A5049026476- Herpesvirus Infections and Treatments
- Poxvirus research and outbreaks
- Malaria Research and Control
- Bacillus and Francisella bacterial research
- Amoebic Infections and Treatments
- Parasitic Infections and Diagnostics
- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Drug-Induced Hepatotoxicity and Protection
- HIV/AIDS Research and Interventions
- Fire effects on ecosystems
- Animal Vocal Communication and Behavior
- Parasites and Host Interactions
- Reproductive tract infections research
- bioluminescence and chemiluminescence research
- Animal Behavior and Reproduction
- Syphilis Diagnosis and Treatment
- Viral Infections and Outbreaks Research
- Mesenchymal stem cell research
- Research on Leishmaniasis Studies
- Cell Image Analysis Techniques
- RNA Interference and Gene Delivery
- Vector-borne infectious diseases
- Diagnosis and treatment of tuberculosis
- Polyomavirus and related diseases
Instituut voor Tropische Geneeskunde
2014-2023
University of Antwerp
2008-2011
The magnitude of the 2022 multi-country monkeypox virus (MPXV) outbreak has surpassed any preceding outbreak. It is unclear whether asymptomatic or otherwise undiagnosed infections are fuelling this epidemic. In study, we aimed to assess occurred among men attending a Belgian sexual health clinic in May 2022. We retrospectively screened 224 samples collected for gonorrhea and chlamydia testing using an MPXV PCR assay identified MPXV-DNA-positive from four men. At time sampling, one man had...
Abstract Background Cell transplantation is likely to become an important therapeutic tool for the treatment of various traumatic and ischemic injuries central nervous system (CNS). However, in many pre-clinical cell therapy studies, reporter gene-assisted imaging cellular implants CNS potential gene and/or cell-based immunogenicity, still remain challenging research topics. Results In this study, we performed implantation experiments immunocompetent mice using autologous (syngeneic)...
The risk of infection after exposure to clade IIb mpox virus (MPXV) is unknown, and potential presymptomatic shedding MPXV remains be demonstrated. High-risk contacts patients were followed-up in a prospective longitudinal cohort study. Individuals reporting sexual contact, >15 min skin-to-skin or living the same household with an patient recruited health clinic Antwerp, Belgium. Participants kept symptom diary, performed daily self-sampling (anorectal, genital, saliva), presented for weekly...
Mpox (formerly monkeypox) is a viral disease caused by the mpox virus (MPXV), endemic in Central and West Africa currently causing global outbreak of international concern. Much remains unknown about sample types most suited for laboratory diagnosis. While it established that high loads can be found active skin lesions (currently recommended confirmation specimen type), WHO testing guidelines encourage use oropharyngeal swabs as an additional type diagnosis suggest investigating value other...
The presentation of mpox clade IIb during the 2022 outbreak overlaps with a range other diseases. Understanding factors associated is important for clinical decision making.We described characteristics patients who sought care at Belgian sexual health clinic. Furthermore we compared their to those suspicion but tested negative on polymerase chain reaction.Between May 23 and September 20, 2022, 155 were diagnosed mpox, 51 suspected symptoms negative. All self-identified as men 148/155 (95.5%)...
Background Amebiasis is a protozoal infection caused by Entamoeba histolytica, while the morphologically indistinguishable E. dispar considered as non-pathogenic. Polymerase chain reaction (PCR) assays are necessary to differentiate both species. The most common clinical presentations of histolytica disease amebic colitis and liver abscess, but asymptomatic also possible. We assessed frequency pattern symptoms microscopic features in travelers/migrants associated with intestinal compared...
Abstract Background Failure of artemisinin-based combination therapy is increasingly reported in patients with Plasmodium falciparum malaria sub-Saharan Africa. We aimed to describe the clinical and genomic characteristics recent cases P. failing artemether-lumefantrine Belgium. Methods Travel-related confirmed at national reference laboratory Institute Tropical Medicine, Antwerp, Belgium, were reviewed. All for which attending clinicians persistence (beyond Day 3 post-treatment initiation,...
A bstract Epidemiological data suggest that clade IIb monkeypox virus (MPXV) is readily transmitted during sexual contact, even before symptom onset. However, presymptomatic shedding of MPXV remains to be demonstrated. Here, we prospectively followed up 25 individuals after high-risk exposure MPXV. Daily anorectal, genital, and saliva samples weekly blood oropharyngeal were collected along with clinical information. During follow-up, 12/18 (66.0%) 1/7 (14.0%) non-sexual contacts showed...
The Belgian Reference Laboratory for Plasmodium offers a free-of-charge reference testing of malaria-positive or doubtful samples to clinical laboratories.The final malaria diagnosis from the (microscopy, rapid diagnostic tests (RDTs) and species-specific PCR) were compared with peripheral laboratories. reports analysed all submitted between 2013 2017. Criteria assessed included malaria, species identification including mixed infections, in case falciparum, parasite density presence sexual...
Background Manually performed nontreponemal assays, such as rapid plasma reagin (RPR), are labor intensive and time consuming. Recently, commercial automated RPR assays gained attention. The aim of this study was to compare the qualitative quantitative performance AIX1000 (RPR-A; Gold Standard Diagnostics) a manual test (RPR-M; Becton Dickinson Macrovue) within high-prevalence setting. Methods A retrospective panel 223 samples selected for comparison between RPR-A RPR-M, including 24 from...