A5079169566- Cardiac Imaging and Diagnostics
- Advanced MRI Techniques and Applications
- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Cardiac electrophysiology and arrhythmias
- Cardiovascular Health and Disease Prevention
- Cardiovascular Function and Risk Factors
- Cardiovascular Effects of Exercise
- Medical Imaging Techniques and Applications
- Cardiac pacing and defibrillation studies
- Cerebrovascular and Carotid Artery Diseases
- Coronary Interventions and Diagnostics
- Radiation Dose and Imaging
- Acute Ischemic Stroke Management
- MRI in cancer diagnosis
- Cardiac Valve Diseases and Treatments
- Atomic and Subatomic Physics Research
- Ultrasound and Hyperthermia Applications
- Elasticity and Material Modeling
- Advanced X-ray and CT Imaging
- Advanced Neuroimaging Techniques and Applications
- Cardiac Structural Anomalies and Repair
- Radiomics and Machine Learning in Medical Imaging
- Adrenal and Paraganglionic Tumors
- Tribology and Lubrication Engineering
Maastricht University
2015-2025
Maastricht University Medical Centre
2016-2025
King's College London
2016-2025
University of Lausanne
2024-2025
St Thomas' Hospital
2024-2025
University Medical Center
2021-2024
Délégation Provence et Corse
2021
Cardiovascular Institute Hospital
2020-2021
Dark-blood late gadolinium enhancement (LGE) has been shown to improve the visualization and quantification of areas ischemic scar compared standard bright-blood LGE. Recently, performance various semi-automated methods evaluated for assessment infarct size using both dark-blood LGE conventional with histopathology as a reference standard. However, impact this sequence on different strategies in vivo remains uncertain. In study, were range non-ischemic pathologies encountered clinical...
This study evaluates a novel dark-blood late gadolinium enhancement (LGE) cardiovascular magnetic resonance imaging (CMR) method, without using additional magnetization preparation, and compares it to conventional bright-blood LGE, for the detection of ischaemic myocardial scar. LGE is able clearly depict infarction macroscopic scarring from viable myocardium. However, due bright signal adjacent left ventricular blood, apparent volume scar tissue can be significantly reduced, or even...
For two decades, bright-blood late gadolinium enhancement (LGE) cardiovascular magnetic resonance (CMR) has been considered the reference standard for non-invasive assessment of myocardial viability. While LGE can clearly distinguish areas infarction from viable myocardium, it often suffers poor scar-to-blood contrast, making subendocardial scar difficult to detect. Recently, we proposed a novel dark-blood approach that increases contrast and thereby improves conspicuity. In present study...
Cardiovascular magnetic resonance (CMR) is the gold standard for assessing cardiac volumes and function using 2D breath-held cine imaging. This technique, however, requires a reliable ECG signal, repetitive breath-holds, time-consuming proficiency-demanding planning of views. Recently, free-running framework has been developed respiratory motion-resolved 5D whole-heart imaging without need an meticulous plan scanning. In this study, we investigate impact acquisition time on volumetric...
This study aimed to evaluate the influence of reader training and experience on detection (small) myocardial infarctions (MIs) assessment ischemic scar transmurality using dark-blood late gadolinium enhancement (LGE) bright-blood LGE magnetic resonance imaging. It was hypothesized that simplifies MIs for less experienced readers, compared with One hundred patients referred cardiac imaging suspected were retrospectively included. Dark-blood performed first, followed by LGE. Nine clinicians,...
Continuous progress in atrial fibrillation (AF) ablation techniques has led to an increasing number of procedures with improved outcome. However, about 30-50% patients still experience recurrences within 1 year after their ablation. Comprehensive translational research approaches integrated clinical care pathways may improve our understanding the complex pathophysiology AF and patient selection for ablation.Within "IntenSive mOlecular eLectropathological chAracterization patienTs undergoIng...
Abstract Background The potential role of cardiac computed tomography (CT) has increasingly been demonstrated for the assessment diffuse myocardial fibrosis through quantification extracellular volume (ECV). Photon-counting detector (PCD)-CT technology may deliver more accurate ECV compared to energy-integrating CT. We evaluated impact reconstruction settings on accuracy using PCD-CT, with magnetic resonance imaging (MRI)-based as reference. Methods In this post hoc analysis, 27 patients...
Introduction: Microvascular rarefaction, the functional reduction in perfused microvessels and structural of microvascular density, seems to be an important mechanism pathophysiology small blood vessel-related disorders including vascular cognitive impairment (VCI) due cerebral vessel disease heart failure with preserved ejection fraction (HFpEF). Both diseases share common risk factors hypertension, diabetes mellitus, obesity, ageing; turn, these comorbidities are associated rarefaction....
Conventional bright-blood late gadolinium enhancement (LGE) cardiac magnetic resonance imaging (MRI) often suffers from poor scar-to-blood contrast due to the bright blood pool adjacent enhanced scar tissue. Recently, a dark-blood LGE method was developed which increases without using additional magnetization preparation.We aim histopathologically validate this in porcine animal model with induced myocardial infarction (MI).Prospective.Thirteen female Yorkshire pigs.1.5 T, two-dimensional...
Abstract Purpose A 2D image navigator (iNAV) based 3D whole-heart sequence has been used to perform MRI and PET non-rigid respiratory motion correction for hybrid PET/MRI. However, only the data acquired during acquisition of is corrected motion. This study introduces evaluates an MRI-based method complete data. Methods Twelve oncology patients scheduled additional cardiac 18 F-Fluorodeoxyglucose ( F-FDG) PET/MRI 15 with coronary artery disease (CAD) F-Choline F-FCH) were included. iNAV...
Objectives Dark-blood late gadolinium enhancement (DB-LGE) cardiac magnetic resonance has been proposed as an alternative to standard white-blood LGE (WB-LGE) imaging protocols enhance scar-to-blood contrast without compromising scar-to-myocardium contrast. In practice, both DB and WB contrasts may have clinical utility, but acquiring the drawback of additional acquisition time. The aim this study was develop evaluate a deep learning method generate synthetic WB-LGE images from DB-LGE,...
Fifty consecutive patients with previous cardiac arrhythmias, scheduled for high-resolution 3D LGE MRI, were prospectively enrolled between October 2017 and February 2020. Free-breathing dark-blood MRI high isotropic resolution (1.6 × 1.6 mm) was performed using a conventional fixed TI (n = 25) or dynamic 25). The average increase in blood nulling per minute obtained from Look-Locker scans before after the acquisition first group. This increment used as input to calculate of initial value...
To evaluate the performance of various semi-automated techniques for quantification myocardial infarct size on both conventional bright-blood and novel dark-blood late gadolinium enhancement (LGE) images using histopathology as reference standard.In 13 Yorkshire pigs, reperfused infarction was experimentally induced. At 7 weeks post-infarction, LGE imaging were performed a 1.5 T magnetic resonance scanner. Following (MRI), animals sacrificed, obtained. The percentage infarcted myocardium...
Introduction: During ultrasound distensibility assessment of the carotid artery, patient's head is usually rotated sideward and slightly upward to optimize visibility segment. Head rotation may affect vessel length thus longitudinal strain arterial Because circumferential mechanical behaviour an artery are intrinsically related, influence mechanics thereby measured distensibility. Methods: In 12 apparently healthy volunteers (age 22 ± 3 years, mean SD, 6 men/6 women), we investigated whether...
Abstract Aims To illustrate the practical and technical challenges along with safety aspects when performing MRI‐guided electrophysiological procedures in a pre‐existing diagnostic magnetic resonance imaging (MRI) environment. Methods Results A dedicated, well‐trained multidisciplinary interventional cardiac MRI team (iCMR team), consisting of electrophysiologists, cardiologists, radiologists, anaesthesiologists, physicists, (EP) technicians, biomedical engineers, medical instrumentation...