A5087261955- Cerebrovascular and Carotid Artery Diseases
- Acute Ischemic Stroke Management
- Cardiac Imaging and Diagnostics
- Medical Imaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Cardiovascular Health and Disease Prevention
- Advanced X-ray and CT Imaging
- Coronary Interventions and Diagnostics
- Radiomics and Machine Learning in Medical Imaging
- Parathyroid Disorders and Treatments
- MRI in cancer diagnosis
Maastricht University
2020-2025
University Medical Center
2022-2024
The Plaque at RISK (PARISK) study demonstrated that patients with a carotid plaque intraplaque hemorrhage (IPH) have an increased risk of recurrent ipsilateral ischemic cerebrovascular events. It was previously reported symptomatic plaques IPH showed higher signal intensity ratios (SIR) and larger volumes than asymptomatic plaques. We explored whether SIR volume are associated future events beyond the presence IPH. TIA stroke mild-to-moderate stenosis IPH-positive (n=89) from PARISK were...
Objectives Carotid plaque vulnerability is a strong predictor of recurrent ipsilateral stroke, but differentiation components using conventional computed tomography (CT) suboptimal. The aim our study was to evaluate the ability dual-energy CT (DECT) characterize atherosclerotic carotid based on effective atomic number and electron density magnetic resonance imaging (MRI) and, where possible, histology as reference standard. Materials Methods Patients with recent cerebral ischemia ≥2-mm...
Abstract Purpose A 2D image navigator (iNAV) based 3D whole-heart sequence has been used to perform MRI and PET non-rigid respiratory motion correction for hybrid PET/MRI. However, only the data acquired during acquisition of is corrected motion. This study introduces evaluates an MRI-based method complete data. Methods Twelve oncology patients scheduled additional cardiac 18 F-Fluorodeoxyglucose ( F-FDG) PET/MRI 15 with coronary artery disease (CAD) F-Choline F-FCH) were included. iNAV...
<h3>BACKGROUND AND PURPOSE:</h3> Intraplaque hemorrhage contributes to lipid core enlargement and plaque progression, leading destabilization stroke. The mechanisms that contribute the development of intraplaque are not completely understood. A higher incidence thin/ruptured fibrous cap (upstream maximum stenosis in patients with severe [≥70%] carotid stenosis) has been reported. We aimed noninvasively study distribution a mild-to-moderate stenosis. <h3>MATERIALS METHODS:</h3> Eighty-eight...
Carotid atherosclerotic plaques with a large lipid-rich necrotic core (LRNC), intraplaque hemorrhage (IPH), and thin or ruptured fibrous cap are associated increased stroke risk. Multi-sequence MRI can be used to quantify carotid plaque composition. Yet, its clinical implementation is hampered by long scan times image misregistration. Multi-contrast atherosclerosis characterization (MATCH) overcomes these limitations. This study aims compare the quantification of composition MATCH...
<title>Abstract</title> <italic>Purpose</italic> <sup>18</sup>F-fluorocholine is a positron emission tomography (PET) tracer earlier found to be marker of macrophage content in carotid plaques. We aimed assess the feasibility <sup>18</sup>F-choline PET-MRI non-invasively localize vulnerable coronary plaques, using optical coherence (OCT) as reference standard. <italic>Methods</italic> Patients with recent myocardial infarction who were scheduled for secondary angiography non-culprit vessel,...
Motivation: The presence of intraplaque hemorrhage (IPH) is a strong independent stroke predictor. Higher IPH signal intensity ratios (SIR) and volumes were found in symptomatic versus asymptomatic carotid arteries. Goal(s): To determine if SIR volume are associated with the risk for ipsilateral ischemic neurovascular events patients &lt;70% stenosis. Approach: Cox proportional hazards logistic regression used to explore association 87 IPH-positive patients. Results: not during...
Carotid radiofrequency coils inside a PET/MRI system can result in PET quantification errors. We compared the performance of dedicated carotid coil against for MRI-only use. An 18F-fluorodeoxyglucose (18F-FDG) phantom was scanned without and with an coil. The decay-corrected normalized activity different configurations. Eighteen patients were three maximal standardized uptake values (SUVmax) signal-to-noise ratios (SNR) calculated. Repeated measures ANOVA performed to assess differences...