A5090877861- Cytokine Signaling Pathways and Interactions
- Genetic factors in colorectal cancer
- RNA Research and Splicing
- interferon and immune responses
- Monoclonal and Polyclonal Antibodies Research
- Hippo pathway signaling and YAP/TAZ
- Cancer Cells and Metastasis
- Reproductive System and Pregnancy
- Endometrial and Cervical Cancer Treatments
- Tuberculosis Research and Epidemiology
- Biochemical and Molecular Research
- Immune Cell Function and Interaction
- TGF-β signaling in diseases
- Cancer Genomics and Diagnostics
- Metastasis and carcinoma case studies
- Mechanisms of cancer metastasis
- Research on Leishmaniasis Studies
- Mast cells and histamine
- Chronic Lymphocytic Leukemia Research
- Estrogen and related hormone effects
- Immunotherapy and Immune Responses
- Ovarian cancer diagnosis and treatment
- Pneumocystis jirovecii pneumonia detection and treatment
- FOXO transcription factor regulation
- Neuroblastoma Research and Treatments
Karolinska Institutet
2011-2023
Science for Life Laboratory
2018-2022
Svenska Örtmedicinska Institute
2019
Uppsala University
2017
Karolinska University Hospital
2014
Redox regulation of STAT3 is targeted by direct inhibition TrxR1, illuminating a promising link for therapeutic development.
Cancer is often characterized by aberrant gene expression patterns caused the inappropriate activation of transcription factors. Signal transducer and activator 3 (STAT3) a key transcriptional regulator many protumorigenic processes persistently activated in types human cancer. However, like factors, STAT3 has proven difficult to target clinically. To address this unmet clinical need, we previously developed cell-based assay activity performed an unbiased high-throughput screen small...
// Ananya Roy 1, 6, Sanaz Attarha 1 , Holger Weishaupt Per-Henrik Edqvist 2 Fredrik J. Swartling Michael Bergqvist 3 Florian A. Siebzehnrubl 4 Anja Smits 5, 7 Pontén Elena Tchougounova Uppsala University, Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala, Sweden Science for Life Umeå Radiation Sciences, Umeå, Cardiff University School Biosciences, European Cancer Stem Cell Research Institute, Cardiff, United Kingdom 5 Neuroscience, Neurology, 6 Swedish...
In this study, we used proteomics and biological network analysis to evaluate the potential processes components present in identified proteins of biopsies from cutaneous leishmaniasis (CL) patients infected by Leishmania braziliensis comparison with normal skin. We 59 differently expressed samples Biological employing showed presence networks that may be involved cell death mediated cytotoxic T lymphocytes. After immunohistochemical analyses, expression caspase-9, caspase-3, granzyme B was...
Abstract Prokineticin 1 (PROK1), a hypoxia‐regulated angiogenic factor, has emerged as crucial regulator of embryo implantation and placentation. Dysregulation PROK1 been linked to recurrent pregnancy loss, pre‐eclampsia, foetal growth restriction preterm birth. These complications are common in women with obesity polycystic ovary syndrome, i.e. conditions associated insulin resistance compensatory hyperinsulinaemia. We investigated the effect on expression during vitro decidualization....
Cervical cancer is the second most prevalent malignancy among women worldwide, and additional objective diagnostic markers for this disease are needed. Given link between development alternative splicing, we aimed to analyze splicing patterns of PRDX2, RAB1A, RAB1B, RAB5A RAB25 genes, which associated with different cancers, in normal cervical tissue, preinvasive lesions invasive tumors, identify new markers. Biopsies were subjected rapid amplification cDNA 3' ends (3' RACE) RT‑PCR....
Signal transducer and activator of transcription (STAT) proteins have important biological functions; however, deregulation STAT signaling is a driving force behind the onset progression inflammatory diseases cancer. While their roles suggest that would be valuable targets for developing therapeutic agents, are notoriously difficult to inhibit using small drug-like molecules, as they do not distinct inhibitor binding site. Despite this, multitude small-molecule inhibitors been proposed,...
The individual features of tumours are often disregarded in cohort studies. As these may represent a source for individualised cancer treatment, it is important to develop novel approach their assessment. We used proteomics, systems biology, and immunohistochemistry explore protein expression human endometrial tumours, identify deregulated regulatory mechanisms, validate observed changes using tissue microarrays. Compared with the evaluation common tumour features, gave more comprehensive...
Transforming growth factor-β (TGFβ) and epidermal factor (EGF) are two potent regulators of tumorigenesis. Signaling cross-talk TGFβ EGF employs a number which define the impact on cell physiology. MST1 has recently been reported as regulator tumorigenesis differentiation. To investigate role mammalian sterile-like 1 (MST1) in signaling, we established transiently MST1‑transfected HEC-1-A endometrial cancer cells, subjected cells to treatment with TGFβ1, their combination. We report negative...
The response of cells to TGFβ and EGF is mediated by a network various intracellular regulators. signaling crosstalk between different regulators key importance for tumorigenesis. may explain the modulation cellular responses same regulator another molecule. As PKN1 - serine/threonine kinase implicated in tumorigenesis was identified as potential node signaling, functions that be affected were explored.To investigate contribution transiently PKN1-transfected HEC-1-A endometrial cancer...
Abstract Cancer is often characterized by aberrant gene expression patterns that alter cellular function. Such alterations are commonly caused the inappropriate activation of transcription factors. STAT3, in particular, a key transcriptional regulator many pro-tumorigenic processes, including inflammation, proliferation, and survival, persistently phosphorylated activated more than 70% breast tumors. Accordingly, it promising therapeutic target for treatment cancer. However, like factors,...
Cancer is often characterized by aberrant gene expression patterns that alter cellular function. Such alterations are commonly caused the inappropriate activation of transcription factors. STAT3, in particular, a key transcriptional regulator many pro-tumorigenic processes, including inflammation, proliferation, and survival, persistently phosphorylated activated more than 70% breast tumors. Accordingly, it promising therapeutic target for treatment cancer. However, like factors, STAT3 has...
In a previous study, we showed that serine/threonine-protein kinase 4 (STK4) is involved in the control on proliferation and migration of endometrial cancer (EC) cells vitro. present paper, studied STK4 expression EC tissues from large cohort patients to determine whether can serve as marker for aggressiveness prognosis EC. Tissue samples with were examined tumor type, grade, stage. The protein was assessed by immunohistochemistry related clinicopathological data patients, such progression...
Several markers of survival among endometrial cancer (EC) patients have been proposed, namely, the oncoprotein stathmin, RAF kinase inhibitor (RKIP), Cyclin A, GATA-binding protein 3 (GATA3), and growth differentiation factor-15 (GDF-15). Their elevated expression correlated significantly with a high stage, serous papillary/clear cell subtypes, aneuploidy. In previous study, we reported serine/threonine N1 (PKN1) in cancerous cells. present paper, studied PKN1 EC tissues from large cohort...