A5058696246- Diabetes Management and Research
- Gestational Diabetes Research and Management
- Pancreatic function and diabetes
- Diabetes and associated disorders
- Pregnancy and preeclampsia studies
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Diabetes Treatment and Management
- Bariatric Surgery and Outcomes
- Birth, Development, and Health
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diet and metabolism studies
- Pharmacology and Obesity Treatment
- Metabolism, Diabetes, and Cancer
- Diabetes Management and Education
- Cardiovascular Function and Risk Factors
- Hormonal and reproductive studies
- Retinal Diseases and Treatments
- Advanced Control Systems Optimization
- Mobile Health and mHealth Applications
- Renal cell carcinoma treatment
- Immunodeficiency and Autoimmune Disorders
- Breastfeeding Practices and Influences
- Sexual Differentiation and Disorders
- Growth Hormone and Insulin-like Growth Factors
- Spectroscopy Techniques in Biomedical and Chemical Research
University of California, Santa Barbara
2006-2018
University of Southern California
2017-2018
University of Washington
1987-2017
Sansum Diabetes Research Institute
2006-2015
Translational Research Institute
2015
Prostate Cancer Research
2015
Queensland University of Technology
2015
Sansum Medical Clinic
1987-2004
Medical Research Institute
2004
Schneider Children's Medical Center
2003
During a prospective study of pregnancies in women with systemic lupus erythematosus, we examined the relation between antibody to cardiolipin, measured by enzyme-linked immunosorbent assay, and midpregnancy fetal distress, identified abnormal results antepartum heart-rate testing or death. All nine patients this complication had abnormally high levels (mean, 212.3 +/- 55.3 units), as compared values normal nonpregnant (28.2 10.1 units). None 12 pregnant but without above 50 units 27.5 3.4...
Significance Vascular complications are the main cause of morbidity and mortality in diabetic population. Clinical trials show a persistence benefit from early application intensive therapy for glycemic control patients, phenomenon referred to as metabolic memory. The mechanisms underlying memory not fully understood. In this study, using two groups type 1 patients with without development sets genomic DNAs collected 16–17 y apart same we showed persistency DNA methylation over time at key...
OBJECTIVE: To compare the immunologic response to insulin lispro with that regular human insulin, thereby assuring its safety for use in women gestational diabetes, and verify it is effective. RESEARCH DESIGN AND METHODS: We compared metabolic effects of 42 >18 years age diagnosed diabetes by oral glucose tolerance testing at 14-32 weeks gestation. Patients were randomized receive or before consuming a test meal. Serum blood glucose, C-peptide concentrations measured. Throughout...
In order for an "artificial pancreas" to become a reality ambulatory use, practical closed-loop control strategy must be developed and validated. this paper, improved PID blood glucose is proposed critically evaluated in silico using physiologic model of Hovorka et al. [1]. The key features the are: 1) switching initiating after meal insulin bolus; 2) novel time-varying setpoint trajectory; 3) noise derivative filters reduce sensitivity sensor noise; 4) controller tuning strategy. Simulation...
Background: Development of an artificial pancreas based on automatic closed-loop algorithm that uses a subcutaneous insulin pump and continuous glucose sensor is goal for biomedical engineering research. However, closing the loop still presents many challenges, including model identification design control will keep type 1 diabetes mellitus subject in normoglycemia longest duration under maximal safety considerations. Method: An pancreatic β-cell zone predictive (zone-MPC) tuned...
Type 1 diabetes mellitus (T1DM) is characterized by the destruction of pancreatic beta cells, resulting in inability to produce sufficient insulin maintain normoglycemia. As a result, people with T1DM depend on exogenous that given either multiple daily injections or an pump control their blood glucose. A challenging task design next step therapy: fully automated delivery system consisting artificial cell shall provide both safe and effective therapy. The core such algorithm calculates dose...
An artificial pancreas (AP) that automatically regulates blood glucose would greatly improve the lives of individuals with diabetes. Such a device prevent hypo- and hyperglycemia along associated long- short-term complications as well ease some day-to-day burden frequent measurements insulin administration.We conducted pilot clinical trial evaluating an individualized, fully automated AP using commercial devices. Two trials (n = 22, n(subjects) 17) were multiparametric formulation model...
OBJECTIVE Intensive treatment (INT) of type 1 diabetes reduces the incidence cardiovascular disease (CVD) events compared with conventional (CONV), but it also results in more weight gain. Our objective was to examine whether excessive gain from INT is independently associated subsequent CVD events. RESEARCH DESIGN AND METHODS Quartiles (Q) 1,213 participants aged 18 years and older at enrollment Diabetes Control Complications Trial (DCCT) were determined within randomized groups (INT vs....
Abstract Background Increasing diabetes prevalence affects a substantial number of pregnant women in the United States. Our aims were to evaluate health outcomes, medical costs, risks and types complications associated with pregnancy for mothers newborns. Methods In this retrospective claims analysis, patients identified from Truven Health MarketScan ® database (2004–2011 inclusive). Participants aged 18–45 years, ascertainable status [Yes/No], date birth event >2005 continuous plan...
OBJECTIVE: The objective was to assess relationships between beta-hydroxybutyrate (beta-OHB) level and pregnancy outcome in human light of the fact that high levels beta-OHB cause malformations growth retardation vitro studies. RESEARCH DESIGN AND METHODS: We analyzed prospectively collected specimens from National Institute Child Health Human Development-Diabetes Early Pregnancy Study, gestational weeks 6-12 diabetic (n = 204-239) nondiabetic 316-332) pregnant women. RESULTS: Levels women...
Once pregnancy is recognized clinically, it accepted that 12% to 15% undergo spontaneous abortion. However, the actual time of fetal demise has not yet been determined. To address this question, outcomes pregnancies identified before 21 days conception by serum beta-human chorionic gonadotropin assays were studied. All subjects underwent ultrasound examinations at eight and 12 weeks' gestation. Among 220 women who had a viable weeks, only seven (3.2%) experienced loss thereafter. The results...
OBJECTIVE—Early pregnancy losses increase with marked hyperglycemia in diabetic pregnancy. However, mean loss rates do not differ from those of nondiabetic This observation might be explained by increased fetal at the extremes glycemia and To test this hypothesis, we examined relationships proximate measures prior glycemia, glycated protein fructosamine, to loss. RESEARCH DESIGN AND METHODS—A total 389 429 pregnant subjects participated Diabetes In Early Pregnancy study. Glycated...
OBJECTIVE—To investigate whether pregnancies complicated by type 1 diabetes are associated with a decrease in first-trimester insulin requirement. RESEARCH DESIGN AND METHODS—We examined the weekly requirement (as units per kilogram day) during first trimester of pregnancy diabetic women Diabetes Early Pregnancy Study (DIEP) accurate gestational dating, regular glucose monitoring, daily insulin-dose recording, and monthly glycohemoglobin measurements. RESULTS—In that resulted live-born...
Because of the morbidity associated with undiagnosed gestational diabetes (GDM), screening programs are advocated in all pregnancy clinics. The purpose this study was to elucidate optimum time test for during gestation, indication retesting, and predictive value a positive large (>4000 g) infant. Women (N = 300) were screened at three points: 9–20 wk, 27–31 33–36 wk. An additional group 300 women two wk prevalence GDM 3.2%. timing highest yield Retesting appeared cost effective if (1)...
Background: The quest toward an artificial β-cell has been accelerating, propelled by recent technological advances in subcutaneous glucose sensors and insulin pumps. development clinical testing of algorithms involves several challenges: communication data transfer between a sensor pump via computer, human interface presenting real-time information to the physician, safety issues when automated system is used administer insulin, architecture that supports different sensors, pumps, control...