A5073384741- Radiomics and Machine Learning in Medical Imaging
- Bone Metabolism and Diseases
- MRI in cancer diagnosis
- Prostate Cancer Treatment and Research
- Renal cell carcinoma treatment
- Ferroptosis and cancer prognosis
- Nanoplatforms for cancer theranostics
- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
- Photodynamic Therapy Research Studies
- Breast Lesions and Carcinomas
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Extracellular vesicles in disease
- EEG and Brain-Computer Interfaces
- Intracerebral and Subarachnoid Hemorrhage Research
- Retinal Diseases and Treatments
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Paraquat toxicity studies and treatments
- Genetic factors in colorectal cancer
- Inflammatory mediators and NSAID effects
- Cerebral Venous Sinus Thrombosis
- Congenital Diaphragmatic Hernia Studies
- Phytochemical compounds biological activities
- Virus-based gene therapy research
- Folate and B Vitamins Research
Soochow University
2009-2024
Second Affiliated Hospital of Soochow University
2014-2024
Zhongda Hospital Southeast University
2022
Wuxi Ninth People's Hospital
2022
Zhangjiagang First People's Hospital
2009
Johns Hopkins University
2009
Nippon Life Hospital
2008
Quebec Labrador Foundation
2004
Chinese Academy of Medical Sciences & Peking Union Medical College
2000
Peking Union Medical College Hospital
2000
It is highly desirable to develop theranostic nanoparticles for achieving cancer imaging with enhanced contrast and simultaneously multimodal synergistic therapy.Herein, we report a micelle system hierarchically assembling cyanine dye (indocyanine green) chemotherapeutic compound (doxorubicin) (I/D-Micelles) as novel platform high drug loading, good stability cellular uptake via clathrin-mediated endocytosis.I/D-Micelles exhibit the multiple functionalities including near-infrared...
Abstract Background The 2019 novel coronavirus (COVID-19) presents a major threat to public health and has rapidly spread worldwide since the outbreak in Wuhan, Hubei Province, China 2019. To date, there have been few reports of varying degrees illness caused by COVID-19. Case presentation A case 68-year-old female with COVID-19 pneumonia who had constant pain right upper quadrant her abdomen during hospitalization that was finally diagnosed as acute cholecystitis. Ultrasound-guided...
Preoperative prediction of microsatellite instability (MSI) status in colorectal cancer (CRC) patients is great significance for clinicians to perform further treatment strategies and prognostic evaluation. Our aims were develop validate a non-invasive, cost-effective reproducible individualized clinic-radiomics nomogram method preoperative MSI based on contrast-enhanced CT (CECT)images.A total 76 CRC 200 stability (MSS) with pathologically confirmed (194 the training set 82 validation set)...
Multifunctional nanotheranostic agents are of particular importance in the field precise nanomedicine. However, a critical challenge remains rational fabrication monodisperse multicomponent nanoparticles with enhanced multifunctional characteristics for efficient cancer theranostics. Here, and facile synthesis Gd2 O3 /Bi2 S3 hybrid nanodots (Gd/Bi-NDs) is demonstrated as agent using albumin nanoreactor computed tomography (CT)/photoacoustics (PA)/magnetic resonance (MR) imaging simultaneous...
Background: The involvement of neutrophil-related genes (NRGs) in patients with osteosarcoma (OS) has not been adequately explored. In this study, we aimed to examine the association between NRGs and prognosis as well tumor microenvironment OS. Methods: OS data were obtained from TARGET-OS GEO database. Initially, extracted by intersecting 538 single-cell RNA sequencing (scRNA-seq) aneuploid diploid groups, 161 up-regulated differentially expressed (DEGs) datasets. Subsequently, conducted...
Many studies have demonstrated the small-worldness of human brain, and revealed a sexual dimorphism in brain network properties. However, little is known about gender effects on topological organization metabolic covariance networks.To investigate differences architectures networks.FDG-PET data 400 healthy right-handed subjects (200 women 200 age-matched men) were involved present study. Metabolic networks each constructed by calculating regional cerebral glucose metabolism (rCMglc) across...
Abstract Background Renal clear cell carcinoma (ccRCC) is one of the most common malignant tumors, whose incidence increasing year by year. IRF6 plays an important role in occurrence although there yet no report on its expression ccRCC. Methods The and KIF20A ccRCC was predicted GEPIA HAP databases. In addition, database relationship between expressions pathological staging, overall survival, disease-free survival possible binding sites promoters were JASPAR verified luciferase ChIP assays....
This study evaluated the diagnostic value of artificial intelligence-assistant system combined with contrast-enhanced ultrasound in The American College Radiology Thyroid Imaging, Reporting and Data System (ACR TI-RADS) 4 category thyroid nodules.Thyroid nodules that were as ACR TI-RADS by conventional selected, all which had pathological or fine needle aspiration (FNA) results. All examined (CEUS) intelligence (AI) analysis. sensitivity, specificity, accuracy, positive predictive (PPV)...
Objectives Intervertebral disc degeneration (IVDD) is a prevalent degenerative condition associated with high incidence rate of low back pain and disability. This study aimed to identify potential biomarkers signaling pathways IVDD.
Abstract Objectives Exploring the value of adding correlation analysis (radiomic features (RFs) pelvic metastatic lymph nodes and primary lesions) to screen RFs lesions in feature selection process establishing prediction model. Methods A total 394 prostate cancer (PCa) patients (263 training group, 74 internal validation group 57 external group) from two tertiary hospitals were included study. The cases with node metastasis (PLNM) positive diagnosed by biopsy or MRI a short-axis diameter ≥...
Abstract Background : Renal clear cell carcinoma (ccRCC) is one of the most common malignant tumors, and its incidence increasing year by year. IRF6 plays an important role in occurrence but expression ccRCC has not been reported so far. Methods: The KIF20A was predicted GEPIA HAP database. In addition, database relationship between pathological staging, overall survival, disease-free survival ccRCC. possible binding sites promoters were JASPAR verified luciferase ChIP experiments. specific...
Swine flu and avian outbreaks have occurred in recent years addition to seasonal flu. As mortality rate records are not available at the early stage of an outbreak, two parameters may be useful assess viral virulence : 1. time required for first domestic case a newly involved region, 2. doubling new infected cases. Viral is one most important factors guiding short term immediate responses. Although routine surveillance repeated vaccination efforts, some novel strategies that relevant prevent...
Objective To evaluate the value of digital radiography in relationship between ratio three lines and dislocation types developmental hip(DDH) infants. Methods One hundred forty six infants less than months old with suspected DDH were retrospectively reviewed. One (n=292 hips) included normal hips (n=36 cases), dysplasia (n=40 cases) (n=70 cases). Three measured from midpoint femoral metaphysis to upper margin, lower margin Y-shaped cartilage center acetabulum, respectively. The values...