A5048644493- Gastrointestinal motility and disorders
- Pharmacological Effects of Natural Compounds
- Trypanosoma species research and implications
- Research on Leishmaniasis Studies
- Brain Tumor Detection and Classification
- Image Retrieval and Classification Techniques
- Helicobacter pylori-related gastroenterology studies
- Cancer, Hypoxia, and Metabolism
- Biochemical effects in animals
- Diet and metabolism studies
- Pregnancy-related medical research
- Nanoplatforms for cancer theranostics
- Metabolism, Diabetes, and Cancer
- Food Quality and Safety Studies
- Lysosomal Storage Disorders Research
- Ion Channels and Receptors
- Gestational Diabetes Research and Management
- Photodynamic Therapy Research Studies
- Polysaccharides and Plant Cell Walls
- Diet, Metabolism, and Disease
- Maternal and Neonatal Healthcare
- Regulation of Appetite and Obesity
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Toxin Mechanisms and Immunotoxins
- Traditional Chinese Medicine Studies
Universidade Estadual de Maringá
2012-2024
University of Antwerp
2018-2019
Abstract Objective To assess the susceptibility of T rypanosoma cruzi strains from A mazon to benznidazole. Methods We studied 23 T. obtained humans in acute phase C hagas disease, triatomines and marsupials state Amazonas chronic patients P araná, B razil. The were classified as c I (6), II (4) IV (13). For each strain, 20 S wiss mice inoculated: 10 treated orally with benznidazole 100 mg/kg/day ( TBZ group) for consecutive days comprised untreated control group NT ). Fresh blood...
The aim of our study was to the pathological mechanisms induced by rheumatoid arthritis (RA) on Enteric Nervous System (ENS).We evaluated effect chronic and its treatment with 50 mg/kg quercetin alone (AQ) combined 17.5 ibuprofen (AIQ) for 60 days neurons, glial cells intestinal wall. Other groups were used: control (C), arthritic (A) treated (AI). After days, jejunum removed processed immunohistochemical techniques. Immunostainings performed HuC/D S100 (myenteric submucosal plexuses), GFAP...
The intestinal wall has a complex topographical architecture. multi-layered network of the enteric nervous system and its intercellular interactions are difficult to map using traditional section-based or whole-mount histology. With advent optical clearing techniques, it become feasible visualize intact tissue organs in 3D. However, as yet, gap still needs be filled that no in-depth analysis been performed yet on potential different techniques for small intestine.The goal this study was...
Enteric glial cells (EGCs) exert a critical role in the structural integrity, defense, and metabolic function of enteric neurons. Diabetes mellitus is chronic disease characterized by disorders autonomic neuropathy. Quercetin supplementation, which potent antioxidant, has been used order to reduce effects diabetes-induced oxidative stress. The purpose this research was investigate quercetin supplementation drinking water at daily dose 40 mg on neurons jejunum diabetic rats.Twenty 90-day-old...
The biological behaviour of 23 Trypanosoma cruzi isolates in Swiss mice was compared. Nineteen were obtained from patients the acute phase Chagas disease (13), sylvatic reservoir hosts (Didelphis marsupialis) (3), and triatomine bugs (Rhodnius robustus) (3) four regions State Amazonas (AM). Four chronic chagasic Paraná (PR): three autochthones, one allochthone Minas Gerais. Only isolate unable to infect mice. AM PR showed largest number significant differences each other. former had lower...
We evaluated the effects of supplementation with oral l-glutamine in Walker-256 tumor–bearing rats. A total 32 male Wistar rats aged 54 days were randomly divided into four groups: without tumor, that is, control (C group); supplemented (CG tumor (WT and WT (WTG group). l-Glutamine was incorporated standard food at a proportion 2 g/100 g (2%). After 10 experimental period, jejunum duodenum removed processed. Protein expression levels key enzymes gluconeogenesis, phosphoenolpyruvate...
Interstitial cells of Cajal (ICC) are required for normal motility in the gastrointestinal tract. Depletion ICC has been associated with diabetic gastroenteropathy.To determine effect quercertin supplementation on anoctamin-1 (Ano1) immunoreactive myenteric region (ICC-MY) and deep muscular plexus (ICC-DMP) jejunum rats.Thirty-two 90-day-old male Wistar rats were distributed into following groups: normoglycemic (C), supplemented quercetin (CQ; 40 mg daily), (D), (DQ; daily). Diabetes was...
Chagas' disease is a parasitic with unsatisfactory treatment, mainly in chronic stage.This study aimed to evaluate the trypanocidal activity and action mechanisms of α/β-amyrin its semisynthetic derivatives, together four isolated natural triterpenes, tested against trypomastigote amastigote forms.The structure-activity relationship was suggested cytotoxicity measured.In general, greater polar compounds may have improved selectivity protozoan.Action were only performed for amastigotes...
The spatial distribution of enteroparasitosis in an indigenous village from Paraná was evaluated to identify areas risk for these infections. A cross-sectional study (from November 2010 June 2011) performed using Three Faecal Test(®) and Kato & Katz method a questionnaire on housing hygiene conditions administered. Local geostatistical analyses were determine the intestinal parasitic overall prevalence enteroparasites 67.2 % (457/680), most prevalent taxa Ascaris lumbricoides (48.8 %)...
Serotonin (5-HT) is present in the epithelial enterochromaffin cells (EC), mast of lamina propria and enteric neurons. The 5-HT involved regulating motility, secretion, gut sensation, immune system inflammation.Evaluate effects diabetes quercetin supplementation on serotoninergic its cell loss by apoptosis jejunal mucosa streptozotocin-induced diabetic rats (STZ-rats).Twenty-four male Wistar were divided into four groups: normoglycemic (C), supplemented with 40 mg/day (Q), (D) (DQ). After...
This study aimed to investigate the antioxidant and anti-inflammatory properties of quercetin on cellular components Enteric Nervous System in ileum rats with arthritis. Rats were distributed into five groups: control (C), arthritic (AIA), treated ibuprofen (AI), (AQ) both (AIQ). The was processed for immunohistochemical techniques HuC/D, calcitonin gene-related peptide, vasoactive intestinal polypeptide. Measurements histological sections, chemiluminescence assays, total capacity also...
The intestinal wall has a complex 3D architecture, consisting of epithelial, immune, vascular, smooth muscle and neuronal components. Traditional 2D techniques are by definition destructive therefore fail to provide faithful representation this tissue. With an eye on visualizing intact tissue in toto, several optical clearing methods aimed at reducing scattering absorption photons, have been re‐examined or newly developed. Four hydrophilic solvent‐based protocols (SeeDB2G/S, modified CUBIC,...
ABSTRACT BACKGROUND: Few studies regarding arthritic diseases have been performed to verify the presence of neurodegeneration. Given increased oxidative stress and extra-articular effects rheumatoid arthritis, gastrointestinal should be further investigated aiming a better understanding systemic disease on enteric nervous system. OBJECTIVE: To determine whether arthritis affects nitrergic density somatic area nNOS- immunoreactive (IR) myenteric neurons, as well morphometric areas CGRP VIP-IR...
Studies recently accomplished on the Enteric Nervous System have shown that chronic degenerative diseases affect Glial Cells (EGC) and, thus, development of recognition methods able to identify whether or not EGC are affected by these type may be helpful in its diagnoses. In this work, we propose use pattern and machine learning techniques evaluate if a given animal image was obtained from healthy individual one disease. proposed approach, performed classification task with handcrafted...