A5071539952- Endometriosis Research and Treatment
- Reproductive System and Pregnancy
- Pregnancy and preeclampsia studies
- Ovarian function and disorders
- Ectopic Pregnancy Diagnosis and Management
- Endometrial and Cervical Cancer Treatments
- Uterine Myomas and Treatments
- Reproductive Biology and Fertility
- Pregnancy-related medical research
- Menstrual Health and Disorders
Karolinska University Hospital
2017-2023
Karolinska Institutet
2017-2023
Insulin resistance and compensatory hyperinsulinemia are characteristic features of obesity polycystic ovary syndrome, both associated with reduced fertility implantation. There is little knowledge about the effect insulin on decidualization process previous findings contradictory. We investigated regulation forkhead box protein O1 (FOXO1), one most important transcription factors during decidualization. Endometrial stromal cells were isolated from six healthy, regularly menstruating women...
Summary Objective Lifestyle intervention is the recommended first‐line treatment for overweight women with polycystic ovary syndrome (PCOS). However, efficacy of lifestyle change in improving reproductive function still unclear. Design A randomized controlled trial (RCT) allocation to a behavioural modification programme (intervention) or minimal (control) 4 months follow‐up at 12 months. Patients Sixty‐eight women, aged 18‐40 years, body mass index (BMI) ≥ 27 kg/m 2 , fulfilling all...
Endometriosis is largely considered a premenopausal disease with symptoms often improving during menopausal transition. However, 2%-4% of postmenopausal women are affected by endometriosis symptoms. At the same time, many peri- and experience inquire about treatment. Because estrogen-dependent nature endometriosis, treatment hormone therapy requires careful assessment patient but should nevertheless be considered. Recurrence risk for malignant transformation potential risks to weigh when...
Abstract Prokineticin 1 (PROK1), a hypoxia‐regulated angiogenic factor, has emerged as crucial regulator of embryo implantation and placentation. Dysregulation PROK1 been linked to recurrent pregnancy loss, pre‐eclampsia, foetal growth restriction preterm birth. These complications are common in women with obesity polycystic ovary syndrome, i.e. conditions associated insulin resistance compensatory hyperinsulinaemia. We investigated the effect on expression during vitro decidualization....
Abstract Finely tuned decidualization of endometrial stromal fibroblasts into decidual cells is crucial for successful implantation and a healthy pregnancy. Both insulin androgens are known to modulate decidualization, however, their complex effect on this process has not been fully elucidated. As hyperinsulinemia hyperandrogenism associated in clinical conditions, we aimed investigate the interaction between decidualization. Primary human were decidualized vitro presence and/or...
Solute carrier family 2 member 1 (SLC2A1; previously known as glucose transporter 1), is the most abundant in human endometrium and up-regulated during decidualization, whereas high insulin may have a negative impact on this process. The present study aimed to investigate effect of expression SLC2A1 uptake decidualizing endometrial stromal cells.We induced vitro decidualization cells obtained from regularly menstruating healthy non-obese women. were treated with increasing concentrations...