A5091989012- Cardiac Arrhythmias and Treatments
- Cardiac electrophysiology and arrhythmias
- Advanced MRI Techniques and Applications
- Cardiac Imaging and Diagnostics
- Cardiac pacing and defibrillation studies
- 3D Printing in Biomedical Research
- Cardiovascular Function and Risk Factors
- Atrial Fibrillation Management and Outcomes
- Neuroscience and Neural Engineering
- Photoreceptor and optogenetics research
Spanish National Centre for Cardiovascular Research
2023-2024
Abstract Electromechanical characterization during atrial fibrillation (AF) remains a significant gap in the understanding of AF-related myopathy. This study reports mechanistic insights into electromechanical remodeling process associated with AF progression and further demonstrates its prognostic value clinic. In pigs, sequential assessment shows progressive decrease mechanical activity early dissociation from electrical counterpart. Atrial tissue samples animals reveal an abnormal...
There is lack of agreement on late gadolinium enhancement cardiac magnetic resonance (LGE-CMR) imaging processing for guiding ventricular tachycardia (VT) ablation. We aim at developing and validating a systematic approach LGE-CMR images to identify VT corridors that contain critical isthmus sites.
Abstract Introduction In the clinic, complete characterization of reentrant ventricular tachycardia (VT) circuits using classical electrophysiological criteria and state-of-the-art high density mapping during VT is complex, often cannot be completed because hemodynamic instability. This common limitation has motivated implementation strategies sinus rhythm or pacing aiming to identify scar regions associated with isthmuses potential arrhythmogenicity. Complementary imaging-based including...
Electrophysiological characterization of ventricular tachycardia (VT) isthmus sites is complex and time-consuming. We aimed at developing validating a global mapping strategy during programmed stimulation (PVS) to reveal the underlying electrophysiological properties infarct-related substrate enable identification highly heterogeneous activation associated with protected VT sites.
Scalable and high-throughput electrophysiological measurement systems are necessary to accelerate the elucidation of cardiac diseases in drug development. Optical mapping is primary method simultaneously measuring several key parameters, such as action potentials, intracellular free calcium conduction velocity, at high spatiotemporal resolution. This tool has been applied isolated whole-hearts, whole-hearts in-vivo, tissue-slices monolayers/tissue-constructs. Although optical all these...
Abstract Background Structural remodeling in the context of persistent atrial fibrillation (PAF) has been mainly characterized by imaging techniques focused on fibrosis detection. Diffusion tensor (DTI) demonstrated its direct relationship with histological properties and myocyte organization, which may provide a more complete structural information. However, potential DTI characterization AF-related substrate remains unknown. Purposes To evaluate performance DTI-derived parameters to...