A5038047583- Nanoparticle-Based Drug Delivery
- Plant Virus Research Studies
- RNA Interference and Gene Delivery
- Advanced Materials and Mechanics
- Advanced biosensing and bioanalysis techniques
- Neurological disorders and treatments
- Plant tissue culture and regeneration
- Insect-Plant Interactions and Control
- Plant and Fungal Interactions Research
- Neuroscience and Neural Engineering
- Nanoplatforms for cancer theranostics
- Bacteriophages and microbial interactions
- Insect Resistance and Genetics
- Sex and Gender in Healthcare
- Parkinson's Disease Mechanisms and Treatments
- Cancer Research and Treatments
- Micro and Nano Robotics
- Electrohydrodynamics and Fluid Dynamics
Technion – Israel Institute of Technology
2021-2024
Abstract Monoclonal antibodies (mAbs) hold promise in treating Parkinson's disease (PD), although poor delivery to the brain hinders their therapeutic application. In current study, it is demonstrated that brain‐targeted liposomes (BTL) enhance of mAbs across blood‐brain‐barrier (BBB) and into neurons, thereby allowing intracellular extracellular treatment PD brain. BTL are decorated with transferrin improve targeting through overexpressed transferrin‐receptors on BBB during PD. loaded...
Abstract Inorganic therapeutic carriers and implants should not only be biocompatible, but also degrade under physiological conditions. Ideally, the time of degradation can controlled, ideally products are fully biocompatible metabolized by body. This proves a challenge for used in nanomedicine, including microswimmers nanorobotic systems destined targeted delivery, as these generally require inorganic materials to enable coupling external fields. Taking inspiration from macroscopic...
Males and females respond differently to medications due physiologic, metabolic, genetic factors. At times, sex‐related differences cannot be mitigated by dose adjustment body mass, are evident from the tissue level single cell. The rising number of clinically approved nanotechnologies calls for assessing how their activity is affected patient's sex. Herein, sex in nanotechnology scoped, with emphasis on molecular considerations. Sex‐specific pharmacokinetics nanocarriers influenced...
Abstract Grapevine leafroll disease (GLD) is a globally spreading viral infection that causes major economic losses by reducing crop yield, plant longevity, and berry quality, with no effective treatment. associated virus‐3 (GLRaV‐3) the most severe, prevalent GLD strain affecting wine production. Here, ability of RNA interference (RNAi), non‐GMO gene‐silencing pathway, to treat GLRaV‐3 in infected Cabernet Sauvignon grapevines evaluated. Lipid‐modified polyethylenimine (lmPEI) synthesized...
Brain-Targeted Liposomes In article number 2304654, Avi Schroeder and co-workers describe a targeted nanotechnology drug delivery system for treating Parkinson's disease. Brain-targeted liposomes—nanoparticles engineered with transferrin on their surface carry therapeutic antibodies, cross the blood–brain barrier effectively treat brain neurodegeneration. This approach reduces pathological alpha-synuclein aggregation improves motor skills, demonstrating its potential neurodegenerative diseases.
Isoamylase (ISA) is a debranching enzyme found in many plants, which hydrolyzes (1-6)-α-D glucosidic linkages starch, amylopectin, and β-dextrins, thought to be responsible for starch granule formation (ISA1 ISA2) degradation (ISA3). Lipid-modified PEI (lmPEI) was synthesized as carrier long double-stranded RNA (dsRNA, 250-bp), targets the three isoamylase isoforms. The particles were applied plant via foliar spray differentially effective suppressing expressions of ISA1 ISA2 potato leaves,...