a steering...