Photoconversion tunability of fluorophore dye is great interest in cancer nanomedicine such as fluorescence imaging, photodynamic therapy (PDT), and photothermal (PTT). Herein, this paper reports wavelength-dependent photoconversional polymeric vesicles boron dipyrromethene (Bodipy) for either PDT under 660 nm irradiation or PTT 785 irradiation. After being assembled within at a high drug loading, Bodipy molecules aggregate the conformations both J-type H-type, thereby causing red-shifted...

Abstract High‐performance photosensitizers are highly desired for achieving selective tumor photoablation in the field of precise cancer therapy. However, frequently suffer from limited suppression or unavoidable regrowth due to presence residual cells surviving phototherapy. A major challenge still remains exploring an efficient approach promote dramatic photoconversions maximizing anticancer efficiency. Here, a rational design boron dipyrromethene (BDP)‐based conjugated (CPs) that can...

Bifunctional self-assembled nanoparticles with a platinated fluorophore core ultra-low radiative transition are developed, which can generate both singlet oxygen and the photothermal effect for synergistic photodynamic therapy tumor ablation.

Smart nanocarriers are of particular interest as nanoscale vehicles imaging and therapeutic agents in the field theranostics. Herein, we report dually pH/reduction-responsive terpolymeric vesicles with monodispersive size distribution, which constructed by assembling acetal- disulfide-functionalized star terpolymer near-infrared cyanine dye anticancer drug. The vesicular nanostructure exhibits multiple theranostic features including on-demand drug releases responding to pH/reduction stimuli,...

Stimuli‐responsive anticancer agents are of particular interest in the field cancer therapy. Nevertheless, so far stimuli‐responsive photothermal have been explored with limited success for therapy (PTT). In this work, as a proof‐of‐concept, pH‐responsive nanoconjugate enhanced PTT efficacy, which graphene oxide (GO) broad NIR absorbance and effective conversion efficiency is selected typical model receptor fluorescence resonance energy transfer (FRET), grafted cyanine dye (e.g., Cypate)...

It is highly desirable to develop theranostic nanoparticles for achieving cancer imaging with enhanced contrast and simultaneously multimodal synergistic therapy.Herein, we report a micelle system hierarchically assembling cyanine dye (indocyanine green) chemotherapeutic compound (doxorubicin) (I/D-Micelles) as novel platform high drug loading, good stability cellular uptake via clathrin-mediated endocytosis.I/D-Micelles exhibit the multiple functionalities including near-infrared...

Abstract Photothermal therapy (PTT) is of particular importance as a highly potent therapeutic modality in cancer therapy. However, critical challenge still remains the exploration effective strategy to maximize PTT efficiency due tumor thermoresistance and thus frequent recurrence. Here, rational fabrication micelles that can achieve mutual synergy molecularly targeted (MTT) for ablation reported. The generate both distinct photothermal effect from Cypate through enhanced conversion...

A series of unsymmetrical distyryl BODIPYs have been prepared which function as highly potent photosensitisers with in vitro IC(50) values low 15 nM. Their cellular uptake, subcellular localisation and photocytotoxicity depend greatly on the styryl substituents.

Abstract A zinc(II) phthalocyanine substituted with a 2,4‐dinitrobenzenesulfonate group has been prepared. Its fluorescence emission and reactive oxygen species generation can be greatly enhanced by glutathione in phosphate‐buffered saline inside MCF‐7 cells. This compound thus functions as highly efficient molecular‐based activatable photosensitizer.

Smart nanoparticles are increasingly important in a variety of applications such as cancer therapy. However, it is still major challenge to develop light‐responsive that can maximize the potency synergistic thermo‐chemotherapy under light irradiation. Here, spatially confined cyanine‐anchored silica nanochannels loaded with chemotherapeutic doxorubicin (CS‐DOX‐NCs) for light‐driven therapy introduced. CS‐DOX‐NCs possess J ‐type aggregation conformation cyanine dye within and encapsulate...

Abstract Triple‐negative breast cancer (TNBC) remains with highest incidence and mortality rates among females, a critical bottleneck lies in rationally establishing potent therapeutics against TNBC. Here, the self‐assembled micellar nanoarchitecture of heavy‐atom‐modulated supramolecules efficient cytoplasmic translocation tunable photoconversion is shown, for suppression primary, metastatic, recurrent Multi‐iodinated boron dipyrromethene micelles yield into singlet oxygen thermal effect,...

A series of pegylated distyryl boron dipyrromethenes have been prepared and characterized. Their in vitro photodynamic activities Tween 80 emulsions also investigated against HT29 human colorectal carcinoma cells. The derivative having five triethylene glycol chains (compound 8) exhibits the highest photocytotoxicity with an IC(50) as low 7 nM. It is localized preferentially endoplasmic reticulum cells can induce predominately apoptosis upon illumination.

Near-infrared (NIR) light-responsive nanoparticles of organic small-molecule dyes hold great promise as phototherapeutic (PDs) for clinical translation due to their intrinsic merits, including well-defined structure, high purity, and good reproducibility. However, they have been explored with limited success in the development photostable NIR PDs extraordinary photoconversion highly effective phototherapy. Herein, we described amphiphilic BODIPY dye aggregates within polymeric micelles...

Two monostyryl BODIPY derivatives that contain one or two bis(hydroxyamido)amino group(s) as the metal chelator have been prepared. The effects of various ions on their electronic absorption and fluorescence properties studied in detail MeCN phosphate buffered saline (PBS). results show derivative with hydroxyamide chains can selectively detect Zn(2+) MeCN. compound bind a 1:1 stoichiometry an association constant 2.2(±0.1)×10(4) M(-1). intensity emission increases remarkably is...

A novel distyryl boron dipyrromethene substituted with two 4-(dimethylamino)phenylethynyl groups at the 2- and 6-positions has been synthesised characterised. It exhibits remarkable reversible pH-responsive changes in absorption fluorescence emission spectra, both organic aqueous media.

Effective clinical practice of precise photodynamic therapy (PDT) is severely impeded by the inherent drawbacks and aggregation propensity conventional photosensitizers. An all-in-one approach highly desired to optimize structural features, photophysical properties, pharmacokinetic behaviors Herein, we have fabricated mesoporous boron dipyrromethene-bridged coordination polymer nanophotosensitizers (BCP-NPs) for high-performance PDT via a unique solvent-assisted assembly strategy....

Abstract Near‐infrared (NIR) light‐responsive nanoparticles (NPs) of organic photosensitizers (PS) hold great promise as phototherapeutic agents for precision photoinduced cancer therapy. However, highly photostable PS with extraordinary photoconversion capacities are urgently desired to fully realize potent phototherapy. Here, NIR nonlinear chromophore (NOC‐NPs) shown single‐component dually cooperative Upon 785 nm irradiation, excited NOC‐NPs pass through intrinsic intramolecular charge...

Biotinidase (BTD) deficiency (OMIM 253260) is an autosomal recessively inherited metabolic disorder resulting from deficient activity of the BTD enzyme, which can cleave and release biotin a variety biotin-dependent carboxylases, therefore recognized as tool to recycle biotin. Being condition caused by variations on gene with consequence free shortage, may impair thus bring about buildup potentially toxic compounds in body, primarily 3-hydroxyisovaleryl-carnitine plasma well...

This paper describes the preparation and spectral properties of a near-infrared fluorophore in which two bis(2-picolyl)amino moieties are axially linked to silicon(IV) phthalocyanine core. The effects various metal ions on its absorption fluorescence spectra have been examined. results indicate that this compound shows high sensitivity moderate selectivity toward Zn 2+ ion.

BackgroundGiven the differential expression and biological functions of protein arginine methylation (PAM) regulators in lung adenocarcinoma (LUAD), it may be great value diagnosis, prognosis, treatment LUAD. However, function PAM LUAD its relationship with prognosis are unclear.Methods8 datasets including 1798 patients were selected. During bioinformatic study LUAD, we performed (i) consensus clustering to identify clusters based on 9 related profile data, (ii) hub genes between 2 clusters,...

Glycolysis is closely associated with cancer progression and treatment outcomes. However, the role of glycolysis in immune microenvironment, prognosis, immunotherapy glioma remains unclear.This study investigated on prognosis its relationship tumor microenvironment (TME). Subsequently, we developed validated glycolysis-related gene signature (GRS)-TME classifier using multiple independent cohorts. Furthermore, also examined prognostic value, somatic alterations, molecular characteristics,...

Self-assembled nanoparticles of platinated Bodipy, described by H. B. Chen on page 10155, produce both singlet-to-triplet and nonradiative transitions through the heavy-atom effect a d–d energy-band transition platinum under light irradiation, accompanied an ultralow radiative transition. These allow to generate singlet oxygen photothermal for synergistic photodynamic treatments with tumor ablation.