A5065276360- Advanced MRI Techniques and Applications
- Medical Imaging Techniques and Applications
- Wound Healing and Treatments
- Atomic and Subatomic Physics Research
- Cervical Cancer and HPV Research
- Cardiac electrophysiology and arrhythmias
- Endometrial and Cervical Cancer Treatments
- Uterine Myomas and Treatments
- Endometriosis Research and Treatment
- Congenital Heart Disease Studies
- Cardiac Imaging and Diagnostics
- Cardiac Valve Diseases and Treatments
- Mesenchymal stem cell research
- Medical and Health Sciences Research
- Sarcoidosis and Beryllium Toxicity Research
- Diabetic Foot Ulcer Assessment and Management
- Congenital Diaphragmatic Hernia Studies
- Periodontal Regeneration and Treatments
- Neutropenia and Cancer Infections
- Ultrasound Imaging and Elastography
- Body Contouring and Surgery
- Lymphatic Disorders and Treatments
- Maternal and fetal healthcare
- MRI in cancer diagnosis
- School Health and Nursing Education
King's College London
2017-2024
St Thomas' Hospital
2023
Ludwig-Maximilians-Universität München
1986-2022
Guy's Hospital
2017
Heidelberg University
2013
University Hospital Heidelberg
2013
Witten/Herdecke University
2010-2013
Hôpital Arnaud de Villeneuve
2011
Franklin University
2005-2006
Charité - Universitätsmedizin Berlin
2005-2006
Objectives— Fetal magnetocardiography (FMCG), a new non-invasive diagnostic tool in the analysis of electrophysiological changes heart, was selectively applied cases fetal arrhythmias and congenital heart defect (CHD) to demonstrate its value for diagnosis prenatal management. Methods— The FMCG analysed compared postnatal ECG four arrhythmia [supraventricular tachycardia (two cases), complex tachy-/bradycardia (one case), ventricular extrasystoles case)] case right hypoplasia diagnosed by...
Abstract Wound healing requires a proper functioning of keratinocytes that migrate, proliferate and lead to competent wound closure. Impaired might be due disturbed keratinocyte function caused by the environment. Basically, chronic fluid (CWF) differs from acute (AWF). The aim this study was analyse effects AWF CWF on function. We therefore investigated migration proliferation under influence using MTT [3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide] test scratch assay....
To assess the clinical performance of three-dimensional, free-breathing, Magnetization Transfer Contrast Bright-and-black blOOd phase-SensiTive (MTC-BOOST) sequence in adult congenital heart disease (ACHD).In this prospective study, participants with ACHD undergoing cardiac MRI between July 2020 and March 2021 were scanned T2-prepared balanced steady-state free precession proposed MTC-BOOST sequence. Four cardiologists scored their diagnostic confidence on a four-point Likert scale for...
To analyse the physiologic development of fetal cardiac time intervals throughout gestation using magnetocardiography (FMCG).FMCG data 163 uncomplicated pregnancies (19th and 42nd gestational week) were analysed. Mean value, standard deviation, minimum maximum duration P-wave, QRS-complex, PR QT-interval plotted against age.QRS-complex, P wave showed a significant lengthening between 20th week. The mean QRS complex raised from 36+/-4.7 ms (week 21-24) up to 48+/-5.2 (> or =37th week),...
Abstract Purpose Simultaneous PET‐MRI improves inflammatory cardiac disease diagnosis. However, challenges persist in respiratory motion and mis‐registration between free‐breathing 3D PET 2D breath‐held MR images. We propose a non‐rigid motion‐compensated T 2 ‐mapping sequence enabling whole‐heart myocardial tissue characterization hybrid 3T PET‐MR system provides fields to correct also simultaneously acquired data. Methods Free‐breathing was implemented on system. Three datasets were with...
Abstract Purpose A 2D image navigator (iNAV) based 3D whole-heart sequence has been used to perform MRI and PET non-rigid respiratory motion correction for hybrid PET/MRI. However, only the data acquired during acquisition of is corrected motion. This study introduces evaluates an MRI-based method complete data. Methods Twelve oncology patients scheduled additional cardiac 18 F-Fluorodeoxyglucose ( F-FDG) PET/MRI 15 with coronary artery disease (CAD) F-Choline F-FCH) were included. iNAV...
Sprouty 2 (Spry2), an inhibitor of MAP kinase signaling was previously shown by our group to be induced during mechanical loading mesenchymal stem cells (MSCs). Here, we studied the implication Spry2 activation and chemically MSC differentiation. Spry expression showed immediate early response chemical induction osteogenic differentiation followed same pattern as associated gene FosB necessary for FosB, knock down also abrogated upregulation expression. was, with genes Runx-2 ALP. Neither...
Simultaneously acquired 18F-FDG PET-MR imaging and quantitative 2D T1 T2 mapping have been suggested for improved diagnostic accuracy of cardiac sarcoidosis, however misregistration between modalities sequential MR scans makes clinical interpretation challenging. Here we evaluate the feasibility recently proposed 3D joint T1/T2 sequence at a 3T system. This approach enables non-rigid motion-correction both PET data to same respiratory position, resulting in aligned volumes interpretation. In...
Respiratory motion-corrected coronary MR angiography (CMRA) has shown promise for assessing disease. By incorporating coronal 2D image navigators (iNAVs), respiratory motion can be corrected in a beat-to-beat basis using translational correction the foot-head (FH) and right-left (RL) directions bin-to-bin non-rigid addressing remaining FH, RL anterior-posterior (AP) motion. However, with this approach AP is not for. In work we investigate effect of propose virtual 3D iNAV that exploits...
Im Rahmen zweier klinischer Phase-II- bzw. -III-Studien wurden Patien-ten mit einem histologisch gesicherten metastasierendem Nierenkarzinom entweder γ-Interferon in zwei unterschiedlichen Dosierungen (100 μg/m2 3 × pro Woche über 4 h i.v. jede 2. Woche, oder 500 μg/m2, 5 24 Woche) α-2-Interferon allein (18 106 E i.m.) Kombination Vinblastin (0,1 mg/kg Körpergewicht 3. behandelt. Ziel dieser Studie war es, die Ansprechrate, Ansprechdauer, Überlebensrate, Toxizität sowie Verträglichkeit...
Die Hysterektomie stellt eine sehr häufig durchgeführte Operation dar. Trotz bewiesener Nachteile der abdominalen im Vergleich zur vaginalen wird die abdominale oft indiziert, obwohl laparoskopisch assistierte als zusätzliche Alternative Verfügung steht. Fragestellung: Wie hoch sind Komplikationsraten bei assistierten und haben sie sich den reinen angeglichen? Material Methodik: Zwischen Juli 1994 Juni 2003 wurden Krankenakten aller Patientinnen, einer oder ohne gleichzeitige...
Während der letzten zehn Jahre erfolgte eine Renaissance Schautaschen Operation in Kombination mit laparoskopischen Verfahren. Um potentielle Vorteile dieses Verfahrens zu definieren, verglichen wir vorliegenden retrospektiven Querschnittsstudie peri- und postoperative Daten von Patientinnen Zervixkarzinomen, die entweder durch vaginale radikale Hysterektomie nach Schauta kombiniert laparoskopischer paraaortaler pelviner Lymphonodektomie (n = 32) oder abdominale Wertheim-Meigs behandelt...
Simultaneously acquired 18 F-FDG PET-MR imaging and quantitative 2D T 2 -mapping have been suggested for improved diagnostic accuracy of cardiac sarcoidosis, however misregistration between modalities makes clinical interpretation challenging. Here we used a recently proposed free-breathing motion-corrected 3D whole-heart sequence simultaneously with PET at 3T system. This approach enables the non-rigid motion-correction both T2-mapping data to same respiratory position, resulting in aligned...
Motivation: T2 mapping provides quantitative myocardial tissue characterization. However, current approaches acquire several 2D contrast images which are then fitted to a model estimate the values, leading limited coverage, and long acquisition reconstruction times. Goal(s): Here we propose speed up 3D whole-heart using model-based deep learning unrolling network (MEDAL) that leverages power of machine physical knowledge. Approach: MEDAL reconstructs maps directly without reconstructing any...
A recently developed sequence, the Magnetisation Transfer Contrast Bright Blood phase SensiTive (MTC-BOOST), enables free-breathing simultaneous acquisition of a bright-blood and black-blood 3D whole-heart dataset. We sought to compare time, image quality diagnostic performance proposed MTC-BOOST against native clinical T2-prep bSSFP contrast-enhanced (CE) sequence in cohort patients with Congenital Heart Disease. Our study showed that offers good delineation intracardiac vascular anatomy is...
Dictionary generation and pattern matching are two important bottlenecks in cardiac MRF. Dictionaries must be recalculated for each new scan as they depend on the subject’s heart rate variability both dictionaries length of grow exponentially with number parameters being considered. We propose a conditional invertible neural network capable dictionary parameter estimation T 1 , 2 1ρ The achieves excellent results EPG-generated data (inner product >0.999,...
Simultaneous 18 F-FDG PET-MRI has shown promise for improved diagnostic accuracy of inflammatory cardiac diseases. However, respiratory motion and mis-registration between free-breathing 3D PET 2D breath-held MR images remain challenges that have hindered its clinical adoption. We recently proposed a non-rigid motion-compensated whole-heart T 2 -mapping enables detection myocardial inflammation provides fields to correct simultaneously acquired data in 3T PET-MR system. Here, we perform...