Abstract Background Patients with end-stage renal disease (ESRD) are at a higher risk for chronic hepatitis, liver cirrhosis (LC) and mortality than the general population. Optimal modalities of replacement therapy ESRD patients concomitant remain controversial. We investigated long-term outcome among dialysis in an endemic area. Methods Using Taiwan’s National Health Insurance claim data (NHRI-NHIRD-99182), performed longitudinal cohort study to investigate impact comorbidities on patients....

Both hypokalemia (hypoK) and hyperkalemia (hyperK) are life-threatening to hemodialysis (HD) patients. This study was conducted compare their clinical characteristics long-term survival.Patients were divided into three groups according the last mid-week predialysis serum potassium concentrations: hypoK (<3.5 mEq/l), normoK (between 3.5 5.5 hyperK (>5.5 mEq/l). The maximal duration of follow-up period 54 months.Compared with group,patients in group older (p <0.05), had a higher incidence...

Diabetes mellitus is the most common chronic disease in world, and a wide range of drugs, including Chinese herbs, have been evaluated for treatment associated metabolic disorders. This study investigated potential hypoglycemic renoprotective effects an extract from solid-state fermented mycelium Cordyceps sinensis (CS). We employed KK/HIJ diabetic mouse model, which mice were provided with high-fat diet 8 weeks to induce hyperglycemia, followed by administration CS or rosiglitazone 4...

A high sensitivity C-reactive protein to albumin ratio (hs-CRP/Alb) predicts mortality risk in patients with acute kidney injury. However, it varies dynamically. This study was conducted evaluate whether a variation of this marker associated long-term outcome clinically stable hemodialysis (HD) patients.hs-CRP/Alb checked bimonthly 284 HD outpatients throughout all 2008. Based on the "slope" trend equation derived from 5-6 hs-CRP/alb ratios for each patient, total number divided into...

Both diabetes mellitus (DM) and hepatitis C virus infection (HCVI) are associated with chronic kidney disease (CKD). The aim of this study was to evaluate whether HCVI increases the risk end-stage renal (ESRD) in patients DM. National Health Insurance Research database Taiwan used conduct study. After excluding a prior history CKD, all first diagnosis DM from January 1, 2000 December 31, 2002 were enrolled. who also had defined as index cases (HCV group, n = 9787). A comparison cohort at 1:1...

HYPERTENSION IntroductIonHypertension (HTN) is an important public health problem and affects 24% of the general population. 1 The prevalence HTN in patients with chronic kidney disease (CKD) significantly exceeds that seen population; it estimated to be more than 70% end-stage renal (ESRD) undergoing hemodialysis (HD). 2,3 Patients CKD are highest risk group for cardiovascular events. 4Although predictor mortality, several studies 1,5,6 have questioned link between mortality HD...

Abstract Background The aim of this study was to evaluate whether a high baseline level high-sensitivity C-reactive protein (hs-CRP) or changes in the predicts risk peritonitis patients on continuous ambulatory peritoneal dialysis (CAPD). Methods A prospective, cross-sectional, case–control conducted single hospital-based PD unit. total 327 were included study. Serum hs-CRP measured annually for 2 years. Patients divided into 4 groups according annual levels (at and at 1 year intervals):...

The role of specific pathological findings in the upper gastrointestinal tract chronic renal failure remains uncertain. Most studies were conducted West, and number subjects was small. We have tried to look at that problem Taiwan. Endoscopy evaluate source hemorrhage performed 698 patients over a 37-month period; represents 4.4% all undergoing endoscopy for miscellaneous reasons time span. Fifty-eight (8.3%) who had been hemodialyzed selected, as 640 control did not failure. Patients with...

Systemic lupus erythematosus (SLE) patients are associated with insulin resistance and at higher risk to develop diabetes mellitus (DM). SLE DM could lead renal failure respectively. However, it is unknown whether increases the of end-stage disease (ESRD) in patients. This study aimed evaluate potential synergistic effect on for development ESRD. We conducted this by using National Health Insurance Research Database Taiwan. recruited newly-diagnosed as cohort. A comparison cohort a 1:1 ratio...

ABSTRACT PCR coupled with electrospray ionization mass spectrometry (PCR/ESI-MS) was compared culture for pathogen detection in peritoneal dialysis (PD)-related peritonitis. Of 21 samples of PD effluent, PCR/ESI-MS identified microorganisms 18 (86%) samples, including Mycobacterium tuberculosis 1 culture-negative sample. 15 double-positive and reached levels agreement 100% (15/15) 87.5% (7/8) at the genus species levels, respectively. can be used rapid PD-related

Background Residual renal function (RRF) is pivotal to long-term outcomes, while rapid RRF decline (RRFD) associated with mortality risk for continuous ambulatory peritoneal dialysis (CAPD) patients. This study was conducted compare the impact of “initial anuria” and RRFD on prognosis CAPD Method According timing anuria slope RRFD, a total 255 incident patients were divided into 3 groups. For “anuria” group, detected from initiation persisted &gt; 6 months ( n = 27). Based median slope,...

The prevalence of cardiovascular (CV) disease in patients undergoing maintenance hemodialysis (HD) is reportedly higher than that healthy individuals. In the present study, we aimed to investigate whether ultrasonographically documented fatty liver (FLD) an independent risk factor for nonfatal CV events HD.A retrospective cohort study was conducted a medical center southern Taiwan. records 490 HD who were enrolled between July 1998 and October 2012 screened. Finally, 278 had undergone...

To assess the effect of seasonal temperature on interdialytic body weight gain (deltaBW), %deltaBW/dry (DW), and pre-dialysis blood pressure in chronic hemodialysis (HD) patients with different degrees overhydration.Year 2005 was divided into two seasons: 'cold' (the coolest 5 months) 'hot' hottest months). A total 221 end-stage renal disease treated HD at our center throughout year were enrolled.DeltaBW showed a reversed trend to water evaporation rate, which paralleled change. Increases...

The purpose of this study was to evaluate the combined effect different pre-hemodialysis (HD) serum sodium (S[Na]) and potassium (S[K]) concentrations on long-term prognosis HD patients.A cohort 424 maintenance patients (age: 58 ± 13 years, male: 47%, diabetes: 39%) from a single center were divided into four groups based both medians S[Na] (138.4 mmol/L) S[K] (4.4 mmol/L): Group 1: lower & S[K]: n = 92; 2: higher =113; 3: =123; 4: =96. median observation period 21 months.By multivariate...

Serum prealbumin level is slightly higher, whereas albumin lower in peritoneal dialysis (PD) than hemodialysis (HD) patients. It unknown whether to ratio (APR) associated with mortality risk among PD This study aimed evaluate the clinical implications of APR and its prediction value on long-term outcomes patients.The population were prevalent patients at a tertiary hospital. Based APR, total 220 divided into 3 groups: group 1: top tertile, median APR: 121.1; IQR:109.5-131.9 (n = 73, male:...

Cyclin D1 plays significant roles in cell cycle entry and migration. We have documented that both integrin α3β1 expressions the number of podocytes were reduced focal segmental glomerulosclerosis. wondered whether integrin-extracellular matrix (ECM) interaction was involved regulation cyclin expression, possible signaling pathways mitogen-stimulating podocytes. Cultured divided into serum (mitogens/growth factors)-starved serum-stimulated groups. Reverse transcription polymerase chain...

High urologic malignancy incidence has been reported in end-stage renal disease (ESRD) patients, especially of female sex. This study was undertaken to evaluate whether recipients still carry an aggravated risk this after kidney transplantation (KT).The claims data from the Bureau National Health Insurance Taiwan were used for analysis. All KT who developed January 1, 1999, December 31, 2007 (n = 2,245) enrolled study. By means propensity score, a database 1:4 ratio random incident ESRD...

The appropriate dialysate calcium concentration (D[Ca]) for hemodialysis (HD) therapy has not yet reached a consensus. We have conducted prospective control study five years on the effects of different D[Ca] serum intact parathyroid hormone (iPTH) levels. Patients were divided into three groups receiving therapies: low-Ca (D[Ca] = 2.5 mEq/L; N 96), mid-Ca 3.0 121), and high-Ca 3.5 82) groups. After years' study, only 41 patients in group, 34 32 group completed study. results demonstrated...