A5086812710- Food Allergy and Anaphylaxis Research
- Allergic Rhinitis and Sensitization
- Lymphatic System and Diseases
- Monoclonal and Polyclonal Antibodies Research
- Prostate Cancer Treatment and Research
- Cancer Cells and Metastasis
- Estrogen and related hormone effects
- Angiogenesis and VEGF in Cancer
- Cancer, Lipids, and Metabolism
- Cytokine Signaling Pathways and Interactions
- Advanced Proteomics Techniques and Applications
- T-cell and B-cell Immunology
- Asthma and respiratory diseases
- Transgenic Plants and Applications
- Wnt/β-catenin signaling in development and cancer
- Advanced Biosensing Techniques and Applications
- PI3K/AKT/mTOR signaling in cancer
- Glycosylation and Glycoproteins Research
- vaccines and immunoinformatics approaches
- Pressure Ulcer Prevention and Management
- Hedgehog Signaling Pathway Studies
- Thyroid Cancer Diagnosis and Treatment
- Toxin Mechanisms and Immunotoxins
- Thyroid Disorders and Treatments
- Growth Hormone and Insulin-like Growth Factors
Medical University of Vienna
2011-2024
Comprehensive Cancer Center Vienna
2024
Center For Biomarker Research In Medicine
2022
Institute of Clinical Research
2009
University of Vienna
2008
Research Institute of General Pathology and Pathophysiology, the Russian Academy of Medical Sciences
2004
In individuals with mammary carcinoma, the most relevant prognostic predictor of distant organ metastasis and clinical outcome is status axillary lymph node metastasis. Metastases form initially in sentinel nodes progress via connecting lymphatic vessels into postsentinel nodes. However, mechanisms consecutive colonization are unknown. Through analysis human carcinomas their matching nodes, we show here that intrametastatic bulk tumor cell invasion these highly correlate formation an vitro...
Abstract Prostate cancer (PCa) is a common and fatal type of in men. Metastatic PCa (mPCa) major factor contributing to its lethality, although the mechanisms remain poorly understood. PTEN one most frequently deleted genes mPCa. Here we show frequent genomic co-deletion STAT3 liquid biopsies patients with Loss Stat3 Pten -null mouse prostate model leads reduction LKB1/pAMPK simultaneous activation mTOR/CREB, resulting metastatic disease. However, constitutive led high levels suppressed...
Prostate cancer (PCa) has a broad spectrum of clinical behavior; hence, biomarkers are urgently needed for risk stratification. Here, we aim to find potential stratification, by utilizing gene co-expression network transcriptomics data in addition laser-microdissected proteomics from human and murine prostate FFPE samples. We show up-regulation oxidative phosphorylation (OXPHOS) PCa on the transcriptomic level TCA cycle/OXPHOS proteomic level, which is inversely correlated STAT3 expression....
Abstract In type I allergy, the cross-linking of membrane IgE on B lymphocytes and cytophilic effector cells by their respective allergens are key events. For two molecules, need at least epitopes. On large these could be different epitopes in a multivalent, or identical symmetrical, fashion. However, availability may limited small such as Bet v 1, major birch pollen allergen. The present work analyzes whether dimerization is required for capacity this immunoblots, murine monoclonal...
The intravasation of breast cancer into the lymphendothelium is an early step metastasis. Little known about mechanisms bulky invasion lymph ducts.
Thyroid hormone (TH) signaling plays a major role in the development, energy homeostasis, and metabolism of most tissues. Recent observations have identified THs as drivers prostate cancer (PCa) tumor development progression. We reported that T3-scavenger protein μ-crystallin (CRYM) regulates progression PCa this involved crosstalk with androgen receptor (AR) signaling. However, mechanisms remain incompletely understood. Here, we explored thyroid β (TRβ), which is main effector TH signaling,...
Systemic lupus erythematosus (SLE) is a complex autoimmune disease affecting various tissues. Involvement of B and T cells as well increased cytokine levels have been associated with manifestation. Recently, we demonstrated that mice epidermal loss JunB (JunB(Deltaep)) develop myeloproliferative syndrome (MPS) due to high G-CSF which are secreted by JunB-deficient keratinocytes. In addition, show JunB(Deltaep) SLE phenotype linked interleukin 6 (IL-6) secretion. Intercrosses IL-6-deficient...
Podoplanin is a membrane mucin that, among series of tissues, expressed on late osteoblasts and osteocytes. Since recent findings have focussed podoplanin's potential role as tumour progression factor, we aimed at identifying regulatory elements conferring PDPN promoter activity. Here, characterized the molecular mechanism controlling basal transcription in human osteoblast-like MG63 versus Saos-2 cells. We cloned sequenced 2056 nucleotides from 5'-flanking region gene computational search...
Type 2 diabetes is associated with microvascular damage that causes frequent infections in the skin and chronic ulcers as a result of impaired wound healing. To trace pathological changes, we performed comprehensive analysis lymphatic vessels type diabetic versus nondiabetic patients. The dermis revealed enhanced vessel density, transcriptional profiling ex vivo isolated endothelial cells (LECs) identified 160 genes differentially expressed between LECs. Bioinformatic deregulated uncovered...
Xylosylated and core α1,3-fucosylated N-glycans from plants are immunogenic, they play a still obscure role in allergy the field of plant-made protein pharmaceuticals. We immunized mice to generate monoclonal antibodies (mAbs) binding plant specifically via epitope containing either xylose or α1,3-fucose residue. Splenocytes expressing N-glycan-specific derived C57BL/6 previously with glycoproteins were preselected by cell sorting hybridoma lines producing specific antibodies. However, we...
The identification of marker molecules specific for blood and lymphatic endothelium may provide new diagnostic tools identify targets therapy immune, microvascular cancerous diseases. Here, we used a phage display library expressing human randomized single-chain Fv (scFv) antibodies direct panning against live cultures (BECs) (LECs) endothelial cells in solution. After six rounds, out 944 sequenced antibody clones, retrieved 166 unique/diverse scFv fragments, as indicated by the V-region...
We aimed to identify novel markers for aggressive prostate cancer in a STAT3-low proteomics-derived dataset of mitochondrial proteins by immunohistochemical analysis and correlation with transcriptomic data biochemical recurrence STAT3 independent PCa cohort. Formalin-fixed paraffin-embedded tissue (FFPE) sample selection proteomic tissue-microarray (TMA) generation was conducted from cohort patients. Retrospective performed the same 153 differentially expressed between STAT3-high samples...
The nuclear hormone family of receptors regulates gene expression. androgen receptor (AR) shuttles upon ligand binding and homodimerization from the cytosol into nucleus to activate Thyroid receptors(TR), retinoic acid (RAR), vitamin D (VDR) are present in bound chromatin as a heterodimer with retinoid X (RXR) repress Ligand leads transcription activation. hormonal ligands for these play crucial roles ensure proper conduct very many tissues exert effects on prostate cancer (PCa) cells....