A5001340152- Reproductive Biology and Fertility
- Ovarian function and disorders
- Birth, Development, and Health
- Adipose Tissue and Metabolism
- Effects and risks of endocrine disrupting chemicals
- Sperm and Testicular Function
- Phytoestrogen effects and research
- Genetic and phenotypic traits in livestock
- Reproductive Physiology in Livestock
- Nutrition, Genetics, and Disease
University of Antwerp
2017-2024
Abstract Maternal obesity can cause reduced oocyte quality and subfertility. Mitochondrial dysfunction plays a central role here, most often inbred mouse models are used to study these pathways. We hypothesized that the genetic background influence impact of high fat diet (HFD)-induced on quality. compared C57BL/6 (B6) outbred Swiss strains after feeding HFD for 13w. HFD-mice had increased body weight gain, hypercholesterolemia, lipid droplet (LD) accumulation in both strains. LD...
Obese individuals often suffer from metabolic health disorders and reduced oocyte quality. Preconception diet interventions in obese outbred mice restore quality mitochondrial ultrastructure. Also, studies inbred have shown that maternal obesity induces alterations reduces offspring (F1). Until now, the effect of high-fat on F1 potential beneficial effects preconception dietary not been studied together mice. Therefore, we fed female a high-fat/high-sugar (HF/HS) for 7 weeks switched them to...
A negative energy balance in metabolically compromised high producing dairy cows has been shown to influence oocyte and embryo quality.However, the possible involved pathways needed more attention better understand specific deleterious effects.Oocyte maturation is first process be scrutinized.Because many metabolic factors might directly impact quality, systematic vitro approaches were used investigate effects of under elevated NEFA concentrations.Blastocysts originating from NEFA-exposed...
Maternal metabolic disorders are linked to reduced health and oocyte quality. Obese women advised lose weight before conception increase pregnancy chances. However, as human studies show no univocal guidelines, more research is necessary provide fundamental insights in the consequences of dietary loss on Therefore, we investigated impact diet normalization or calorie restricted for two, four six weeks, preconception care intervention (PCCI), obese mice quality.Outbred female were fed a...
Can diet normalization or a calorie-restricted for 2 4 weeks be used as preconception care intervention (PCCI) in Western-type diet-induced obese Swiss mice to restore metabolic health and oocyte quality?Metabolic developmental competence was already significantly improved the group after weeks, while that underwent showed quality weeks.Maternal obesity is linked with reduced quality; therefore, infertile women are advised lose weight before conception increase pregnancy chances. However,...
Metabolic disorders due to obesity and unhealthy lifestyle directly alter the oocyte's microenvironment impact oocyte quality. Oxidative stress mitochondrial dysfunction play key roles in pathogenesis. Acute effects on fully grown oocytes are evident, but early follicular stages also sensitive metabolic leading a long-term cells oocytes. Improving preconception health is therefore of capital importance research animal models has demonstrated that quality not recovered. In vitro fertilisation...
Elevated non-esterified fatty acid (NEFA), predominantly palmitic (PA), concentrations in blood and follicular fluid are a common feature maternal metabolic disorders such as obesity. This has direct negative impact on oocyte developmental competence the resulting blastocyst quality. We use NEFA-exposure during bovine vitro maturation (IVM) model to mimic under stress conditions. However, of supportive embryo culture conditions these metabolically compromised zygotes not known yet....
Trials to improve oocyte developmental competence under metabolic stress by using antioxidants may start before or after maturation. In the present conceptual study, we aimed identify most efficient timing of antioxidant application in relation a insult bovine invitro embryo production model. Pathophysiological concentrations palmitic acid (PA) were used induce during maturation development. Trolox (TR; antioxidant) treatment prior to, PA was tested evaluate protective, neutralising and...
Maternal metabolic disorders such as obesity and syndrome are linked to decreased oocyte embryo quality thus reproductive failure. Overweight obese patients advised lose weight before conception increase the chance of a healthy pregnancy. Human studies show conflicting results often underpowered, leading lack scientifically substantiated advice. Furthermore, effects significant loss, due caloric restriction, on not known. Therefore, we aimed feed normal control or low-calorie diet...
Maternal metabolic disorders like obesity and diabetes type II are known to affect reproductive physiology, ultimately leading poor fertility. The oocyte embryo extremely vulnerable during the periconceptional period stressors, disappointing fertility results. Most mouse model research regarding Western diets has been performed on inbred C57BL/6 strain. However, strains often linked with decreased Relying only might also limit translation human (outbred) physiology. To further explore this,...
Abstract Study question Can diet normalization or caloric restriction (CR) for two weeks be used as a preconception care intervention in obese Swiss mice to restore oocyte development and quality Summary answer Diet CR short-term interventions only partially restored but did improve overall developmental competence. What is known already Maternal metabolic disorders like obesity syndrome may result decreased embryo quality, thus reproductive failure. Overweight patients are advised lose...