A5010697225- Liver Disease Diagnosis and Treatment
- Diet, Metabolism, and Disease
- Hepatitis C virus research
- Liver Diseases and Immunity
- Pancreatitis Pathology and Treatment
- Diet and metabolism studies
- Diabetes and associated disorders
- Nutrition and Health in Aging
- Hepatitis B Virus Studies
- Liver Disease and Transplantation
- Drug Transport and Resistance Mechanisms
- Lipid metabolism and disorders
- Fibroblast Growth Factor Research
- Chronic Lymphocytic Leukemia Research
- Blood groups and transfusion
- Hepatocellular Carcinoma Treatment and Prognosis
- Kruppel-like factors research
- Bariatric Surgery and Outcomes
- Genetic and Kidney Cyst Diseases
- Endoplasmic Reticulum Stress and Disease
- Alcohol Consumption and Health Effects
- Cardiovascular Function and Risk Factors
- Nutritional Studies and Diet
- Systemic Sclerosis and Related Diseases
- Myeloproliferative Neoplasms: Diagnosis and Treatment
Universitätsklinikum Würzburg
2016-2025
Klinikum Würzburg Mitte
2022-2024
European Neuroendocrine Tumor Society
2023
Japan Breast Cancer Research Group
2017
University of Würzburg
2017
University Hospital of Zurich
2012-2013
Universidad de Jaén
2013
Hospital Universitario de Valme
2013
Heidelberg University
2010
Intestinal microbiota and their metabolites (e.g. short-chain fatty acids (SCFAs)) may influence nonalcoholic liver disease (NAFLD).The objective of this article is to analyze gut bacterial diversity together with fecal SCFA concentrations immunophenotyping peripheral blood in histology-proven NAFLD patients.Thirty-two patients (14 (NAFL), 18 steatohepatitis (NASH)) 27 healthy controls (HCs)) were included study. Bacterial communities feces profiled by 16S ribosomal RNA gene sequencing the...
Abstract Nonalcoholic fatty liver disease is increasing in prevalence. It can be subdivided into nonalcoholic (NAFL) and steatohepatitis (NASH). Five to twenty percent of cases progress from NAFL NASH. Increased hepatic Th17 cells IL-17 expression were observed NASH mice patients, respectively. We analyzed CD4+ effector T regulatory (Tregs) peripheral blood livers patients. A total 51 30 31 patients (without histology), 43 healthy controls included. FACS analysis was performed on PBMCs...
The PNPLA3 p.I148M, TM6SF2 p.E167K, and MBOAT7 rs641738 variants represent genetic risk factors for nonalcoholic fatty liver disease (NAFLD). Here we investigate if these polymorphisms modulate both steatosis fibrosis in patients with NAFLD. We recruited 515 NAFLD (age 16-88 years, 280 female patients). Liver biopsies were performed 320 patients. PCR-based assays used to genotype the PNPLA3, TM6SF2, variants. Carriers of alleles showed increased serum aspartate aminotransferase alanine...
The progression of non-alcoholic steatohepatitis (NASH) to fibrosis and hepatocellular carcinoma (HCC) is aggravated by auto-aggressive T cells. gut-liver axis contributes NASH, but the mechanisms involved consequences for NASH-induced liver cancer remain unknown. We investigated role gastrointestinal B cells in development HCC.
To analyze clinical manifestations, serum ferritin, and cytokine levels in patients with adult-onset Still's disease (AOSD) or bacterial sepsis to evaluate their potential use for differential diagnosis.Twenty-two consecutive the first flare of AOSD 6 an established diagnosis under immunosuppressive therapy were compared 14 sepsis. Clinical manifestations scored a Pouchot activity score including elevated ferritin obtain modified score. Serum profiles analyzed from each patient.The scores...
Liver biopsies are the current gold standard in non-alcoholic steatohepatitis (NASH) diagnosis. Their invasive nature, however, still carries an increased risk for patients' health. The development of non-invasive diagnostic tools to differentiate between bland steatosis (NAFL) and NASH remains crucial. aim this study is evaluation investigated circulating microRNAs combination with new targets order optimize discrimination patients by serum biomarkers.Serum profiles four were evaluated two...
Abstract Background & Aims There is a growing evidence that bile acids are involved in the regulation of triglyceride‐, cholesterol‐homoeostasis and fat absorption. In this study organ‐specific Fxr knockout mice were used to further investigate influence farnesoid X receptor FXR lipogenesis. Methods Liver‐ intestine‐specific fed 1% cholesterol diet for 28 days. Histological examination frozen tissue sections included Sudan III/H&E, BODIPY staining liver (LXR) immunohistochemistry....
Human iron homeostasis is regulated by intestinal transport, hepatic hepcidin release, and signals from pathways that consume or supply iron. The aim of this study was to characterize the adaptation under hypoxia in mountaineers at levels (1) (2) (3) systemic inflammatory erythropoietic responses. Twenty-five healthy were studied. Blood samples duodenal biopsies taken baseline 446 m as well on day 2 (MG2) 4 (MG4) after rapid ascent 4559 m. Divalent metal-ion transporter 1 (DMT-1),...
Current non-invasive scores for the assessment of severity non-alcoholic fatty liver disease (NAFLD) and identification patients with steatohepatitis (NASH) have insufficient performance to be included in clinical routine. In current study, we developed a novel machine learning approach overcome caveats existing approaches.Non-invasive parameters were selected by an ensemble feature selection (EFS) from retrospectively collected training cohort 164 obese individuals (age: 43.5±10.3y; BMI:...
Atezolizumab/bevacizumab (atezo/bev) and lenvatinib have demonstrated efficacy as first-line therapies for hepatocellular carcinoma (HCC). However, vascular endothelial growth factor (VEGF) inhibition with these may be associated the risk of bleeding thromboembolic events. In this study, we evaluated safety focus on events atezo/bev
Abstract The circadian clock plays a crucial role in regulating the timing of numerous physiological processes. Its dysregulation has severe implications for organism’s homeostasis and is among main characteristics aging. As women age transition through menopause, disruptions rhythms may occur, leading to symptoms such as insomnia, mood changes, or altered energy levels. In this prospective non-randomized cohort study, we seek characterize better understand alterations across various stages...