A5047891087- Cystic Fibrosis Research Advances
- Neonatal Respiratory Health Research
- Pediatric health and respiratory diseases
- Tracheal and airway disorders
- Asthma and respiratory diseases
- Respiratory viral infections research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Telemedicine and Telehealth Implementation
- Pneumonia and Respiratory Infections
- Delphi Technique in Research
- Neurobiology and Insect Physiology Research
- Bacterial Infections and Vaccines
- Animal Behavior and Reproduction
- Amphibian and Reptile Biology
- Olfactory and Sensory Function Studies
- Influenza Virus Research Studies
- Birth, Development, and Health
- Cardiovascular Syncope and Autonomic Disorders
- Antimicrobial Peptides and Activities
- Bacterial biofilms and quorum sensing
- Interprofessional Education and Collaboration
- Stroke Rehabilitation and Recovery
- HIV/AIDS Impact and Responses
- Urological Disorders and Treatments
- Congenital Diaphragmatic Hernia Studies
University of Virginia
2024-2025
University of Southampton
2012-2020
National Institute for Health Research
2020
NIHR Southampton Biomedical Research Centre
2013-2019
University Hospital Southampton NHS Foundation Trust
2013-2018
NIHR Southampton Respiratory Biomedical Research Unit
2013-2018
Wellcome Trust
2016
Southampton General Hospital
2016
Southampton Children's Hospital
2013
Royal Children's Hospital
2011
The diagnosis of primary ciliary dyskinesia is often confirmed with standard, albeit complex and expensive, tests. In many cases, however, the remains difficult despite array sophisticated diagnostic There no "gold standard" reference test. Hence, a Task Force supported by European Respiratory Society has developed this guideline to provide evidence-based recommendations on testing, especially in light new developments such tests, need for robust diagnoses patients who might enter randomised...
Diagnosis of primary ciliary dyskinesia (PCD) lacks a “gold standard” test and is therefore based on combinations tests including nasal nitric oxide (nNO), high-speed video microscopy analysis (HSVMA), genotyping transmission electron (TEM). There are few published data the accuracy this approach. Using prospectively collected from 654 consecutive patients referred for PCD diagnostics we calculated sensitivity specificity individual combination testing strategies. Not all underwent tests....
Abstract Background In 1995 the Tucson Children's Respiratory Study (TCRS) identified clinically distinct phenotypes amongst early wheezers; Avon Longitudinal of Parents And Children (ALSPAC) has recently re‐examined these. Objectives To validate statistically derived ALSPAC in Southampton Women's Survey (SWS) using infant and 6‐year lung function, allergic sensitization at 1, 3, 6 years, comparing these with TCRS phenotypes. Methods Complete follow‐up data were available for 926 children,...
Clinical management of primary ciliary dyskinesia (PCD) respiratory disease is currently based on improving mucociliary clearance and controlling infections, through the administration antibiotics. Treatment practices in PCD are largely extrapolated from more common chronic disorders, particularly cystic fibrosis, but no randomized controlled trials (RCT) have ever evaluated efficacy safety any pharmacotherapeutics used treatment PCD. Maintenance therapy, with macrolide antibiotic...
Background: Telehealth can provide innovative models of care for people living in congregate communities (CCC), but lack consistent workflow is a barrier administrators and staff. We propose framework CCC to implement workflows age-inclusive telehealth. Methods: As part an infection control initiative with focus on telehealth optimization, Virginia Infection Mitigation, Prevention Control Through Technology developed relationships staff across the Commonwealth Virginia. Partners this...
Non-typeable <i>Haemophilus influenzae</i> (NTHi) is the most common pathogen in primary ciliary dyskinesia (PCD) patients. We hypothesised that abnormal motility and low airway nitric oxide (NO) levels on epithelial cells from PCD patients might be permissive for NTHi colonisation biofilm development. used a cell co-culture model to investigate infection. Primary non-PCD were differentiated ciliation using an air–liquid interface culture then co-cultured with NTHi. adherence was greater...
PYRRO-C3D is a cephalosporin-3-diazeniumdiolate nitric oxide (NO) donor prodrug designed to selectively deliver NO bacterial infection sites. The objective of this study was assess the activity against nontypeable Haemophilus influenzae (NTHi) biofilms and examine role in reducing biofilm-associated antibiotic tolerance. on vitro NTHi assessed through CFU enumeration confocal microscopy. release measurements were performed using an ISO-NO probe. grown primary ciliated respiratory epithelia...
Chronic cardiorespiratory disease is associated with low birthweight suggesting the importance of developmental environment. Prenatal factors affecting fetal growth are believed important, but underlying mechanisms unknown. The influence programming on bronchial hyperreactivity investigated in an animal model and evidence for comparable associations sought humans. Pregnant Wistar rats were fed either control or protein-restricted diets throughout pregnancy. Bronchoconstrictor responses...
It has long been recognized that learning can be impaired when animals are infected or immunodepressed. Several things could account for this, including deficits in exploratory activity attention due to stress, metabolic burden parasitic manipulation. With the exception of manipulation, such effects may reflect an adaptive trade-off investment between and either maintaining steady-state immune responsiveness mounting a response infection. One prediction hypothesis is increased effort, which...