A5047418643- Bariatric Surgery and Outcomes
- Metabolism, Diabetes, and Cancer
- Diabetes Treatment and Management
- Diet and metabolism studies
- Metabolism and Genetic Disorders
- Dietary Effects on Health
- Mitochondrial Function and Pathology
- Pancreatic and Hepatic Oncology Research
- Ocular Surface and Contact Lens
- Opioid Use Disorder Treatment
- Schizophrenia research and treatment
- Bipolar Disorder and Treatment
- Healthcare cost, quality, practices
- Blood Pressure and Hypertension Studies
- Vitamin C and Antioxidants Research
- Circadian rhythm and melatonin
- Climate Change and Health Impacts
- Pharmaceutical Practices and Patient Outcomes
- Emergency and Acute Care Studies
- Management of metastatic bone disease
- Treatment of Major Depression
- Pharmaceutical industry and healthcare
- Health and Medical Research Impacts
- Glaucoma and retinal disorders
- Metabolomics and Mass Spectrometry Studies
Rutgers, The State University of New Jersey
2012-2025
Rutgers New Jersey Medical School
2007-2025
Johnson University
2012-2024
Thieme Medical Publishers (Germany)
2024
Sylvester Comprehensive Cancer Center
2024
University of Miami
2023-2024
Smt. N.H.L. Municipal Medical College
2023
Rutgers Cancer Institute of New Jersey
2022-2023
Alkermes (United States)
2018-2021
Takeda (United States)
2021
Insulin resistance in skeletal muscle is a key phenotype associated with type 2 diabetes (T2D) for which the molecular mediators remain unclear. We therefore conducted an expression analysis of human biopsies from patients T2D; normoglycemic but insulin-resistant subjects parental family history (FH(+)) and history-negative control individuals (FH(–)). Actin cytoskeleton genes regulated by serum response factor (SRF) its coactivator megakaryoblastic leukemia 1 (MKL1) had increased T2D FH(+)...
Nonalcoholic fatty liver disease (NAFLD), the most common disease, has become a silent worldwide pandemic. The incidence of NAFLD correlates with rise in obesity, type 2 diabetes, and metabolic syndrome. A hallmark featureof is excessive hepatic fat accumulation or steatosis, due to dysregulated metabolism, which can progress nonalcoholic steatohepatitis (NASH), fibrosis, cirrhosis. Currently, there are no approved pharmacotherapies treat this disease. Here, we have found that activation...
Abstract Aim Chronotype reflects a circadian rhythmicity that regulates endothelial function. While the morning chronotype (MORN) usually has low cardiovascular disease risk, no study examined insulin action on function between chronotypes. We hypothesized intermediate chronotypes (INT) would have lower vascular sensitivity than (MORN). Materials and Methods Adults with obesity were classified per Morningness‐Eveningness Questionnaire (MEQ) as either MORN (n = 27, 22 female, MEQ 63.7 ± 4.7,...
Treatment-resistant depression (TRD), defined as episodes of that do not respond to ≥ 2 lines adequate therapy, is associated with a high economic burden. Although the burden TRD reported elsewhere, its exact magnitude and current value uncertain due differences in methodology identification.
This essay describes a physician’s turmoil in being unable to help treatable but uninsured and undocumented patient the patient’s path finding solution.
ABSTRACT Objectives People with later chronotypes are at greater T2D risk, yet it is unknown if β‐cell function differs among chronotypes. Thus we, assessed in morning (MORN) and intermediate (INT) obesity. Methods Adults ( n = 41, 9M, 55 ± 1.7 y, 36.8 1.0 kg/m 2 ) were grouped as MORN or INT per the Morningness‐Eveningness Questionnaire. Glucose, insulin, C‐peptide, GIP, GLP‐1(active) collected every 30 min during a 120 75g‐OGTT. Insulin secretion rates (ISR) calculated (regularized...
This study compares blood pressure and heart rate responses with graded, incremental exercise between morning intermediate chronotype adults obesity. Herein, to were elevated in compared chronotype, although V̇o 2max abolished this observation. However, higher vs. chronotypes independent of fitness. Collectively, hemodynamic response among may be related reduced aerobic fitness, altered nitric oxide metabolism, and/or aortic waveforms.
Type 2 diabetes (T2D) patients have an increased fracture risk, which may be partly explained by compromised bone microarchitecture within the cortical compartment. Data on trabecular parameters in T2D are contradictory. By high-resolution peripheral quantitative computed tomography (HR-pQCT), is preserved, yet larger holes detected MRI and DXA-based scores abnormal. To determine if there differences microstructure, connectivity, alignment postmenopausal women with as compared controls, we...
Hepatic insulin clearance is a significant regulator of glucose homestasis. We hypothesized that the improvement in rates (ICRs) under fasting conditions and response to oral intravenous (IV) would improve similarly after Roux-en-Y gastric bypass (RYGB) adjustable banding (AGB) as function weight loss; difference ICR IV stimulation will be enhanced RYGB compared with AGB, an effect mediated by glucagon-like peptide 1 (GLP-1).In study 1, was calculated condition (F-ICR), (O-ICR), isoglycemic...
OBJECTIVE The role of the gut in diabetes remission after Roux-en-Y gastric bypass (RYGB) is incompletely understood. We assessed temporal change insulin secretory capacity RYGB, using oral and intravenous (IV) glucose, individuals with type 2 diabetes. RESEARCH DESIGN AND METHODS Longitudinal, prospective measures β-cell function were glucose intake graded infusion severe obesity studied at 0, 3 (n = 29), 12 24), 24 20) months RYGB. Data collected between 2015 2019 an academic clinical...
The present study was a 4‐week randomized trial to assess the efficacy and safety of sitagliptin, dipeptidyl‐peptidase‐4 inhibitor, in persistent or recurring type 2 diabetes after Roux‐en‐Y gastric bypass surgery (RYGB). Participants (n = 32) completed mixed meal test (MMT) self‐monitoring plasma glucose (SMPG) before 4 weeks randomization either sitagliptin 100 mg daily placebo daily. Questionnaires were administered gastrointestinal discomfort. Outcome variables glucose, active...
Glycerol kinase deficiency (GKD) is an X-linked recessive disorder due to
Continuous antipsychotic therapy is recommended as part of long-term maintenance treatment schizophrenia, and gaps in have been associated with increased risks relapse rehospitalization. Because the use long-acting injectable (LAI) antipsychotics may reduce likelihood undetected medication gaps, initiating an LAI affect resource utilization costs. The aripiprazole lauroxil (AL) was approved United States (US) 2015 for schizophrenia adults. objective this retrospective observational cohort...
Opioid use disorder (OUD) can be managed with medication assisted therapy (MAT) (methadone [MET], buprenorphine [BUP], or extended-release naltrexone [XR-NTX]) counseling alone (non-pharmacological [NPT]). The objective of this study was to evaluate healthcare resource utilization and costs associated XR-NTX compared alternative treatments for opioid dependence.Adults a diagnosis dependence who initiated treatment XR-NTX, BUP, MET, NPT between January 1, 2011 December 31, 2014 were...
Abstract Objectives Friedreich ataxia (FRDA) is a rare disorder with progressive neurodegeneration and cardiomyopathy. Luvadaxistat (also known as TAK‐831; NBI‐1065844), an inhibitor of the enzyme d ‐amino acid oxidase, has demonstrated beneficial effects in preclinical models relevant to FRDA. This phase 2, randomized, double‐blind, placebo‐controlled, parallel‐arm study evaluated efficacy safety oral luvadaxistat adults Methods Adult patients FRDA were randomized 2:1:2 placebo, 75 mg twice...
The contribution of endogenous glucagon-like peptide (GLP)-1 to β-cell function after Roux-en-Y gastric bypass surgery (RYGB) is well established in normoglycaemic individuals, but not those with postoperative hyperglycaemia. We, therefore, studied the effect GLP-1 on individuals varying degrees type 2 diabetes mellitus (T2D) control RYGB.
Fasting hyperglycemia in diabetes mellitus is caused by unregulated glucagon secretion that activates gluconeogenesis (GNG) and increases the use of pyruvate, lactate, amino acids, glycerol. Studies GNG hepatocytes, however, tend to test a limited number substrates at nonphysiologic concentrations. Therefore, we treated cultured primary hepatocytes with three identical substrate mixtures pyruvate/lactate, glutamine, glycerol serum fasting concentrations, where different U-