A5033155615- Eating Disorders and Behaviors
- Obsessive-Compulsive Spectrum Disorders
- Regulation of Appetite and Obesity
- Suicide and Self-Harm Studies
- Body Image and Dysmorphia Studies
- Child Nutrition and Feeding Issues
- Adipose Tissue and Metabolism
- Genetic Associations and Epidemiology
- Neurological disorders and treatments
- Obesity, Physical Activity, Diet
- Autism Spectrum Disorder Research
- Genetics and Neurodevelopmental Disorders
- Impact of Technology on Adolescents
- Biochemical Analysis and Sensing Techniques
- Diet and metabolism studies
- Transcranial Magnetic Stimulation Studies
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Electroconvulsive Therapy Studies
- Cancer, Lipids, and Metabolism
- Bipolar Disorder and Treatment
- Personality Disorders and Psychopathology
- Neurotransmitter Receptor Influence on Behavior
- Epigenetics and DNA Methylation
- Psychology of Moral and Emotional Judgment
- Mental Health Research Topics
Centre Hospitalier Sainte-Anne
2017-2025
Institut de Psychiatrie et Neurosciences de Paris
2018-2024
Université Paris Cité
2018-2024
Inserm
1995-2024
FHU Neurovasc
2019-2024
Sorbonne Paris Cité
2018-2024
GHU Paris psychiatrie & neurosciences
2021-2023
University of Utah
2023
Virginia Commonwealth University
2023
Huntsman (United States)
2023
Suicide is a leading cause of death worldwide, and nonfatal suicide attempts, which occur far more frequently, are major source disability social economic burden. Both have substantial genetic etiology, partially shared distinct from that related psychiatric disorders.
Extracellular acyl-coenzyme A binding protein [ACBP encoded by diazepam inhibitor (DBI)] is a phylogenetically ancient appetite stimulator that secreted in nonconventional, autophagy-dependent fashion. Here, we show low ACBP/DBI plasma concentrations are associated with poor prognosis patients anorexia nervosa, frequent and often intractable eating disorder. In mice, induced chronic restraint stress (CRS) accompanied reduction circulating concentrations. We engineered chemical-genetic system...
Dysregulation of habit formation has been recently proposed as pivotal to eating disorders. Here, we report that a subset patients suffering from restrictive anorexia nervosa have enhanced compared with healthy controls. Habit is modulated by striatal cholinergic interneurons. These interneurons express vesicular transporters for acetylcholine (VAChT) and glutamate (VGLUT3) use acetylcholine/glutamate cotransmission regulate functions. Using mice genetically silenced VAChT (VAChT conditional...
Background Affecting adolescent and young adults, anorexia nervosa (AN) has the highest death rate of all mental disorders. Effective treatment options are lacking a significant proportion patients develop severe chronic forms disease with long-lasting functional impairment. Neurobiology AN implicates nucleus accumbens as core structure ventral striatum highly connected to prefrontal cortex, insula limbic system. Several studies reported promising results deep brain stimulation for...
Eating disorders (ED) are associated with high rates of suicide attempts and premature mortality. However, data in large samples adolescents young adults limited. This study aims to assess the risk self-harm mortality people hospitalized an ED. Individuals aged 12 25 years old 2013-2014 France anorexia nervosa and/or bulimia as a primary or diagnosis were identified from French national health records. They compared two control groups no mental disorders, any other disorder than The main...
This study aims to investigate the impact of Mindfulness-Based Cognitive Therapy (MBCT) for bipolar disorders on emotional responses by using skin conductance recording, and a mediating or predictive effect cognitive reactivity.Sixty-seven patients with disorder were assessed at baseline, pre-MBCT post-MBCT. After answering inventories regarding depression dysfunctional attitudes, they instructed focus pictures from International Affective Pictures System while electrodermal recording.For...
Abstract Background Treatment of anorexia nervosa (AN) sometimes requires hospitalisation, which is often lengthy, with little ability to predict individual trajectory. Depicting specific profiles treatment response and their clinical predictors could be beneficial tailor inpatient management. The aim this research was identify clusters weight recovery during treatment, predictors. Methods A sample 181 inpatients who completed a programme for AN included in retrospective study. latent class...
Abstract Objective The study investigated interpersonal distance in patients with anorexia nervosa (AN), focussing on the role of other's facial expression and morphology, also assessing physiological subjective responses. Method Twenty‐nine AN 30 controls (CTL) were exposed to virtual characters either an angry, neutral, or happy overweight, normal‐weight, underweight morphology presented near far space while we recorded electrodermal activity. Participants had judge their preferred rated...
Abstract Cholinergic striatal interneurons (ChIs) express the vesicular glutamate transporter 3 (VGLUT3) which allows them to regulate network with and acetylcholine (ACh). In addition, VGLUT3-dependent increases ACh stores through synergy. A missense polymorphism, VGLUT3-p.T8I, was identified in patients substance use disorders (SUDs) eating (EDs). mouse line generated understand neurochemical behavioral impact of p.T8I variant. VGLUT3 T8I/T8I male mice, signaling unchanged but synergy...
Poor cognitive flexibility has been highlighted in patients with anorexia nervosa (AN), contributing to the development and maintenance of symptoms. The aim present study is investigate how enhanced involved treatment outcomes AN.One hundred thirty female out-patients treated for AN have assessed at baseline after 4 months treatment. Path analyses were used mediating role flexibility, measured through Brixton test, on a wide range outcomes: body mass index, eating disorder symptoms, daily...
Background Borderline personality disorder is often associated with self-injurious behaviors that cause personal suffering, family distress, and substantial medical costs. Mental health hotlines exist in many countries have been shown to be effective some contexts, but none specifically designed for borderline patients. The aim of the present study evaluate impact a 24/7 hotline dedicated patients on suicide attempts behaviors. Methods We conducted single-blind, multicenter (9 French...
Background Anorexia nervosa (AN) is a severe psychiatric disorder associated with frequent relapses and variability in treatment responses. Previous literature suggested that such influenced by premorbid vulnerabilities as abnormalities of the reward system. Several factors may indicate these vulnerabilities, neurocognitive markers (tendency to favour delayed reward, poor cognitive flexibility, abnormal decision process), genetic epigenetic markers, biological hormonal physiological markers....
Genetics and biology may influence the age of onset anorexia nervosa (AN). The aims this study were to determine whether common genetic variation contributes AN investigate associations between at menarche.
Abstract Background The persistence of physical exercise in anorexia nervosa (AN) despite underweight and its maintaining factors are poorly understood. aim this study was to explore the attitudes toward effects on emotions, cognitive functioning, body image perception patients with AN, search for exercise‐related endophenotypes pathology. Methods Physical dependence, quantity, dysregulation were assessed by Exercise Dependence Scale (EDS), Godin Leisure Time Questionnaire (GLTEQ) a...
Abstract Purpose Qualitative food avoidance is a significant issue in patients with anorexia nervosa (AN) and restoring diet diversity an important part of the treatment process. We aimed to identify clinical factors which drive predict its maintenance AN. Methods In this multicentre longitudinal study, 130 female outpatients AN were assessed before after 4 months care centres specialized levels 16 items, as well body mass index (BMI), eating disorder severity, symptoms depression anxiety,...
Highlights•Low LEAP-2 is a biomarker of undernutrition in physiological conditions•Patients with AN display higher levels undernourished compared to refed state•Abnormal regulation during refeeding associated unstable remissionSummaryLEAP-2 ghrelin antagonist an anorexigenic drive. This study investigates the evolution plasma and concentrations 29 patients anorexia nervosa (AN) before after compares it adaptations fasting healthy controls or mouse model chronic food restriction refeeding....