A5043408739- Vitamin D Research Studies
- Diabetes and associated disorders
- Adrenal Hormones and Disorders
- Hormonal Regulation and Hypertension
- Digestive system and related health
- Thyroid Disorders and Treatments
- Thyroid Cancer Diagnosis and Treatment
- Diet and metabolism studies
- Pancreatic function and diabetes
- Immune Cell Function and Interaction
- Diabetes Management and Research
- Celiac Disease Research and Management
- Adipokines, Inflammation, and Metabolic Diseases
- Estrogen and related hormone effects
- Growth Hormone and Insulin-like Growth Factors
- FOXO transcription factor regulation
- Pituitary Gland Disorders and Treatments
- Nutrition, Genetics, and Disease
- Vitamin C and Antioxidants Research
- Erythrocyte Function and Pathophysiology
- Electrolyte and hormonal disorders
- Myasthenia Gravis and Thymoma
- Hepatitis C virus research
- T-cell and B-cell Immunology
- Cancer Research and Treatment
Goethe University Frankfurt
2013-2024
University Hospital Frankfurt
2012-2021
Endokrinologikum
2012
München Klinik Bogenhausen
2004-2005
Several studies have shown a reduced quality of life in patients with Addison's disease, but little is known about the potential influences.We determined 200 disease using an disease-specific quality-of-life questionnaire. Data first symptoms, time to diagnosis and current medication were collected by questionnaires.With increasing latency between symptoms adrenal insufficiency, decreased highly significant manner (p<0.001). Age at manifestation correlated negatively (p=0.01). Significantly...
Vitamin D receptor (VDR) expression has been shown to be upregulated in several tumors and is supposed represent an important endogenous response tumor progression. To investigate the role of VDR gene its influence on 25(OH)D(3) 1,25(OH)(2)D(3) plasma levels thyroid carcinoma, we analyzed four polymorphisms patients healthy controls (HC).Patients with carcinoma (n = 172) 132 for papillary n 40 follicular) HC 321) were genotyped ApaI (rs7975232), TaqI (rs731236), BsmI (rs1544410), FokI...
The aim of our study was to investigate the influence a 6-month vitamin D supplementation in patients with noninsulin-requiring type 2 diabetes mellitus. We included 86 placebo-controlled, randomised, double-blind study. During 6 months received Vigantol oil once week corresponding daily dose 1904 IU or placebo oil, followed by follow-up. At start and at 3-month intervals 25OHD, PTH, body mass index, HbA1c, insulin, C-peptide, homeostasis model assessment-index were measured. primary outcome...
Common polymorphisms of the vitamin D receptor gene have been reported to affect risk breast, colon, prostate, and differentiated thyroid cancer (DTC), but within genes metabolizing enzymes not studied in DTC. The aim present study was investigate for patients with DTC healthy controls (HC) as well (25-hydroxyvitamin D(3), 1,25-hydroxyvitamin) status.German (n=253) (papillary carcinoma [PTC] follicular [FTC]) HC (n=302) were genotyped such 25-hydroxylase (CYP2R1[rs12794714, rs10741657]),...
Single nucleotide polymorphisms (SNPs) near thyroid transcription factor genes (FOXE1 rs965513/NKX2-1 rs944289) have been shown to be associated with differentiated cancer (DTC) in Caucasoid populations. We investigated the role of those SNPs German patients DTC and also extended our analysis tumor stages lymphocytic infiltration tumors (ITL).Patients (n=243; papillary, PTC; follicular, FTC) healthy controls (HC; n=270) were analyzed for rs965513 rs944289 SNPs.The case-control SNP showed...
Abstract Background Type 1 diabetes mellitus (T1D) is mediated by autoaggressive T effector cells with an underlying regulatory T‐cell (Treg) defect. Vitamin D deficiency highly prevalent in T1D, which can aggravate immune dysfunction. High‐dose vitamin treatment may enhance Tregs and improve metabolism T1D patients. Methods In a randomized double‐blind placebo‐controlled trial crossover design, patients received either for 3 months cholecalciferol 4000 IU/d followed placebo or the...
The mechanisms behind destruction of the adrenal glands in autoimmune Addison's disease remain unclear. Autoantibodies against steroid 21-hydroxylase, an intracellular key enzyme cortex, are found >90% patients, but these autoantibodies not thought to mediate disease. In this article, we demonstrate highly frequent 21-hydroxylase-specific T cells detectable 20 patients with Using overlapping 18-aa peptides spanning full length identified immunodominant CD8(+) and CD4(+) cell responses a...
Background: Protective effects of vitamin D have been reported in autoimmune and malignant thyroid diseases, though little is known about the underlying mechanism. Sirtuin 1 histon deacethylase (SIRT1) links pathway with regulation transcription factor FOXO3a, a key player cell cycle apoptosis. Aim present study was to investigate common single nucleotide polymorphisms (SNP's) FOXO3a gene respect as well evaluate hypothesis Sirtuin1-FOXO3a interaction being mediator anti-proliferative...
Background Gene variants known to contribute Autoimmune Addison's disease (AAD) susceptibility include those at the MHC, MICA, CIITA, CTLA4, PTPN22, CYP27B1, NLRP-1 and CD274 loci. The majority of genetic component has yet be accounted for. Aim To investigate role 19 candidate genes in AAD six European case-control cohorts. Methods A sequential association study design was employed with genotyping using Sequenom iPlex technology. In phase one, 85 SNPs were genotyped UK Norwegian cohorts (691...
Sphingolipids are characterized by a broad range of bioactive properties. Particularly, the development insulin resistance, major pathophysiological hallmark Type 2 Diabetes mellitus (T2D), has been linked to ceramide signaling. Since vitamin D supplementation may slow down T2D progression improving glucose concentrations and sensitivity, we investigated whether impacts on plasma sphingolipid levels in patients. Thus, samples 59 patients with non-insulin-requiring from placebo-controlled,...
Summary Vitamin D (VD) has been implicated in type 1 diabetes (T1D) by genetic and epidemiological studies. Individuals living regions with low sunlight exposure have an increased T1D risk VD supplementation reduced the human individuals mouse models. One possibility of how influences pathogenesis is its immunomodulatory effect on dendritic cells (DC), which then preferentially activate regulatory T (Tregs). In present pilot study, we collected blood samples from a small cohort patients at...
Background Different parameters have been determined for prediction of treatment outcome in hepatitis c virus genotype 1 infected patients undergoing pegylated interferon, ribavirin combination therapy. Results on the importance vitamin D levels are conflicting. In present study, a comprehensive analysis before and during therapy together with single nucleotide polymorphisms involved metabolism context other known predictors has performed. Methods well characterized prospective cohort 398...
Three genes have been confirmed as major joint susceptibility for endocrine autoimmune disease:human leukocyte antigen class II, cytotoxic T-lymphocyte 4 and protein tyrosine phosphatase non-receptor type 22. Recent studies showed that a genetic variation within the interferon induced helicase domain 1 (IFIH1) locus (rs1990760 polymorphism) is an additional risk factor in diabetes Graves' disease (GD). The aim of present study was to investigate role rs1990760 polymorphism IFIH1 gene German...
Abstract Background Polymorphisms within the insulin gene can influence expression in pancreas and especially thymus, where self-antigens are processed, shaping T cell repertoire into selftolerance, a process that protects from β-cell autoimmunity. Methods We investigated role of -2221Msp(C/T) -23HphI(A/T) polymorphisms patients with monoglandular autoimmune endocrine disease [patients isolated type 1 diabetes (T1D, n = 317), Addison's (AD, 107) or Hashimoto's thyroiditis (HT, 61)], those...
Autoimmune endocrinopathies result from environmental triggers on the genetic background of risk alleles, especially HLA-DR and HLA-DQ with alanine (Ala) in HLA-DQB1 position 57 (Ala57), whereas amino acid Asp57 is protective.Differentiate effects variants at adult patients isolated autoimmune polyglandular syndrome type 2 (APS-2) compared healthy controls relation to gender.University Hospital Frankfurt, Germany.Two hundred seventy-eight APS-2 1373 endocrinopathies: [type 1 diabetes (T1D),...