A5016665013- Immune Cell Function and Interaction
- Lymphoma Diagnosis and Treatment
- CAR-T cell therapy research
- Eosinophilic Esophagitis
- Acute Myeloid Leukemia Research
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Liver Disease Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Chromatin Remodeling and Cancer
- Hepatitis B Virus Studies
- Cancer Genomics and Diagnostics
- IL-33, ST2, and ILC Pathways
University of Zurich
2019-2025
German Cancer Research Center
2019-2021
Heidelberg University
2019-2021
Abstract Hepatocellular carcinoma (HCC) can have viral or non-viral causes 1–5 . Non-alcoholic steatohepatitis (NASH) is an important driver of HCC. Immunotherapy has been approved for treating HCC, but biomarker-based stratification patients optimal response to therapy unmet need 6,7 Here we report the progressive accumulation exhausted, unconventionally activated CD8 + PD1 T cells in NASH-affected livers. In preclinical models NASH-induced therapeutic immunotherapy targeted at programmed...
Abstract In the past decade, single-cell transcriptomics has helped to uncover new cell types and states led construction of a cellular compendium health disease. Despite this progress, some difficult-to-sequence cells remain absent from tissue atlases. Eosinophils—elusive granulocytes that are implicated in plethora human pathologies 1–5 —are among these uncharted types. The heterogeneity eosinophils gene programs underpin their pleiotropic functions poorly understood. Here we provide...
Article12 September 2019Open Access Source DataTransparent process The IL-6 signaling complex is a critical driver, negative prognostic factor, and therapeutic target in diffuse large B-cell lymphoma Hind Hashwah Institute of Molecular Cancer Research, University Zurich, Zürich, Switzerland Search for more papers by this author Katrin Bertram Kristin Stirm Anna Stelling Cheuk-Ting Wu Sabrina Kasser Markus G Manz Department Medical Oncology Hematology, Hospital Zurich Comprehensive Center...
Diffuse large B-cell lymphoma (DLBCL) is an aggressive malignancy arising from germinal center or post-germinal B-cells that retain many of the properties normal B-cells. Here we show a subset DLBCL express cytokine IL-10 and its receptor. The genetic ablation receptor signaling abrogates autocrine STAT3 phosphorylation triggered by tumor cell-intrinsic expression impairs growth cell lines in subcutaneous orthotopic xenotransplantation models. Furthermore, demonstrate using immunocompetent...
KMT2A-rearrangements define a subclass of acute leukemias characterized by distinct gene expression signature linked to the dysfunctional oncogenic fusion proteins arising from various chromosomal translocations involving KMT2A (also known as MLL1) gene. Research on disease pathomechanism in KMT2A-rearranged has mainly focused upregulation stemness-related genes HOX-family and their co-factor MEIS1. Here we report KMT2A::AFF1 KMT2A::MLLT3 gene-dependent downregulation SMAD1, TGF-β signaling...
SLAMF9 belongs to the conserved lymphocytic activation molecule family (SLAMF). Unlike other SLAMs, which have been extensively studied, role of in immune system remained mostly unexplored. By generating CRISPR/Cas9 knockout mice, we analyzed this receptor plasmacytoid dendritic cells (pDCs), preferentially express transcript and protein. These display a unique capacity produce type I IFN bridge between innate adaptive response. Analysis pDCs −/− mice revealed an increase immature bone...
Abstract Numerous targeted therapies have been developed for diffuse large B-cell lymphoma, but the results of late-stage clinical trials were mostly disappointing and led to very few new regulatory approvals. Here, we use single combinatorial drug response profiling show that combined inhibition anti-apoptotic protein Bcl-2 tyrosine kinase BTK with small molecules venetoclax ibrutinib efficiently kills DLBCL cells in vitro. High expression due either BCL2 amplifications or translocations,...
Background Roughly half of all diffuse large B-cell lymphomas (DLBCLs) are infiltrated by numbers regulatory T-cells (Tregs). Although the presence ‘effector’ Tregs in particular is associated with an inferior prognosis patients on standard rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) immunochemotherapy, role this cell type during lymphoma initiation progression poorly understood. Methods Here, we use tissue microarrays containing prospectively collected...
Topic: 3. Acute myeloid leukemia - Biology & Translational Research Background: Rearrangements of the Mixed Lineage Leukemia 1 (MLL1) gene in hematopoietic stem and progenitor cells cause lymphoid origin. MLL1 is a histone lysine-methyltransferase, which methylates H3K4, acts as an epigenetic expression regulator plays important role embryonic development hematopoiesis. H3K4 methylation at promotor regions associated with active transcription. Due to aberrant function protein complex...