A5045680779- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular Health and Disease Prevention
- Acute Ischemic Stroke Management
- Intracranial Aneurysms: Treatment and Complications
- Cardiac Imaging and Diagnostics
- Intracerebral and Subarachnoid Hemorrhage Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Protein Tyrosine Phosphatases
- Cardiovascular Disease and Adiposity
- Parathyroid Disorders and Treatments
- Brain Tumor Detection and Classification
- Advanced Neuroimaging Techniques and Applications
- Caveolin-1 and cellular processes
- Dermatological and Skeletal Disorders
- Thyroid Cancer Diagnosis and Treatment
- Health, Environment, Cognitive Aging
- Protease and Inhibitor Mechanisms
University Medical Center Utrecht
2019-2024
Utrecht University
2020-2024
IMT School for Advanced Studies Lucca
2018
Lipoprotein(a) is an independent risk factor for cardiovascular disease and recurrent ischemic stroke. levels are known to be associated with carotid artery stenosis, but the relation of lipoprotein(a) atherosclerotic plaque composition morphology less known. We hypothesize that higher lipoprotein(a)-related SNPs a more vulnerable this effect sex-specific.In 182 patients Plaque At RISK study we determined concentrations, apo(a) KIV-2 repeats LPA SNPs. Imaging characteristics atherosclerosis...
Background and Purpose— Aneurysmal subarachnoid hemorrhage (aSAH) may have detrimental effects on white matter microstructure, which in turn explain the cognitive impairments that occur often after aSAH. We investigated (1) whether microstructure is altered patients with aSAH compared an unruptured intracranial aneurysm (2) these abnormalities are associated impairment 3 months ictus. Methods— Forty-nine 22 underwent 3T brain magnetic resonance imaging, including a high-resolution diffusion...
<h3>BACKGROUND AND PURPOSE:</h3> Intraplaque hemorrhage contributes to lipid core enlargement and plaque progression, leading destabilization stroke. The mechanisms that contribute the development of intraplaque are not completely understood. A higher incidence thin/ruptured fibrous cap (upstream maximum stenosis in patients with severe [≥70%] carotid stenosis) has been reported. We aimed noninvasively study distribution a mild-to-moderate stenosis. <h3>MATERIALS METHODS:</h3> Eighty-eight...
<h3>Background and Objective</h3> To investigate the association of silent vascular lesions, imaging negative ischemia, symptomatic cerebrovascular disease with long-term progression brain atrophy lesions in patients arterial disease. <h3>Methods</h3> Within Second Manifestations Arterial Disease–Magnetic Resonance (SMART-MR) study, stroke status participants at baseline was classified as no (reference group, n = 829), (n 206), lesion 157), imaging-negative ischemia 90) according to clinical...
Carotid atherosclerotic intraplaque hemorrhage (IPH) predicts stroke. Patients with a history of stroke are treated antiplatelet agents to prevent secondary cardiovascular events. A positive association between previous use and IPH was reported in cross-sectional analysis. We investigated the changes over 2 years patients who recently started versus those continued use.
<b><i>Introduction:</i></b> Calcifications of the intracranial internal carotid artery (iICA) can lead to an increased risk for stroke. Two types iICA calcification are known: those affecting tunica intima or media. In extracranial arteries, factors and patterns different in women men, but little is known regarding iICA. this study, we aimed identify sex-specific profiles medications associated intimal medial patients with cardiovascular disease (CVD)....
Background and purpose Arterial calcifications on unenhanced CT scans vessel wall lesions MRI are often used interchangeably to portray intracranial arterial disease. However, the extent of pathology depicted with each technique is unclear. We investigated presence distribution these two imaging findings in patients a history cerebrovascular Materials methods analyzed data from 78 admitted for stroke or TIA at our institution. Vessel were assessed 7 T sequences, while scans. The number...
Pseudoxanthoma elasticum (PXE) is a genetic disorder characterized by systemic calcification of elastin fibers. Additionally, PXE associated with an increased risk stroke. It has been hypothesized that this may be caused accelerated (intracranial) atherogenesis, as consequence specific mutations underlying PXE. Hence, we compared the distribution and burden intracranial atherosclerosis between patients healthy controls.Fifty 40 age-and-sex-matched controls (without previous ischemic...
Background: Diagnosis of cerebrovascular disease is based on both clinical and radiological findings, however, they do not always correlate. Aims: To investigate ischemic stroke recurrence mortality in patients with different imaging phenotypes disease. Methods: Within the SMART-MR study, a prospective patient cohort arterial disease, diseases participants at baseline were classified as no (reference group, n = 828), symptomatic ( 204), covert vascular lesions 156), or negative ischemia 90)...
Hippocampal calcification is a recently described type of intracranial and might be risk factor for ischemic stroke dementia. Data on its factors insight into the etiology are limited. We aimed to investigate association hippocampal in two independent cohorts Netherlands. Unenhanced CT scans brain were scored presence severity prospectively collected patient cohorts, first consisting aneurysmal subarachnoid hemorrhage (SAH) patients (N = 741) second participating Second Manifestation...