A5032599774- Cystic Fibrosis Research Advances
- Asthma and respiratory diseases
- Neonatal Respiratory Health Research
- Immunodeficiency and Autoimmune Disorders
- Bacterial biofilms and quorum sensing
- Inhalation and Respiratory Drug Delivery
- Tracheal and airway disorders
- Allergic Rhinitis and Sensitization
- Child Nutrition and Feeding Issues
- Pediatric health and respiratory diseases
- Infections and bacterial resistance
- Antibiotic Resistance in Bacteria
- Respiratory and Cough-Related Research
- Pneumocystis jirovecii pneumonia detection and treatment
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Childhood Cancer Survivors' Quality of Life
- Blood disorders and treatments
- Respiratory viral infections research
- Congenital Diaphragmatic Hernia Studies
- Tuberculosis Research and Epidemiology
- Cerebrospinal fluid and hydrocephalus
- Antifungal resistance and susceptibility
- Mycobacterium research and diagnosis
- Antibiotic Use and Resistance
- Pancreatitis Pathology and Treatment
Ghent University Hospital
2012-2022
University of Wisconsin–Madison
2017
Bambino Gesù Children's Hospital
2015
Ghent University
1988-2013
Utrecht University
2011
Universitair Ziekenhuis Brussel
2004-2011
National Hospital
2010
Children's Hospital of Chongqing Medical University
2010
Ministry of Health
2010
Karolinska University Hospital
2010
Interleukin-12 receptor β1 (IL-12Rβ1) deficiency is the most common form of Mendelian susceptibility to mycobacterial disease (MSMD). We undertook an international survey 141 patients from 102 kindreds in 30 countries. Among probands, first infection occurred at a mean age 2.4 years. In 78 patients, this was caused by Bacille Calmette-Guérin (BCG; n = 65), environmental mycobacteria (EM; also known as atypical or nontuberculous mycobacteria) (n 9) Mycobacterium tuberculosis 4). Twenty-two...
Cystic fibrosis (CF) is characterized by the presence of a viscoelastic mucus layer in upper airways and bronchi. The underlying problem mutation gene encoding cystic transmembrane conductance regulator protein. Clinical studies transfer for CF are ongoing. For delivery to patients be effective, covering target cells must overcome. We therefore examined extent which sputum presents physical barrier transport nanospheres size comparable that lipoplexes other transfection systems currently...
Aim: The aim of this study was to evaluate the effect surface functionalization model nanoparticles on their mobility in bacterial biofilms and cystic fibrosis sputum. Materials & methods: With single-particle tracking microscopy, 0.1- 0.2-µm fluorescent polyethylene glycol (PEG) modified, carboxylate- N,N-dimethylethylenediamine-modified polystyrene nanospheres were evaluated fresh sputum, as well Burkholderia multivorans Pseudomonas aeruginosa biofilms. Results: PEGylation increased...
Exercise-induced asthma (EIA) is a possible cause of poor physical performance in children. No data are available on the value respiratory symptoms to discriminate children with bad fitness from EIA. We evaluated school-age during and after exercise relation The population 149 primary schools (849 classes 15,241 children) was enrolled study. EIB assessed using 6-min free-running-test (6MFRT) At end or at premature arrest 6MFRT, signs reported by clinical observed supervising physicians were...
Boys run a higher risk for atopy than girls but this gender difference is less pronounced in adulthood. The underlying mechanisms and the exact timing of decrease male/female ratio remain unclear. aim study was to evaluate effect age on sensitization schoolchildren. A cross‐sectional performed an unbiased community population 2021 Belgian schoolchildren, aged 3.4–14.8 yr. overall mites, mixed grass pollens tree increased significantly with increasing age. Male sex strongly associated (OR adj...
Abstract Background Pseudomonas aeruginosa is the major pathogen involved in decline of lung function cystic fibrosis (CF) patients. Early aggressive antibiotic therapy has been shown to be effective preventing chronic colonization. Therefore, early detection important and sensitive methods are warranted. In this study, we used a dilution series P. positive sputa, diluted pool negative all from CF patients - mimick as closely possible sputa sent routine laboratories compare sensitivity three...
Objective To prospectively investigate the role of acceptance in well-being adolescents and young adults with cystic fibrosis (CF). Method A total 40 CF (ages 14–22 years) completed questionnaires assessing acceptance, anxiety depressive symptoms, physical functioning, emotional social functioning. After 6 months, 28 them on functioning a second time. Results More (Time 1) was related to less symptoms 1 2), better role, emotional, 1). Conclusions indicate that accepting limitations imposed...
The source of acquisition Pseudomonas aeruginosa in cystic fibrosis (CF) patients remains unknown. Patient-to-patient transmission has been well documented but the role environment as a initial infection is yet unclear. In present study, origin first P. isolate CF was investigated by comparing genotype(s) from newly infected with genotypes isolates home and other same centre. A total 50 were studied. could be cultured 5.9% environmental samples, corresponding to 18 patients. For nine these,...
In children with persistent respiratory symptoms despite regular anti-asthma inhalation treatment, diagnostic investigations to exclude underlying disease are warranted. 124 were prospectively enrolled, and 24-h oesophageal pH measurement fibreoptic bronchoscopy bronchoalveolar lavage (BAL) performed. BAL fluid (BALF) was processed for neutrophil counting bacterial culture. Inflammation of the mucosa assessed. A structural abnormality central airways found in 47% subjects (40% females). 19%...
Background Antibiotics are overprescribed for non-severe acute infections in children primary care. Aim To explore two different interventions that may reduce inappropriate antibiotic prescribing infections. Design and setting A cluster randomised, factorial controlled trial care, Flanders, Belgium. Method Family physicians (FPs) enrolled with into this study. The participants were allocated to one of four intervention groups according whether the FPs performed: (1) a point-of-care...
During a study examining transmission of Pseudomonas aeruginosa among 76 cystic fibrosis patients in rehabilitation center, where stay close contact during prolonged periods, several clusters carrying genotypically identical P. aeruginosa, as well two 4 and 10 patients, respectively, colonized with Achromobacter xylosoxidans strains, were discovered.
The clinical and molecular findings in an infant with mild manifestations of cystic fibrosis, who is homozygous for the G542X mutation, her heterozygous nephew, severely affected, are described.
Results of studies the influence body mass index (BMI) on allergic status are controversial. As a part Aalst Allergy Study, we assessed prevalence different BMI categories (underweight, normal weight, overweight, and obesity) possible association between atopy in 1576 unselected Belgian schoolchildren, aged from 3.4 to 14.8 yr. was used determine weight status. Skin prick testing with most common aeroallergens performed. A parental questionnaire documented data respiratory disorders,...
Modern guidelines for the management of asthma state that asthmatic patients should be strongly advised not to smoke. However, it remains unclear what extend young people with actually behave like this. This study compares prevalence daily smoking between 15-year adolescents diagnosed and without asthma, evaluates extent risk factors play a comparable role in behaviour these two groups.The is part 2001-2002 international HBSC study. Besides questions about health behaviour, individual social...