A5074269585- Diabetes and associated disorders
- Adrenal Hormones and Disorders
- Hormonal Regulation and Hypertension
- Pancreatic function and diabetes
- Diabetes Management and Research
- Pituitary Gland Disorders and Treatments
- Transgenic Plants and Applications
- Immune Cell Function and Interaction
- Growth Hormone and Insulin-like Growth Factors
- T-cell and B-cell Immunology
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Thyroid Disorders and Treatments
- Hormonal and reproductive studies
- Diet, Metabolism, and Disease
- Ovarian function and disorders
- Toxin Mechanisms and Immunotoxins
- Vitamin D Research Studies
- Diet and metabolism studies
- Viral Infectious Diseases and Gene Expression in Insects
- Plant tissue culture and regeneration
- Immunodeficiency and Autoimmune Disorders
- Stress Responses and Cortisol
- Celiac Disease Research and Management
- Systemic Lupus Erythematosus Research
- CRISPR and Genetic Engineering
University of Perugia
2015-2024
Atrium Health Wake Forest Baptist
2017
Universitat de València
2017
University of Nottingham
2017
Università degli Studi Internazionali di Roma
2014
Collegio Carlo Alberto
2010
University of Modena and Reggio Emilia
2009
Karolinska University Hospital
1995-2006
University of Turin
2004
Universidade Federal de São Paulo
2000
Recent observations suggest the involvement of gastrointestinal tract in pathogenesis islet autoimmunity. Thus, modulation gut-associated lymphoid tissue may represent a means to affect natural history disease. Oral administration probiotic bacteria can modulate local and systemic immune responses; consequently, we investigated effects oral compound VSL#3 on occurrence diabetes non-obese diabetic (NOD) mice.VSL#3 was administered female NOD mice three times week starting from 4 weeks age. A...
Activating mutations of BRAF have been identified in a variety human cancers, most notably melanomas and papillary thyroid carcinomas (PTCs). The aim the present study was to disclose role carcinoma development. Seventy-two tumors, including 60 PTCs, six follicular adenomas, five carcinomas, one anaplastic carcinoma, were studied. mutation screening focused on exon 15 11 gene by single-stranded conformational polymorphism sequence analysis. Search RET/PTC expression conducted with RT-PCR...
In autoimmune polyendocrinopathy syndrome type I (APS-I), mutations in the regulator gene (AIRE) impair thymic self-tolerance induction developing T cells. The ensuing autoimmunity particularly targets ectodermal and endocrine tissues, but chronic candidiasis usually comes first. We recently reported apparently APS-I-specific high-titer neutralizing autoantibodies against interferons 100% of Finnish Norwegian patients, mainly with two prevalent AIRE truncations.Because variability clinical...
Abstract Autoimmune Addison’s disease (AAD) is characterized by the autoimmune destruction of adrenal cortex. Low prevalence and complex inheritance have long hindered successful genetic studies. We here report first genome-wide association study on AAD, which identifies nine independent risk loci ( P < 5 × 10 −8 ). In addition to implicated in lymphocyte function development shared with other diseases such as HLA , BACH2 PTPN22 CTLA4 we associate two protein-coding alterations Regulator...
Autoantibodies against 21-hydroxylase (P450c21) are common in idiopathic autoimmune Addison's disease. In the present work, we have developed a sensitive radiobinding assay using vitro translated recombinant human 35S-P450c21. Levels of P450c21 antibodies (P450c21-Ab) were expressed as relative index (P450c21 index) P450c21-Ab positive Addisonian serum and two antibody-negative healthy sera negative standards individuals. The upper level normal was mean + 3 SD. Positivity for confirmed by...
Abstract The major histocompatibility complex class I chain-related MIC-A and MIC-B genes are located on chromosome 6 between the leucocyte antigen (HLA)-B B-associated transcript genes. presence of 21-hydroxylase autoantibodies is a sensitive specific marker autoimmune Addison’s disease. We studied polymorphism exon 5 gene, intron 1 HLA-DRB1, -DQA1, -DQB1 in 28 (21-hydroxylase autoantibody positive) disease patients 75 healthy subjects from central Italy. MIC-A5.1 allele was significantly...
Patients with Addison's disease (AD) self-report impairment in specific dimensions on well-being questionnaires. An AD-specific quality-of-life questionnaire (AddiQoL) was developed to aid evaluation of patients. We aimed translate and determine construct validity, reliability, concurrent validity the AddiQoL questionnaire. After translation, final versions were tested AD patients from Norway (n = 107), Sweden 101), Italy 165), Germany 200), Poland 50). Construct examined by exploratory...
Latent autoimmune diabetes in adults (LADA) includes a heterogeneous population wherein, based on glutamic acid decarboxylase antibody (GADA) titer, different subgroups of subjects can be identified. The aim the present study was to evaluate GADA titer-related risk for β-cell and other organ-specific autoimmunity LADA subjects. Adult-onset (n = 236) type 2 (T2DM) 450) were characterized protein tyrosine phosphatase (IA-2IC IA-2256–760), zinc transporter 8 (ZnT8), thyroid peroxidase, (TPO),...
SUMMARY The diagnostic specificity of recombinant 21-hydroxylase autoantibodies (21OH-Ab) for Addison's disease was tested in adult patients with either Graves' (GD), insulin-dependent diabetes mellitus (IDDM), or polyendocrinopathy, as well healthy controls. Using a radiobinding assay vitro translated human 21-hydroxylase, we found 21OH-Ab 24/28 (86%) idiopathic Addison patients, and using an immunofluorescence adrenal cortex (ACA) 12/28 (43%) (P =0.002). All the 12 ACA-positive sera were...
To test the hypothesis that levels of adrenal autoantibodies correlate with degree dysfunction, we followed up cortex autoantibody (ACA) titers and 21-hydroxylase (21OH) (21OHAb) in 19 ACA-positive subjects preclinical Addison’s disease. On enrollment, all were positive for 21OHAb. At follow-up, concordance rate simultaneous presence/absence both ACA 21OHAb was as high 91% a strong, correlation between observed (P < 0.0001). The positively associated severity dysfunction (ANOVA, P 0.0001...
OBJECTIVE Glutamic acid decarboxylase (GAD)65 autoantibodies (GAD65Ab) in type 2 diabetic subjects with secondary failure to sulphonylurea treatment identify the so‐called latent autoimmune diabetes of adult (LADA). The aim our study was estimate risk for endocrine autoimmunity GAD65Ab. DESIGN AND PATIENTS We analysed serum samples from 600 a clinical diagnosis mellitus presence and levels GAD65Ab antibodies directed against islet autoantigen IA‐2/ICA512 (IA‐2/ICA512Ab). All patients had...
Primary adrenal insufficiency (PAI) is clinically evident in one 8000 individuals. A correct etiological classification critical for disease management. To update the diagnostic criteria of PAI, a multicentric network was established Italy, and 222 patients with PAI were studied. Both 21-hydroxylase cortex autoantibodies (21OHAb ACA, respectively) tested two independent laboratories on coded samples found 65–66% 58–61% cases, respectively. Autoimmune polyendocrine syndrome I diagnosed 11...
Objective In latent autoimmune diabetes of adults (LADA), the progression into insulin-dependent is usually faster than in type 2 (T2D) but factors influencing this are not completely known. study, we searched for sensitive markers associated with early development insulin dependence. Design The screening 5568 T2D patients glutamic acid decarboxylase autoantibodies (GAD65Ab) identified 276 LADA (M=131; F=145) and 251 them, tyrosine phosphatase-2 (IA-2Ab) thyroperoxidase (TPOAbs), some...